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Protein

Putative fatty acid synthase subunit TOXC

Gene

TOXC

Organism
Cochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential role in the production of HC-toxin and in pathogenicity of the fungus on maize. May contribute to the synthesis of the decanoic backbone of 2-amino-9,10-epoxi-8-oxodecanoic acid. This protein contains domains similar to those of a fatty acid synthase beta subunit, namely: [acyl-carrier protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: HC-toxin biosynthesis

This protein is involved in the pathway HC-toxin biosynthesis, which is part of Mycotoxin biosynthesis.
View all proteins of this organism that are known to be involved in the pathway HC-toxin biosynthesis and in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei276For acetyltransferase activityBy similarity1
Active sitei1828For malonyltransferase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNAD, NADP

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00874

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative fatty acid synthase subunit TOXC
Including the following 5 domains:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC:4.2.1.59)
Enoyl-[acyl-carrier-protein] reductase [NADH] (EC:1.3.1.9)
[Acyl-carrier-protein] acetyltransferase (EC:2.3.1.38)
[Acyl-carrier-protein] malonyltransferase (EC:2.3.1.39)
S-acyl fatty acid synthase thioesterase (EC:3.1.2.14)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOXC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCochliobolus carbonum (Maize leaf spot fungus) (Bipolaris zeicola)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5017 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001802911 – 2080Putative fatty acid synthase subunit TOXCAdd BLAST2080

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q92215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q92215

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92215

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1538 – 1667MaoC-likeAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 468AcetyltransferaseBy similarityAdd BLAST468
Regioni481 – 869Enoyl reductaseBy similarityAdd BLAST389
Regioni1155 – 1644DehydrataseBy similarityAdd BLAST490
Regioni1645 – 1865Malonyl/palmitoyl transferaseBy similarityAdd BLAST221

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.40.366.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013785 Aldolase_TIM
IPR013565 DUF1729
IPR003965 Fatty_acid_synthase
IPR016452 Fatty_acid_Synthase_bsu_fun
IPR029069 HotDog_dom_sf
IPR039569 MaoC-like_dehydrat_N
IPR002539 MaoC-like_dom
IPR020801 PKS_acyl_transferase
IPR032088 SAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08354 DUF1729, 1 hit
PF13452 MaoC_dehydrat_N, 1 hit
PF01575 MaoC_dehydratas, 1 hit
PF16073 SAT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005562 FAS_yeast_beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01483 FASYNTHASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52151 SSF52151, 2 hits
SSF54637 SSF54637, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLTAQIPES LTPFSISHGS LSVSWLLPYR LHCYATRLYR TFEATLAARS
60 70 80 90 100
DNSEHPITLL SSVELAAHYM CYVAHETQAN TDRACTQTHD ISKLLLEDFE
110 120 130 140 150
ATFLRSNDIH TLASALPSSD SAKDELLRCY YETCFITKHN TPLNESALLK
160 170 180 190 200
AAREGIVSLY TTFSGQGCGG RYFDELRELF RLYPSFVGTL ISESGNLFRE
210 220 230 240 250
LASNPSAGRL FSKGFDIMAW LHHPQTTPDT EYLISAPVSF PIIGLVQLGH
260 270 280 290 300
YAVSCRAMGL DPGAFQRSIR GSTGHSQGIV VAAAMSAADS WEAFDRLAIS
310 320 330 340 350
CLTVLFWIGV RSQQAAPQMS LSPAQIQDSI DHNEDVPSPM LSIIGLSRLD
360 370 380 390 400
VQMHIDSINH YLPQSEHISI SLVNGGRHIV VSGLPSTLYR FNLLLRKIKV
410 420 430 440 450
PDHSGQPRAT SKQKKAQFSA RFLPITVPFH SHHLVSVGSV LEEDLKNVFI
460 470 480 490 500
GSKDLGFPVF NTYTGRDLRA EVIGNIVPAL VRMVTQYPVF WGAAVEFPGA
510 520 530 540 550
THILEFGPGG LSGSGALTSH IKNGTGVRVI FAGLTSGSNR QVGYKQELFA
560 570 580 590 600
RDTCHVKFAD DWSRKYAPSL VRTSNNSIVV NTKMSRLLGL PPIMVGGMTP
610 620 630 640 650
TTAAWGFVAA TMNAGYHIEL AAGGYSDANA FENALLNIQK TTASGRGITV
660 670 680 690 700
NLIYLSSHAV NWQIPLLRRL IIDGFRIEGI TIGGGVPSID VAKEYITTLG
710 720 730 740 750
IKHIGFKPGP TTAIDAVIEI AQANPTFPVF LQWTGGRSGG HHSNEDFHQP
760 770 780 790 800
ILETYDRIRQ CDNIILIAGS GFGGAADTYP YITGEWSLRY DFPPMPFDGC
810 820 830 840 850
LLGSRVMVAK EARTSPAAKR VIVETEGLND NEWRRTYEEA AGGIITVQSE
860 870 880 890 900
MGQPIHKIAT RGVLFWAKLD QMIFSLPKEK RIAELQKHRS WIIKGLNDDF
910 920 930 940 950
QKPWFGRDSA DQVVELRDMT YAEVLRRMVQ LLYVKHQRRW IHSSYAVLFK
960 970 980 990 1000
AFVNRLEERF TTKTVQSYLI QDCKTIDDPY NIITVVLLQY QQAIKETILT
1010 1020 1030 1040 1050
PDVEYFLLLC KRRGQKPVPF VPALDEDFEF FFKKDSLWQS EDLEAVVDQD
1060 1070 1080 1090 1100
VGRTCILQGP VAAKYSVKVD EPIAEILGSI HQGHVTRLRE ERYCATLDSI
1110 1120 1130 1140 1150
PFVEYFGGES IQLDMSSLAD GIEQSHNEQA SIYSLPSSLS MPLPAVDVWM
1160 1170 1180 1190 1200
SLLAGKSRSW RHAIMSAGIV IQENKCVANP MRRLFAPAHG IRVQIRKPDV
1210 1220 1230 1240 1250
PSQTEVVLEE QQESGIYEVA VRAGLNEDGE IIVEMFERRN MSDLVVSLPC
1260 1270 1280 1290 1300
DSGTKPEYGY APIREIMEDR NERIRRFYWS IWFGKSHPIL EGSLSDSFEC
1310 1320 1330 1340 1350
GKEKITRQHV ESFIQAINNS TRTHKNFLEP ATNVSISFAI PVAWKAIVKP
1360 1370 1380 1390 1400
LFLNALNGDL LQLVHLSNEF RMTPGAEPLK IGEEVSTVAR INAIMNQDSG
1410 1420 1430 1440 1450
KMVEVSAAVL RGKEIVVEII SRFLYRGAFV DFKDTFQWRD EPLMQIQLAT
1460 1470 1480 1490 1500
SKHIAVLRTR EWFVPTQGCN IDLVGHTLTF QMRSLYKFQS KTVFRRIETH
1510 1520 1530 1540 1550
GKVTLELAPQ KIVQVATVQY EVGICHSNTV IEFLDRYGSY SQNSVDFEDP
1560 1570 1580 1590 1600
VSVPNNGESL VICAPSSNEA YARTSGDLNP IHVSRTFAEY AGLPGLITHG
1610 1620 1630 1640 1650
MYCSAAIQDL VERLVADGNA GRIRQFSMSF VGMVLPNQKL EVKLEHIGMV
1660 1670 1680 1690 1700
EGMIRLHIEA RAQETGHRVI VGEAKITQKM TTYVFTGQGS QEKGMGMDLY
1710 1720 1730 1740 1750
NQCPAAREVW DRGDKYFLHK YGFAITTIVR DNPKQLTVHF GGRQGEAIRQ
1760 1770 1780 1790 1800
NYINMKVETV AEDGSIQYEK LFKDVDHNTQ FYTFRSPTGL LSATQFTQPA
1810 1820 1830 1840 1850
LSLMARASFE HLQIQGLVDG NCYYAGHSLG EFSALAAVAG IMSVESQALI
1860 1870 1880 1890 1900
AFYRGLTMQK AVNRDESGRS NYSMCAVDPS RISATYDEEA FLTIVREIAA
1910 1920 1930 1940 1950
ETGWLLEVVN FNVANKQYVC AGNLHALDTL AGVTDRLRLL QINASEMEEC
1960 1970 1980 1990 2000
LHEIIRQCVQ ETKSKSTPLE LTRGIATIPL QGIDVPFHST FLRGGVRHFR
2010 2020 2030 2040 2050
EFLHENIDKR NINPAKLIGR YIPNVTARSF QISKDYFQYV YDLTGSSQLR
2060 2070 2080
DALKNWDIYE KSNGEESNGV EECSECRNSL
Length:2,080
Mass (Da):232,268
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i424D3C489EF67087
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73650 Genomic DNA Translation: AAC62818.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73650 Genomic DNA Translation: AAC62818.1

3D structure databases

ProteinModelPortaliQ92215
SMRiQ92215
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92215

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00874

Family and domain databases

Gene3Di3.20.20.70, 1 hit
3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013785 Aldolase_TIM
IPR013565 DUF1729
IPR003965 Fatty_acid_synthase
IPR016452 Fatty_acid_Synthase_bsu_fun
IPR029069 HotDog_dom_sf
IPR039569 MaoC-like_dehydrat_N
IPR002539 MaoC-like_dom
IPR020801 PKS_acyl_transferase
IPR032088 SAT
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF08354 DUF1729, 1 hit
PF13452 MaoC_dehydrat_N, 1 hit
PF01575 MaoC_dehydratas, 1 hit
PF16073 SAT, 1 hit
PIRSFiPIRSF005562 FAS_yeast_beta, 1 hit
PRINTSiPR01483 FASYNTHASE
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF54637 SSF54637, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOXC_COCCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92215
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: February 1, 1997
Last modified: December 5, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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