Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tetraspanin-2

Gene

Tspan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.By similarity

GO - Biological processi

  • astrocyte development Source: MGI
  • axon development Source: MGI
  • brain development Source: Ensembl
  • cell surface receptor signaling pathway Source: GO_Central
  • inflammatory response Source: MGI
  • microglia development Source: MGI
  • myelination Source: MGI
  • oligodendrocyte differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-2
Short name:
Tspan-2
Gene namesi
Name:Tspan2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917997 Tspan2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 54ExtracellularSequence analysisAdd BLAST20
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 90CytoplasmicSequence analysisAdd BLAST15
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 188ExtracellularSequence analysisAdd BLAST77
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 221CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192371 – 221Tetraspanin-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ922J6
PaxDbiQ922J6
PRIDEiQ922J6

PTM databases

iPTMnetiQ922J6
PhosphoSitePlusiQ922J6
SwissPalmiQ922J6

Expressioni

Gene expression databases

BgeeiENSMUSG00000027858 Expressed in 246 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_TSPAN2
ExpressionAtlasiQ922J6 baseline and differential
GenevisibleiQ922J6 MM

Interactioni

Protein-protein interaction databases

BioGridi214232, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ922J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ922J6
KOiK17354
OMAiQSTCPKE
OrthoDBiEOG091G0K9H
PhylomeDBiQ922J6
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q922J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG TMKDLSSEDK
60 70 80 90 100
SPEYFYVGLY VLVGAGALMM TVGFFGCCGA MRESQCVLGS FFTCLLVIFA
110 120 130 140 150
AEVTTGVFAF IGKDVAIRHV QSMYEEAYSD YLKDRARGNG TLITFHSAFQ
160 170 180 190 200
CCGKESSEQV QPTCPKELPG HKNCIDKIET VISAKLQLIG IVGIGIAGLT
210 220
IFGMIFSMVL CCAIRNSRDV I
Length:221
Mass (Da):24,181
Last modified:December 1, 2001 - v1
Checksum:i9DF8BE399DD3EE5A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEZ7A0A0G2JEZ7_MOUSE
Tetraspanin
Tspan2
153Annotation score:
Q9D1X8Q9D1X8_MOUSE
Tetraspanin
Tspan2 mCG_6403
217Annotation score:
A0A0G2JDX4A0A0G2JDX4_MOUSE
Tetraspanin-2
Tspan2
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → M in BAB31109 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018178 mRNA Translation: BAB31109.1
AK032520 mRNA Translation: BAC27907.1
AK049888 mRNA Translation: BAC33972.1
AK079560 mRNA Translation: BAC37684.1
BC007185 mRNA Translation: AAH07185.1
CCDSiCCDS17688.1
RefSeqiNP_081809.2, NM_027533.3
UniGeneiMm.27469

Genome annotation databases

EnsembliENSMUST00000029451; ENSMUSP00000029451; ENSMUSG00000027858
GeneIDi70747
KEGGimmu:70747
UCSCiuc008qrw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018178 mRNA Translation: BAB31109.1
AK032520 mRNA Translation: BAC27907.1
AK049888 mRNA Translation: BAC33972.1
AK079560 mRNA Translation: BAC37684.1
BC007185 mRNA Translation: AAH07185.1
CCDSiCCDS17688.1
RefSeqiNP_081809.2, NM_027533.3
UniGeneiMm.27469

3D structure databases

ProteinModelPortaliQ922J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214232, 1 interactor

PTM databases

iPTMnetiQ922J6
PhosphoSitePlusiQ922J6
SwissPalmiQ922J6

Proteomic databases

MaxQBiQ922J6
PaxDbiQ922J6
PRIDEiQ922J6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029451; ENSMUSP00000029451; ENSMUSG00000027858
GeneIDi70747
KEGGimmu:70747
UCSCiuc008qrw.2 mouse

Organism-specific databases

CTDi10100
MGIiMGI:1917997 Tspan2

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ922J6
KOiK17354
OMAiQSTCPKE
OrthoDBiEOG091G0K9H
PhylomeDBiQ922J6
TreeFamiTF352895

Miscellaneous databases

ChiTaRSiTspan2 mouse
PROiPR:Q922J6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027858 Expressed in 246 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_TSPAN2
ExpressionAtlasiQ922J6 baseline and differential
GenevisibleiQ922J6 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN2_MOUSE
AccessioniPrimary (citable) accession number: Q922J6
Secondary accession number(s): Q543K4, Q9D397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again