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Protein

Solute carrier family 25 member 36

Gene

Slc25a36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 36
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924909 Slc25a36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei41 – 57Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei111 – 131Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 200Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei291 – 311Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917981 – 311Solute carrier family 25 member 36Add BLAST311

Proteomic databases

MaxQBiQ922G0
PaxDbiQ922G0
PeptideAtlasiQ922G0
PRIDEiQ922G0

PTM databases

iPTMnetiQ922G0
PhosphoSitePlusiQ922G0
SwissPalmiQ922G0

Expressioni

Gene expression databases

BgeeiENSMUSG00000032449
CleanExiMM_SLC25A36
ExpressionAtlasiQ922G0 baseline and differential
GenevisibleiQ922G0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082302

Structurei

3D structure databases

ProteinModelPortaliQ922G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 108Solcar 1Add BLAST105
Repeati116 – 203Solcar 2Add BLAST88
Repeati224 – 308Solcar 3Add BLAST85

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0757 Eukaryota
ENOG410XS20 LUCA
GeneTreeiENSGT00550000074670
HOGENOMiHOG000188210
HOVERGENiHBG059891
InParanoidiQ922G0
KOiK15116
OMAiESTLQWV
OrthoDBiEOG091G0BCW
PhylomeDBiQ922G0
TreeFamiTF314220

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q922G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRDTLVHL FAGGCGGTVG AILTCPLEVV KTRLQSSSVT LYISEVQLNT
60 70 80 90 100
MAGASVNRVV SPGPLHCLKA ILEKEGPRSL FRGLGPNLVG VAPSRAIYFA
110 120 130 140 150
AYSNCKEKLN GVFDPDSTQV HMASAAMAGF TAITATNPIW LIKTRLQLDA
160 170 180 190 200
RTRGEKQMGA FECVRKVYQT DGLRGFYRGM SASYAGISET VIHFVIYESI
210 220 230 240 250
KQKLLECKTA SMMETDEESV KEASDFVRMM LAAATSKTCA TTIAYPHEVV
260 270 280 290 300
RTRLREEGTK YRSFFQTLSL IVQEEGYGSL YRGLTTHLVR QIPNTAIMMA
310
TYELVVYLLN G
Length:311
Mass (Da):34,170
Last modified:December 1, 2001 - v1
Checksum:i955FFBD45BA78F48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042075 mRNA Translation: BAE20619.1
AK053646 mRNA Translation: BAC35461.1
AK078779 mRNA Translation: BAC37391.1
BC008171 mRNA Translation: AAH08171.1
CCDSiCCDS23420.1
RefSeqiNP_620095.1, NM_138756.4
UniGeneiMm.228067
Mm.475433

Genome annotation databases

EnsembliENSMUST00000085206; ENSMUSP00000082302; ENSMUSG00000032449
GeneIDi192287
KEGGimmu:192287
UCSCiuc009rdb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS2536_MOUSE
AccessioniPrimary (citable) accession number: Q922G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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