UniProtKB - Q921Z5 (TFIP8_MOUSE)

BLAST

>sp|Q921Z5|TFIP8_MOUSE Tumor necrosis factor alpha-induced protein 8 OS=Mus musculus OX=10090 GN=Tnfaip8 PE=1 SV=1
MLSEAEEPREVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTKE
YTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVE
YTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKP
HLQKLCDGINKMLDEENI

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History
Entry version 111 (12 Sep 2018)
Sequence version 1 (01 Dec 2001)
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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

Tnfaip8

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).By similarity

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

defense response to Gram-positive bacterium
Source: MGI
Inferred from mutant phenotypeⁱ
- 20824097
interleukin-1 beta production
Source: MGI
Inferred from mutant phenotypeⁱ
- 20824097
positive regulation of apoptotic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1483255 PI Metabolism

Reactomeⁱ

R-MMU-1483255 PI Metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor alpha-induced protein 8 Short name: TNF alpha-induced protein 8
Gene namesⁱ	Name:Tnfaip8
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:2147191 Tnfaip8

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285719	1 – 198	Tumor necrosis factor alpha-induced protein 8Add BLAST		198

Proteomic databases

EPDⁱ	Q921Z5
PaxDbⁱ	Q921Z5
PeptideAtlas More...PeptideAtlasⁱ	Q921Z5
PRIDEⁱ	Q921Z5

PTM databases

PhosphoSitePlusⁱ	Q921Z5

PhosphoSitePlusⁱ

Q921Z5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000062210 Expressed in 284 organ(s), highest expression level in proximal tubule
CleanExⁱ	MM_TNFAIP8
ExpressionAtlasⁱ	Q921Z5 baseline and differential
Genevisibleⁱ	Q921Z5 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000119041

STRINGⁱ

10090.ENSMUSP00000119041

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	19 – 33	Combined sources	15
Helixⁱ	35 – 39	Combined sources	5
Turnⁱ	40 – 42	Combined sources	3
Helixⁱ	45 – 62	Combined sources	18
Helixⁱ	65 – 87	Combined sources	23
Helixⁱ	93 – 118	Combined sources	26
Helixⁱ	125 – 143	Combined sources	19
Turnⁱ	144 – 146	Combined sources	3
Helixⁱ	149 – 162	Combined sources	14
Helixⁱ	165 – 171	Combined sources	7
Helixⁱ	179 – 194	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q921Z5
SMRⁱ	Q921Z5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	49 – 83	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the TNFAIP8 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9 Eukaryota ENOG4111KN4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003488
HOGENOMⁱ	HOG000007708
HOVERGENⁱ	HBG053286
InParanoidⁱ	Q921Z5

Family and domain databases

Gene3Dⁱ	1.20.1440.160, 1 hit
InterProⁱ	View protein in InterPro IPR008477 TNFAIP8-like IPR038355 TNFAIP8_sf
PANTHERⁱ	PTHR12757 PTHR12757, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05527 DUF758, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q921Z5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSEAEEPRE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV 
        60         70         80         90        100
LDELYRVTKE YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME 
       110        120        130        140        150
KFKKKVHQLA MTVVSFHQVE YTFDRNVLSR LLNECRELLH EIIQRHLTAK 
       160        170        180        190 
SHGRVNNVFD HFSDCDFLAA LYNPFGKFKP HLQKLCDGIN KMLDEENI

Length:198

Mass (Da):22,960

Last modified:December 1, 2001 - v1

Checksum:ⁱB6E8DCC5CDC25F6A

Isoform 2 (identifier: Q921Z5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-11: MLSEAEEPREV → M
119-198: VEYTFDRNVL...INKMLDEENI → IVIDLQELNLRQSNRMLRKAKKTVHLKS

« Hide

        10         20         30         40         50
MATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTKE 
        60         70         80         90        100
YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME KFKKKVHQLA 
       110        120        130 
MTVVSFHQIV IDLQELNLRQ SNRMLRKAKK TVHLKS

Show »

Length:136

Mass (Da):15,721

Checksum:ⁱ6889DEA2B75D0313

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z325	D3Z325_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	212	Annotation score:
D3YWJ5	D3YWJ5_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	188	Annotation score:
D3Z0Q1	D3Z0Q1_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	114	Annotation score:
D3Z312	D3Z312_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	212	Annotation score:
J3QM73	J3QM73_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	166	Annotation score:
J3QNA5	J3QNA5_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	100	Annotation score:
D3Z205	D3Z205_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	77	Annotation score:
J3QNB8	J3QNB8_MOUSE	Tumor necrosis factor alpha-induced... Tumor necrosis factor alpha-induced protein 8	Tnfaip8	122	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	19	K → Q in BAE29996 (PubMed:16141072).Curated	1
Sequence conflictⁱ	104	K → N in BAE30559 (PubMed:16141072).Curated	1
Sequence conflictⁱ	104	K → N in BAE31209 (PubMed:16141072).Curated	1
Sequence conflictⁱ	104	K → N in BAE29567 (PubMed:16141072).Curated	1
Sequence conflictⁱ	190	N → K in BAC41167 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024900	1 – 11	MLSEAEEPREV → M in isoform 2. 1 PublicationAdd BLAST		11
Alternative sequenceⁱVSP_024901	119 – 198	VEYTF…DEENI → IVIDLQELNLRQSNRMLRKA KKTVHLKS in isoform 2. 1 PublicationAdd BLAST		80

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090316 mRNA Translation: BAC41167.1 AK149901 mRNA Translation: BAE29154.1 AK150445 mRNA Translation: BAE29567.1 AK150965 mRNA Translation: BAE29996.1 AK151622 mRNA Translation: BAE30559.1 AK152426 mRNA Translation: BAE31209.1 AK163339 mRNA Translation: BAE37307.1 BC009090 mRNA Translation: AAH09090.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS50287.1 [Q921Z5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171231.1, NM_001177760.1 [Q921Z5-2] NP_598892.2, NM_134131.2
UniGeneⁱ	Mm.27740

Genome annotation databases

Ensemblⁱ	ENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2]
GeneIDⁱ	106869
KEGGⁱ	mmu:106869
UCSC genome browser More...UCSCⁱ	uc008ewq.2 mouse [Q921Z5-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q921Z5	Tumor necrosis factor alpha-induced protein 8		MOUSE		212	UniRef100_Q921Z5
Tumor necrosis factor alpha-induced protein 8 (Fragment)		MOUSE		77
Tumor necrosis factor alpha-induced protein 8 (Fragment)		MOUSE		114

Protein	Similar proteins		Species	Score	Length	Source
Q921Z5	Tumor necrosis factor alpha-induced protein 8		MOUSE		212	UniRef90_Q921Z5
tumor necrosis factor alpha-induced protein 8 isoform X1		MESAU		213
Uncharacterized protein		NEOLE		192
TNF alpha-induced protein 8		RAT		166
UPI00042AB2DB		PERMB		166
+4

Protein	Similar proteins		Species	Score	Length	Source
Q921Z5	Tumor necrosis factor alpha-induced protein 8		HUMAN		198	UniRef50_O95379
Tumor necrosis factor alpha-induced protein 8		PONAB		198
Tumor necrosis factor alpha-induced protein 8		BOVIN		198
Tumor necrosis factor alpha-induced protein 8-like protein 1		DANRE		186
Tumor necrosis factor alpha-induced protein 8-like protein 2		RAT		184
+882
Q921Z5-2	Uncharacterized protein		ICTTR		126	UniRef50_Q921Z5-2
Tumor necrosis factor, alpha-induced protein 8		HETGA		130

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090316 mRNA Translation: BAC41167.1 AK149901 mRNA Translation: BAE29154.1 AK150445 mRNA Translation: BAE29567.1 AK150965 mRNA Translation: BAE29996.1 AK151622 mRNA Translation: BAE30559.1 AK152426 mRNA Translation: BAE31209.1 AK163339 mRNA Translation: BAE37307.1 BC009090 mRNA Translation: AAH09090.1
CCDSⁱ	CCDS50287.1 [Q921Z5-2]
RefSeqⁱ	NP_001171231.1, NM_001177760.1 [Q921Z5-2] NP_598892.2, NM_134131.2
UniGeneⁱ	Mm.27740

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5JXD	X-ray	2.03	A	1-198	[»]
ProteinModelPortalⁱ	Q921Z5
SMRⁱ	Q921Z5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000119041

STRINGⁱ

10090.ENSMUSP00000119041

PTM databases

PhosphoSitePlusⁱ	Q921Z5

PhosphoSitePlusⁱ

Q921Z5

Proteomic databases

EPDⁱ	Q921Z5
PaxDbⁱ	Q921Z5
PeptideAtlasⁱ	Q921Z5
PRIDEⁱ	Q921Z5

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	106869
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2]
GeneIDⁱ	106869
KEGGⁱ	mmu:106869
UCSCⁱ	uc008ewq.2 mouse [Q921Z5-2]

Organism-specific databases

CTDⁱ	25816
MGIⁱ	MGI:2147191 Tnfaip8

Phylogenomic databases

eggNOGⁱ	ENOG410IEG9 Eukaryota ENOG4111KN4 LUCA
GeneTreeⁱ	ENSGT00390000003488
HOGENOMⁱ	HOG000007708
HOVERGENⁱ	HBG053286
InParanoidⁱ	Q921Z5

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1483255 PI Metabolism

Reactomeⁱ

R-MMU-1483255 PI Metabolism

Miscellaneous databases

ChiTaRSⁱ	Tnfaip8 mouse
Protein Ontology More...PROⁱ	PR:Q921Z5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000062210 Expressed in 284 organ(s), highest expression level in proximal tubule
CleanExⁱ	MM_TNFAIP8
ExpressionAtlasⁱ	Q921Z5 baseline and differential
Genevisibleⁱ	Q921Z5 MM

Family and domain databases

Gene3Dⁱ	1.20.1440.160, 1 hit
InterProⁱ	View protein in InterPro IPR008477 TNFAIP8-like IPR038355 TNFAIP8_sf
PANTHERⁱ	PTHR12757 PTHR12757, 1 hit
Pfamⁱ	View protein in Pfam PF05527 DUF758, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFIP8_MOUSE
Accessionⁱ	Q921Z5Primary (citable) accession number: Q921Z5 Secondary accession number(s): Q3TQS5 , Q3U9V7, Q3UBG8, Q8BTH4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q921Z5 (TFIP8_MOUSE)

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Tumor necrosis factor alpha-induced protein 8

Tnfaip8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ