UniProtKB - Q921Z5 (TFIP8_MOUSE)
Protein
Tumor necrosis factor alpha-induced protein 8
Gene
Tnfaip8
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).By similarity
GO - Molecular functioni
GO - Biological processi
- defense response to Gram-positive bacterium Source: MGI
- interleukin-1 beta production Source: MGI
- positive regulation of apoptotic process Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-1483255, PI Metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor alpha-induced protein 8Short name: TNF alpha-induced protein 8 |
Gene namesi | Name:Tnfaip8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2147191, Tnfaip8 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285719 | 1 – 198 | Tumor necrosis factor alpha-induced protein 8Add BLAST | 198 |
Proteomic databases
EPDi | Q921Z5 |
jPOSTi | Q921Z5 |
PaxDbi | Q921Z5 |
PeptideAtlasi | Q921Z5 |
PRIDEi | Q921Z5 |
PTM databases
PhosphoSitePlusi | Q921Z5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000062210, Expressed in proximal tubule and 300 other tissues |
ExpressionAtlasi | Q921Z5, baseline and differential |
Genevisiblei | Q921Z5, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 223149, 22 interactors |
IntActi | Q921Z5, 1 interactor |
STRINGi | 10090.ENSMUSP00000119041 |
Miscellaneous databases
RNActi | Q921Z5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q921Z5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 49 – 83 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the TNFAIP8 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S00N, Eukaryota |
GeneTreei | ENSGT00390000003488 |
HOGENOMi | CLU_1942921_0_0_1 |
InParanoidi | Q921Z5 |
OrthoDBi | 1284744at2759 |
Family and domain databases
Gene3Di | 1.20.1440.160, 1 hit |
InterProi | View protein in InterPro IPR008477, TNFAIP8-like IPR038355, TNFAIP8_sf |
PANTHERi | PTHR12757, PTHR12757, 1 hit |
Pfami | View protein in Pfam PF05527, DUF758, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q921Z5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSEAEEPRE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTKE YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVE YTFDRNVLSR LLNECRELLH EIIQRHLTAK
160 170 180 190
SHGRVNNVFD HFSDCDFLAA LYNPFGKFKP HLQKLCDGIN KMLDEENI
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z325 | D3Z325_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 212 | Annotation score: | ||
D3YWJ5 | D3YWJ5_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 188 | Annotation score: | ||
D3Z0Q1 | D3Z0Q1_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 114 | Annotation score: | ||
J3QM73 | J3QM73_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 166 | Annotation score: | ||
D3Z312 | D3Z312_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 212 | Annotation score: | ||
J3QNA5 | J3QNA5_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 100 | Annotation score: | ||
D3Z205 | D3Z205_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 77 | Annotation score: | ||
J3QNB8 | J3QNB8_MOUSE | Tumor necrosis factor alpha-induced... | Tnfaip8 | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | K → Q in BAE29996 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 104 | K → N in BAE30559 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 104 | K → N in BAE31209 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 104 | K → N in BAE29567 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 190 | N → K in BAC41167 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024900 | 1 – 11 | MLSEAEEPREV → M in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_024901 | 119 – 198 | VEYTF…DEENI → IVIDLQELNLRQSNRMLRKA KKTVHLKS in isoform 2. 1 PublicationAdd BLAST | 80 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090316 mRNA Translation: BAC41167.1 AK149901 mRNA Translation: BAE29154.1 AK150445 mRNA Translation: BAE29567.1 AK150965 mRNA Translation: BAE29996.1 AK151622 mRNA Translation: BAE30559.1 AK152426 mRNA Translation: BAE31209.1 AK163339 mRNA Translation: BAE37307.1 BC009090 mRNA Translation: AAH09090.1 |
CCDSi | CCDS50287.1 [Q921Z5-2] |
RefSeqi | NP_001171231.1, NM_001177760.1 [Q921Z5-2] NP_598892.2, NM_134131.2 |
Genome annotation databases
Ensembli | ENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2] |
GeneIDi | 106869 |
KEGGi | mmu:106869 |
UCSCi | uc008ewq.2, mouse [Q921Z5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090316 mRNA Translation: BAC41167.1 AK149901 mRNA Translation: BAE29154.1 AK150445 mRNA Translation: BAE29567.1 AK150965 mRNA Translation: BAE29996.1 AK151622 mRNA Translation: BAE30559.1 AK152426 mRNA Translation: BAE31209.1 AK163339 mRNA Translation: BAE37307.1 BC009090 mRNA Translation: AAH09090.1 |
CCDSi | CCDS50287.1 [Q921Z5-2] |
RefSeqi | NP_001171231.1, NM_001177760.1 [Q921Z5-2] NP_598892.2, NM_134131.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5JXD | X-ray | 2.03 | A | 1-198 | [»] | |
SMRi | Q921Z5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 223149, 22 interactors |
IntActi | Q921Z5, 1 interactor |
STRINGi | 10090.ENSMUSP00000119041 |
PTM databases
PhosphoSitePlusi | Q921Z5 |
Proteomic databases
EPDi | Q921Z5 |
jPOSTi | Q921Z5 |
PaxDbi | Q921Z5 |
PeptideAtlasi | Q921Z5 |
PRIDEi | Q921Z5 |
Protocols and materials databases
Antibodypediai | 25539, 243 antibodies |
DNASUi | 106869 |
Genome annotation databases
Ensembli | ENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2] |
GeneIDi | 106869 |
KEGGi | mmu:106869 |
UCSCi | uc008ewq.2, mouse [Q921Z5-2] |
Organism-specific databases
CTDi | 25816 |
MGIi | MGI:2147191, Tnfaip8 |
Phylogenomic databases
eggNOGi | ENOG502S00N, Eukaryota |
GeneTreei | ENSGT00390000003488 |
HOGENOMi | CLU_1942921_0_0_1 |
InParanoidi | Q921Z5 |
OrthoDBi | 1284744at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-1483255, PI Metabolism |
Miscellaneous databases
BioGRID-ORCSi | 106869, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tnfaip8, mouse |
PROi | PR:Q921Z5 |
RNActi | Q921Z5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062210, Expressed in proximal tubule and 300 other tissues |
ExpressionAtlasi | Q921Z5, baseline and differential |
Genevisiblei | Q921Z5, MM |
Family and domain databases
Gene3Di | 1.20.1440.160, 1 hit |
InterProi | View protein in InterPro IPR008477, TNFAIP8-like IPR038355, TNFAIP8_sf |
PANTHERi | PTHR12757, PTHR12757, 1 hit |
Pfami | View protein in Pfam PF05527, DUF758, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TFIP8_MOUSE | |
Accessioni | Q921Z5Primary (citable) accession number: Q921Z5 Secondary accession number(s): Q3TQS5 Q8BTH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families