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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

Tnfaip8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: MGI
  • interleukin-1 beta production Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-1483255 PI Metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Gene namesi
Name:Tnfaip8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2147191 Tnfaip8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002857191 – 198Tumor necrosis factor alpha-induced protein 8Add BLAST198

Proteomic databases

EPDiQ921Z5
PaxDbiQ921Z5
PeptideAtlasiQ921Z5
PRIDEiQ921Z5

PTM databases

PhosphoSitePlusiQ921Z5

Expressioni

Gene expression databases

BgeeiENSMUSG00000062210 Expressed in 284 organ(s), highest expression level in proximal tubule
CleanExiMM_TNFAIP8
ExpressionAtlasiQ921Z5 baseline and differential
GenevisibleiQ921Z5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119041

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ921Z5
SMRiQ921Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 83Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ921Z5

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q921Z5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSEAEEPRE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTKE YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVE YTFDRNVLSR LLNECRELLH EIIQRHLTAK
160 170 180 190
SHGRVNNVFD HFSDCDFLAA LYNPFGKFKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):22,960
Last modified:December 1, 2001 - v1
Checksum:iB6E8DCC5CDC25F6A
GO
Isoform 2 (identifier: Q921Z5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MLSEAEEPREV → M
     119-198: VEYTFDRNVL...INKMLDEENI → IVIDLQELNLRQSNRMLRKAKKTVHLKS

Show »
Length:136
Mass (Da):15,721
Checksum:i6889DEA2B75D0313
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z325D3Z325_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
212Annotation score:
D3YWJ5D3YWJ5_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
188Annotation score:
D3Z0Q1D3Z0Q1_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
114Annotation score:
D3Z312D3Z312_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
212Annotation score:
J3QM73J3QM73_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
166Annotation score:
J3QNA5J3QNA5_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
100Annotation score:
D3Z205D3Z205_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
77Annotation score:
J3QNB8J3QNB8_MOUSE
Tumor necrosis factor alpha-induced...
Tnfaip8
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19K → Q in BAE29996 (PubMed:16141072).Curated1
Sequence conflicti104K → N in BAE30559 (PubMed:16141072).Curated1
Sequence conflicti104K → N in BAE31209 (PubMed:16141072).Curated1
Sequence conflicti104K → N in BAE29567 (PubMed:16141072).Curated1
Sequence conflicti190N → K in BAC41167 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0249001 – 11MLSEAEEPREV → M in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_024901119 – 198VEYTF…DEENI → IVIDLQELNLRQSNRMLRKA KKTVHLKS in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090316 mRNA Translation: BAC41167.1
AK149901 mRNA Translation: BAE29154.1
AK150445 mRNA Translation: BAE29567.1
AK150965 mRNA Translation: BAE29996.1
AK151622 mRNA Translation: BAE30559.1
AK152426 mRNA Translation: BAE31209.1
AK163339 mRNA Translation: BAE37307.1
BC009090 mRNA Translation: AAH09090.1
CCDSiCCDS50287.1 [Q921Z5-2]
RefSeqiNP_001171231.1, NM_001177760.1 [Q921Z5-2]
NP_598892.2, NM_134131.2
UniGeneiMm.27740

Genome annotation databases

EnsembliENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2]
GeneIDi106869
KEGGimmu:106869
UCSCiuc008ewq.2 mouse [Q921Z5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090316 mRNA Translation: BAC41167.1
AK149901 mRNA Translation: BAE29154.1
AK150445 mRNA Translation: BAE29567.1
AK150965 mRNA Translation: BAE29996.1
AK151622 mRNA Translation: BAE30559.1
AK152426 mRNA Translation: BAE31209.1
AK163339 mRNA Translation: BAE37307.1
BC009090 mRNA Translation: AAH09090.1
CCDSiCCDS50287.1 [Q921Z5-2]
RefSeqiNP_001171231.1, NM_001177760.1 [Q921Z5-2]
NP_598892.2, NM_134131.2
UniGeneiMm.27740

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JXDX-ray2.03A1-198[»]
ProteinModelPortaliQ921Z5
SMRiQ921Z5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119041

PTM databases

PhosphoSitePlusiQ921Z5

Proteomic databases

EPDiQ921Z5
PaxDbiQ921Z5
PeptideAtlasiQ921Z5
PRIDEiQ921Z5

Protocols and materials databases

DNASUi106869
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179937; ENSMUSP00000136030; ENSMUSG00000062210 [Q921Z5-2]
GeneIDi106869
KEGGimmu:106869
UCSCiuc008ewq.2 mouse [Q921Z5-2]

Organism-specific databases

CTDi25816
MGIiMGI:2147191 Tnfaip8

Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
HOVERGENiHBG053286
InParanoidiQ921Z5

Enzyme and pathway databases

ReactomeiR-MMU-1483255 PI Metabolism

Miscellaneous databases

ChiTaRSiTnfaip8 mouse
PROiPR:Q921Z5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062210 Expressed in 284 organ(s), highest expression level in proximal tubule
CleanExiMM_TNFAIP8
ExpressionAtlasiQ921Z5 baseline and differential
GenevisibleiQ921Z5 MM

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFIP8_MOUSE
AccessioniPrimary (citable) accession number: Q921Z5
Secondary accession number(s): Q3TQS5
, Q3U9V7, Q3UBG8, Q8BTH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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