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Protein

Probable glucose transporter rco-3

Gene

rco-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable glucose transporter. Involved in sugar transport, carbon catabolite repression, and initiation of conidiophore development.

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • glucose transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose transporter rco-3
Gene namesi
Name:rco-3
ORF Names:B5K2.040, NCU02582
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02582

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 73ExtracellularSequence analysisAdd BLAST39
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 103CytoplasmicSequence analysis9
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125ExtracellularSequence analysis1
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 159CytoplasmicSequence analysisAdd BLAST13
Transmembranei160 – 180Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini181 – 193ExtracellularSequence analysisAdd BLAST13
Transmembranei194 – 214Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini215 – 293CytoplasmicSequence analysisAdd BLAST79
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 318ExtracellularSequence analysis4
Transmembranei319 – 339Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini340 – 345CytoplasmicSequence analysis6
Transmembranei346 – 366Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini367 – 378ExtracellularSequence analysisAdd BLAST12
Transmembranei379 – 403Helical; Name=10Sequence analysisAdd BLAST25
Topological domaini404 – 415CytoplasmicSequence analysisAdd BLAST12
Transmembranei416 – 436Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini437 – 454ExtracellularSequence analysisAdd BLAST18
Transmembranei455 – 475Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini476 – 594CytoplasmicSequence analysisAdd BLAST119

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504211 – 594Probable glucose transporter rco-3Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ92253

Structurei

3D structure databases

ProteinModelPortaliQ92253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870
InParanoidiQ92253
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIFAMGWQK PDNVAGSSAP AIMVGLFVAT GGLLLGYDTG TINGILAMKS
60 70 80 90 100
FKDHFSTGYI DGNGQPGIYP KESALIVAML SAGTAIGALL AAPLGDHYGR
110 120 130 140 150
RRSLIGAIGI FVIGAILQVC AYNIDLLVAG RTVAGVGIGI VSVLVPLYQS
160 170 180 190 200
EMAPKWIRGT LVCTYQLSIT MGLLAAAVVN ILTYKLKTAA AYRVPIGLQL
210 220 230 240 250
TWACVLALGL TVLPETPRYL IKRGDKNAAA LSLSRLRRLD ITHPALVEEL
260 270 280 290 300
AEIEANHQYE MALGPDSYKD ILFGEPHLGR RTFTGCCLQM LQQLTGVNFI
310 320 330 340 350
MYYGTTFFNN AGVGNPFKIS LIMQVINTAS TIPGLFVVES WGRRRLLMVG
360 370 380 390 400
AIGMAICQLL IAAFATASGS NNLSAQNKVL ITFVAIYIFF FAASWGPVVW
410 420 430 440 450
VVTSEIYPLK VRAKSMSITT ASNWFLNFGI AYGTPYMQTN SAASDESSID
460 470 480 490 500
LGSKVFFVWG AFCIVAVGFV WCMVYETSKI SLEQIDEMYE RVDHAWHSRR
510 520 530 540 550
FEPSWSFQEM RDLGFSDGGI PPTQQLQQQP QQPQQQQQQH HQQQQHQLQV
560 570 580 590
DLQQSQSRTS NSSTSQTDTG GSNNTGASQD DKLVASLGNI DLSY
Length:594
Mass (Da):64,626
Last modified:June 7, 2005 - v2
Checksum:i7169AF184A5E9FE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317F → L in AAA99806 (PubMed:9178001).Curated1
Sequence conflicti376Q → H in AAA99806 (PubMed:9178001).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54768 Genomic DNA Translation: AAA99806.1
BX842632 Genomic DNA Translation: CAE76420.1
CM002236 Genomic DNA Translation: EAA36477.1
RefSeqiXP_965713.1, XM_960620.2

Genome annotation databases

EnsemblFungiiEAA36477; EAA36477; NCU02582
GeneIDi3881863
KEGGincr:NCU02582

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U54768 Genomic DNA Translation: AAA99806.1
BX842632 Genomic DNA Translation: CAE76420.1
CM002236 Genomic DNA Translation: EAA36477.1
RefSeqiXP_965713.1, XM_960620.2

3D structure databases

ProteinModelPortaliQ92253
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92253

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA36477; EAA36477; NCU02582
GeneIDi3881863
KEGGincr:NCU02582

Organism-specific databases

EuPathDBiFungiDB:NCU02582

Phylogenomic databases

HOGENOMiHOG000202870
InParanoidiQ92253
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRCO3_NEUCR
AccessioniPrimary (citable) accession number: Q92253
Secondary accession number(s): Q7RVM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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