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Entry version 127 (07 Apr 2021)
Sequence version 2 (19 Oct 2011)
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Protein

Phosphoribosylaminoimidazole carboxylase

Gene

ADE2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route). This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi138 – 193ATPPROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.21, 1096

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00074;UER00130

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)
Alternative name(s):
AIR carboxylase
Short name:
AIRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADE2
Ordered Locus Names:CAALFM_C304520CA
ORF Names:CaO19.13327, CaO19.5906
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000185210, ADE2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:C3_04520C_A

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:196

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000750211 – 568Phosphoribosylaminoimidazole carboxylaseAdd BLAST568

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q92210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1218353, 1 interactor

STRING: functional protein association networks

More...
STRINGi
5476.C4YQK6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92210

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 298ATP-graspPROSITE-ProRule annotationAdd BLAST189

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2835, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011534_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92210

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITFDHEH

Database of Orthologous Groups

More...
OrthoDBi
945274at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit
3.40.50.7700, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01929, PurE_classI, 1 hit
MF_01928, PurK, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016301, Ade2_fungi/plant
IPR011761, ATP-grasp
IPR003135, ATP-grasp_carboxylate-amine
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR033747, PurE_ClassI
IPR000031, PurE_dom
IPR035893, PurE_sf
IPR005875, PurK
IPR040686, PurK_C
IPR011054, Rudment_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00731, AIRC, 1 hit
PF02222, ATP-grasp, 1 hit
PF17769, PurK_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001340, AIR_carboxylase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01001, AIRC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51246, SSF51246, 1 hit
SSF52255, SSF52255, 1 hit
SSF52440, SSF52440, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01162, purE, 1 hit
TIGR01161, purK, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975, ATP_GRASP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSKTVGILG GGQLGRMIVE AAHRLNIKTV ILDAAKSPAK QINALDDHVD
60 70 80 90 100
GSFTNYDSIV KLAEKADVLT VEIEHVDVDA LIKVQEKFPK VEIYPLPETI
110 120 130 140 150
RLIQDKYLQK NHLIKHDVAV TESVAVETNT VDDLLHIGEK FGYPYMLKSR
160 170 180 190 200
TLAYDGRGNF VVKDKSYCEK ALEFLKDRPL YAEKWCPFTK ELAVMVVRSL
210 220 230 240 250
EGEVFAYPTV ETIHENNICH LVYAPARIPD TLAKKASILA KNAVKSFLGC
260 270 280 290 300
GIFGVEMFLL ENNELLINEI APRPHNSGHY TIDACVTSQF EAHVRAVTGL
310 320 330 340 350
PMPKGFTEFS TSITNAIMLN VLGDKATPNK ELEICRRALE TPHASVYLYG
360 370 380 390 400
KTTRPERKMG HINVVTSSMQ DAESRLSYIL GDTTEIPKSL ATDKESPLVG
410 420 430 440 450
IIMGSDSDLP VMAVGARILK QFGVPFELTI VSAHRTPHRM SEYAIEAPKR
460 470 480 490 500
GLKCIIAGAG GAAHLPGMVA AMTPLPVIGV PVKGSTLDGV DSLHSIVQMP
510 520 530 540 550
RGIPVATVAI NNSTNAALLA IRILGAYDSK WLTEMNQYML NMETEVLGKA
560
ETLEEIGYED YLTDKLKK
Length:568
Mass (Da):62,413
Last modified:October 19, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEB63A6E0F193F44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233 – 234AK → GQ in AAC49755 (PubMed:9219341).Curated2
Sequence conflicti233 – 234AK → GQ in AAC49742 (PubMed:9200816).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti219C → W in strain: ATCC 32354 / B311. 1
Natural varianti248L → P in strain: ATCC 32354 / B311. 1
Natural varianti332L → S in strain: ATCC 32354 / B311. 1
Natural varianti352T → A in strain: ATCC 32354 / B311. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U69606 Genomic DNA Translation: AAC49755.1
U75582 Genomic DNA Translation: AAC49742.1
CP017625 Genomic DNA Translation: AOW28470.1

NCBI Reference Sequences

More...
RefSeqi
XP_723120.1, XM_718027.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3635259

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C304520CA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69606 Genomic DNA Translation: AAC49755.1
U75582 Genomic DNA Translation: AAC49742.1
CP017625 Genomic DNA Translation: AOW28470.1
RefSeqiXP_723120.1, XM_718027.1

3D structure databases

SMRiQ92210
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1218353, 1 interactor
STRINGi5476.C4YQK6

Proteomic databases

PRIDEiQ92210

Genome annotation databases

GeneIDi3635259
KEGGical:CAALFM_C304520CA

Organism-specific databases

CGDiCAL0000185210, ADE2
VEuPathDBiFungiDB:C3_04520C_A

Phylogenomic databases

eggNOGiKOG2835, Eukaryota
HOGENOMiCLU_011534_2_1_1
InParanoidiQ92210
OMAiITFDHEH
OrthoDBi945274at2759

Enzyme and pathway databases

UniPathwayiUPA00074;UER00130
BRENDAi4.1.1.21, 1096

Miscellaneous databases

PHI-baseiPHI:196

Protein Ontology

More...
PROi
PR:Q92210

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.50.7700, 1 hit
HAMAPiMF_01929, PurE_classI, 1 hit
MF_01928, PurK, 1 hit
InterProiView protein in InterPro
IPR016301, Ade2_fungi/plant
IPR011761, ATP-grasp
IPR003135, ATP-grasp_carboxylate-amine
IPR013815, ATP_grasp_subdomain_1
IPR016185, PreATP-grasp_dom_sf
IPR033747, PurE_ClassI
IPR000031, PurE_dom
IPR035893, PurE_sf
IPR005875, PurK
IPR040686, PurK_C
IPR011054, Rudment_hybrid_motif
PfamiView protein in Pfam
PF00731, AIRC, 1 hit
PF02222, ATP-grasp, 1 hit
PF17769, PurK_C, 1 hit
PIRSFiPIRSF001340, AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001, AIRC, 1 hit
SUPFAMiSSF51246, SSF51246, 1 hit
SSF52255, SSF52255, 1 hit
SSF52440, SSF52440, 1 hit
TIGRFAMsiTIGR01162, purE, 1 hit
TIGR01161, purK, 1 hit
PROSITEiView protein in PROSITE
PS50975, ATP_GRASP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUR6_CANAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92210
Secondary accession number(s): A0A1D8PK45, P78597, Q5ANJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 19, 2011
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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