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UniProtKB - Q921V7 (CTL3_MOUSE)
Protein
Choline transporter-like protein 3
Gene
Slc44a3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- transmembrane transport Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-1483191, Synthesis of PC R-MMU-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Names & Taxonomyi
Protein namesi | Recommended name: Choline transporter-like protein 3Alternative name(s): Solute carrier family 44 member 3 |
Gene namesi | Name:Slc44a3 Synonyms:Ctl3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384860, Slc44a3 |
VEuPathDBi | HostDB:ENSMUSG00000039865 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 37 – 57 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 337 – 357 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 381 – 401 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 537 – 557 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191721 | 1 – 656 | Choline transporter-like protein 3Add BLAST | 656 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 506 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 524 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 559 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q921V7 |
PaxDbi | Q921V7 |
PeptideAtlasi | Q921V7 |
PRIDEi | Q921V7 |
ProteomicsDBi | 285220 |
PTM databases
GlyGeni | Q921V7, 5 sites |
PhosphoSitePlusi | Q921V7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039865, Expressed in dorsal pancreas and 171 other tissues |
Genevisiblei | Q921V7, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 229459, 1 interactor |
STRINGi | 10090.ENSMUSP00000040210 |
Miscellaneous databases
RNActi | Q921V7, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 634 – 656 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Belongs to the CTL (choline transporter-like) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1362, Eukaryota |
GeneTreei | ENSGT00940000160336 |
HOGENOMi | CLU_017181_2_0_1 |
InParanoidi | Q921V7 |
OMAi | QCLGAEY |
OrthoDBi | 329225at2759 |
PhylomeDBi | Q921V7 |
TreeFami | TF313325 |
Family and domain databases
InterProi | View protein in InterPro IPR007603, Choline_transptr-like |
PANTHERi | PTHR12385, PTHR12385, 1 hit |
Pfami | View protein in Pfam PF04515, Choline_transpo, 1 hit |
i Sequence
Sequence statusi: Complete.
Q921V7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGTMQCLGA EYLVSAEKTR QREWRPQIYR KCTDTPWLVL FFLFWTGLVF
60 70 80 90 100
IMGYSVVAGA AGRLLFGYDS FGNVCGKKNS PVEGAPLSGQ DMTLKKHVFF
110 120 130 140 150
MNACNLEVKD RGLGPTALCV SSCPEKQLDT LEEVQLFANI NGSFLCVYSL
160 170 180 190 200
NSFNYTQSSS ADTLCPRLPV PPSKPFPLFN RCIPQTPECY SLFASVLIND
210 220 230 240 250
ADALHRILSG IMAGRDTILG LCVFTFALSL AMLFAFRFIS TLLIHIIISL
260 270 280 290 300
VILGLLFVCG VLWWLYYDYT NDLSTELDTE KENMNCMLAF AIISTVVTVL
310 320 330 340 350
LLALIFTLRK RIKLTVELLH VTNKAISSCP FLLFQPLWTC AILIFFWVLW
360 370 380 390 400
VAVLLSLGTA GTAQVMEGGQ VEYKPLSGIR YMWWYHLIGL IWTSEFILAC
410 420 430 440 450
QRMTVAGAMV ACYFNRNQND PPARPILSSL FVLFCYHQGT AVKGSFLLTV
460 470 480 490 500
TRIPRVIFMC IYSTLKEPQR SAWSRGEFRC SHCGLWCLLK YLYHLNQDAY
510 520 530 540 550
TATAINGTDF CTSAKDAHTI IAKNSSHLTS VNCFGNFVIF LGKVLVVCFS
560 570 580 590 600
IFGGLMAFNY SRALQVWAIP LLLVAFFACV VAHSFLSVFE TALDILFLCF
610 620 630 640 650
AVDLETNDGS SEKPYFMDPG FLSVIKRTNN LNNAKSQGQK DALPNEEGTE
LQPIVR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105336 Genomic DNA No translation available. AC115727 Genomic DNA No translation available. CH466532 Genomic DNA Translation: EDL12341.1 BC010552 mRNA Translation: AAH10552.1 BC025548 mRNA Translation: AAH25548.1 |
CCDSi | CCDS51060.1 |
RefSeqi | NP_663369.2, NM_145394.3 |
Genome annotation databases
Ensembli | ENSMUST00000039197; ENSMUSP00000040210; ENSMUSG00000039865 |
GeneIDi | 213603 |
KEGGi | mmu:213603 |
UCSCi | uc008rdz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC105336 Genomic DNA No translation available. AC115727 Genomic DNA No translation available. CH466532 Genomic DNA Translation: EDL12341.1 BC010552 mRNA Translation: AAH10552.1 BC025548 mRNA Translation: AAH25548.1 |
CCDSi | CCDS51060.1 |
RefSeqi | NP_663369.2, NM_145394.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 229459, 1 interactor |
STRINGi | 10090.ENSMUSP00000040210 |
PTM databases
GlyGeni | Q921V7, 5 sites |
PhosphoSitePlusi | Q921V7 |
Proteomic databases
MaxQBi | Q921V7 |
PaxDbi | Q921V7 |
PeptideAtlasi | Q921V7 |
PRIDEi | Q921V7 |
ProteomicsDBi | 285220 |
Protocols and materials databases
Antibodypediai | 33668, 58 antibodies from 15 providers |
DNASUi | 213603 |
Genome annotation databases
Ensembli | ENSMUST00000039197; ENSMUSP00000040210; ENSMUSG00000039865 |
GeneIDi | 213603 |
KEGGi | mmu:213603 |
UCSCi | uc008rdz.2, mouse |
Organism-specific databases
CTDi | 126969 |
MGIi | MGI:2384860, Slc44a3 |
VEuPathDBi | HostDB:ENSMUSG00000039865 |
Phylogenomic databases
eggNOGi | KOG1362, Eukaryota |
GeneTreei | ENSGT00940000160336 |
HOGENOMi | CLU_017181_2_0_1 |
InParanoidi | Q921V7 |
OMAi | QCLGAEY |
OrthoDBi | 329225at2759 |
PhylomeDBi | Q921V7 |
TreeFami | TF313325 |
Enzyme and pathway databases
Reactomei | R-MMU-1483191, Synthesis of PC R-MMU-425366, Transport of bile salts and organic acids, metal ions and amine compounds |
Miscellaneous databases
BioGRID-ORCSi | 213603, 2 hits in 64 CRISPR screens |
ChiTaRSi | Slc44a3, mouse |
PROi | PR:Q921V7 |
RNActi | Q921V7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039865, Expressed in dorsal pancreas and 171 other tissues |
Genevisiblei | Q921V7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007603, Choline_transptr-like |
PANTHERi | PTHR12385, PTHR12385, 1 hit |
Pfami | View protein in Pfam PF04515, Choline_transpo, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CTL3_MOUSE | |
Accessioni | Q921V7Primary (citable) accession number: Q921V7 Secondary accession number(s): G5E8A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | September 18, 2013 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families