Smoothelin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin binding Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 18678771

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• negative regulation of systemic arterial blood pressure Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18678771
• positive regulation of cardiac muscle contraction Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 18678771

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin binding Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 18678771

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA 
        60         70         80         90        100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR 
       110        120        130        140        150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA 
       160        170        180        190        200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS 
       210        220        230        240        250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM 
       260        270        280        290        300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL 
       310        320        330        340        350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP 
       360        370        380        390        400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH 
       410        420        430        440        450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE 
       460        470        480        490        500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS 
       510        520        530        540        550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP 
       560        570        580        590        600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF 
       610        620        630        640        650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR 
       660        670        680        690        700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS 
       710        720        730        740        750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE 
       760        770        780        790        800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG 
       810        820        830        840        850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE 
       860        870        880        890        900
AFDYGQLSPQ NRRQNFEMAF SSAEMLVDCV PLVEVEDMMI MGKKPDPKCV 
       910        920 
FTYVQSLYNH LRRHELRLRG KNV                              

        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA 
        60         70         80         90        100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR 
       110        120        130        140        150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA 
       160        170        180        190        200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS 
       210        220        230        240        250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM 
       260        270        280        290        300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL 
       310        320        330        340        350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP 
       360        370        380        390        400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH 
       410        420        430        440        450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE 
       460        470        480        490        500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS 
       510        520        530        540        550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP 
       560        570        580        590        600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF 
       610        620        630        640        650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR 
       660        670        680        690        700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS 
       710        720        730        740        750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE 
       760        770        780        790        800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG 
       810        820        830        840        850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE 
       860        870        880        890        900
AFDYGQLSPQ NRRQNFEMAF SSAETHADCP QLLDTEDMVR LREPDWKCVY 
       910        920 
TYIQEFYRCL VQKGLVKTKK S                                

        10         20         30         40         50
MKTTFTIEIK DGRGQASTGR VLLPTGNQRA ELTLGLRAPP TLLSTSSGGK 
        60         70         80         90        100
NTITHISNPG TVTRLGSVTH VTTFSHASPG NRGGCNFKME PDPAEPPSTT 
       110        120        130        140        150
VEAANGAEQA RVDKGPEGRS PLSAEELTAI EDEGVLDKML DQTTNFEERK 
       160        170        180        190        200
LIRAALRELR QRKRDQRDKE RERRLREARA RPGESRSNVA TETTTRHSQR 
       210        220        230        240        250
AADGSTVGTV TKTERLVHSN DGTQTARTTT VESSFMRRLE NGSSSSSTTT 
       260        270        280        290        300
TTVQTKSFSS SSSSSSSKKM GSIFDREDQT SSRPGSLAAL ERRQAEKKKE 
       310        320        330        340        350
LMKAQSLPKT SASQARKAMI EKLEKEGSAG GPGTPRTAVQ RSTSFGVPNA 
       360        370        380        390        400
NSIKQMLLDW CRAKTRGYEH VDIQNFSSSW SDGMAFCALV HNFFPEAFDY 
       410        420        430        440        450
GQLSPQNRRQ NFEMAFSSAE MLVDCVPLVE VEDMMIMGKK PDPKCVFTYV 
       460 
QSLYNHLRRH ELRLRGKNV                                   

        10         20         30         40         50
MKTTFTIEIK DGRGQASTGR VLLPTGNQRA ELTLGLRAPP TLLSTSSGGK 
        60         70         80         90        100
NTITHISNPG TVTRLGSVTH VTTFSHASPG NRGGCNFKME PDPAEPPSTT 
       110        120        130        140        150
VEAANGAEQA RVDKGPEGRS PLSAEELTAI EDEGVLDKML DQTTNFEERK 
       160        170        180        190        200
LIRAALRELR QRKRDQRDKE RERRLREARA RPGESRSNVA TETTTRHSQR 
       210        220        230        240        250
AADGSTVGTV TKTERLVHSN DGTQTARTTT VESSFMRRLE NGSSSSSTTT 
       260        270        280        290        300
TTVQTKSFSS SSSSSSSKKM GSIFDREDQT SSRPGSLAAL ERRQAEKKKE 
       310        320        330        340        350
LMKAQSLPKT SASQARKAMI EKLEKEGSAG GPGTPRTAVQ RSTSFGVPNA 
       360        370        380        390        400
NSIKQMLLDW CRAKTRGYEH VDIQNFSSSW SDGMAFCALV HNFFPEAFDY 
       410        420        430        440        450
GQLSPQNRRQ NFEMAFSSAE THADCPQLLD TEDMVRLREP DWKCVYTYIQ 
       460 
EFYRCLVQKG LVKTKKS                                     

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families