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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene

TDH1

Organism
Candida albicans (strain WO-1) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.PROSITE-ProRule annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (TDH1)
  2. no protein annotated in this organism
  3. Phosphoglycerate mutase (CAWG_00961), Phosphoglycerate mutase (CAWG_04094)
  4. no protein annotated in this organism
  5. Pyruvate kinase (CAWG_04294)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei79NAD; via carbonyl oxygenBy similarity1
Active sitei151NucleophilePROSITE-ProRule annotation1
Sitei178Activates thiol group during catalysisBy similarity1
Binding sitei181Glyceraldehyde 3-phosphateBy similarity1
Binding sitei233Glyceraldehyde 3-phosphateBy similarity1
Binding sitei315NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 13NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell wall biogenesis/degradation, Glycolysis
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Protein family/group databases

MoonDBiQ92211 Curated
MoonProtiQ92211

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)
Short name:
GAPDH
Gene namesi
Name:TDH1
Synonyms:GAP, TDH3
ORF Names:CAWG_02997
OrganismiCandida albicans (strain WO-1) (Yeast)
Taxonomic identifieri294748 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000001429 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001455411 – 335Glyceraldehyde-3-phosphate dehydrogenaseAdd BLAST335

Proteomic databases

PRIDEiQ92211

2D gel databases

COMPLUYEAST-2DPAGEiQ92211

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92211
SMRiQ92211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 152Glyceraldehyde 3-phosphate bindingBy similarity3
Regioni210 – 211Glyceraldehyde 3-phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

OMAiNCVAPMA
OrthoDBiEOG092C2MZH

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q92211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKIGINGF GRIGRLVLRV ALGRKDIEVV AVNDPFIAPD YAAYMFKYDS
60 70 80 90 100
THGRYKGEVT ASGDDLVIDG HKIKVFQERD PANIPWGKSG VDYVIESTGV
110 120 130 140 150
FTKLEGAQKH IDAGAKKVII TAPSADAPMF VVGVNEDKYT PDLKIISNAS
160 170 180 190 200
CTTNCLAPLA KVVNDTFGIE EGLMTTVHSI TATQKTVDGP SHKDWRGGRT
210 220 230 240 250
ASGNIIPSST GAAKAVGKVI PELNGKLTGM SLRVPTTDVS VVDLTVRLKK
260 270 280 290 300
AASYEEIAQA IKKASEGPLK GVLGYTEDAV VSTDFLGSSY SSIFDEKAGI
310 320 330
LLSPTFVKLI SWYDNEYGYS TRVVDLLEHV AKASA
Length:335
Mass (Da):35,833
Last modified:October 19, 2011 - v2
Checksum:i24353A29CD3E332E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → V in AAC49800 (PubMed:9260938).Curated1
Sequence conflicti234V → L in AAC49800 (PubMed:9260938).Curated1
Sequence conflicti259Q → P in AAC49800 (PubMed:9260938).Curated1
Sequence conflicti322R → K in AAC49800 (PubMed:9260938).Curated1
Sequence conflicti332 – 335Missing in AAC49800 (PubMed:9260938).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72203 Genomic DNA Translation: AAC49800.1
CM000310 Genomic DNA Translation: EEQ44715.1

Genome annotation databases

EnsemblFungiiEEQ44715; EEQ44715; CAWG_02997

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72203 Genomic DNA Translation: AAC49800.1
CM000310 Genomic DNA Translation: EEQ44715.1

3D structure databases

ProteinModelPortaliQ92211
SMRiQ92211
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MoonDBiQ92211 Curated
MoonProtiQ92211

2D gel databases

COMPLUYEAST-2DPAGEiQ92211

Proteomic databases

PRIDEiQ92211

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ44715; EEQ44715; CAWG_02997

Phylogenomic databases

OMAiNCVAPMA
OrthoDBiEOG092C2MZH

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00184

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3P_CANAW
AccessioniPrimary (citable) accession number: Q92211
Secondary accession number(s): C4YP56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 19, 2011
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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