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Entry version 120 (12 Aug 2020)
Sequence version 2 (05 Feb 2008)
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Protein

Smoothelin

Gene

Smtn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural protein of the cytoskeleton.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Smoothelin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Smtn
Synonyms:Smsmo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1354727, Smtn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003185932 – 923SmoothelinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei359PhosphothreonineBy similarity1
Modified residuei372PhosphothreonineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei641PhosphoserineCombined sources1
Modified residuei735PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Isoform L2 (identifier: Q921U8-2)
Modified residuei372PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q921U8

PeptideAtlas

More...
PeptideAtlasi
Q921U8

PRoteomics IDEntifications database

More...
PRIDEi
Q921U8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q921U8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q921U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000020439, Expressed in urinary bladder and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q921U8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q921U8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
205923, 4 interactors

Protein interaction database and analysis system

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IntActi
Q921U8, 3 interactors

Molecular INTeraction database

More...
MINTi
Q921U8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020721

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q921U8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q921U8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini805 – 912Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 89Sequence analysisAdd BLAST66
Coiled coili601 – 628Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 272Pro-richAdd BLAST79
Compositional biasi367 – 391Ser-richAdd BLAST25
Compositional biasi645 – 709Thr-richAdd BLAST65
Compositional biasi697 – 740Ser-richAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the smoothelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4678, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161655

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014660_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q921U8

Identification of Orthologs from Complete Genome Data

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OMAi
QNREPTP

Database of Orthologous Groups

More...
OrthoDBi
168604at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316716

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR022189, SMTN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12510, Smoothelin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform L1 (identifier: Q921U8-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA
60 70 80 90 100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR
110 120 130 140 150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA
160 170 180 190 200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS
210 220 230 240 250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM
260 270 280 290 300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL
310 320 330 340 350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP
360 370 380 390 400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH
410 420 430 440 450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE
460 470 480 490 500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS
510 520 530 540 550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP
560 570 580 590 600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF
610 620 630 640 650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR
660 670 680 690 700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS
710 720 730 740 750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE
760 770 780 790 800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG
810 820 830 840 850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE
860 870 880 890 900
AFDYGQLSPQ NRRQNFEMAF SSAEMLVDCV PLVEVEDMMI MGKKPDPKCV
910 920
FTYVQSLYNH LRRHELRLRG KNV
Length:923
Mass (Da):100,289
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E70E413C8B487C7
GO
Isoform L2 (identifier: Q921U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:921
Mass (Da):100,135
Checksum:i019B4D29FC07BACF
GO
Isoform S1 (identifier: Q921U8-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.

Show »
Length:469
Mass (Da):51,657
Checksum:i7DB57BDE4A611CA1
GO
Isoform S2 (identifier: Q921U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:467
Mass (Da):51,503
Checksum:iCE56CFFC6761D5A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVS1D3YVS1_MOUSE
Smoothelin
Smtn
436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3Q3D3Z3Q3_MOUSE
Smoothelin
Smtn
946Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZ10D3YZ10_MOUSE
Smoothelin
Smtn
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z525D3Z525_MOUSE
Smoothelin
Smtn
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173P → S in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti173P → S in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti173P → S in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti173P → S in AAF25577 (Ref. 3) Curated1
Sequence conflicti173P → S in AAF25578 (Ref. 3) Curated1
Sequence conflicti379Missing in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti441P → Q in BAE41853 (PubMed:16141072).Curated1
Sequence conflicti448T → N in BAC27188 (PubMed:16141072).Curated1
Sequence conflicti450E → G in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti711S → N in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti711S → N in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti711S → N in AAF25577 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25578 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25579 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25580 (Ref. 3) Curated1
Sequence conflicti756M → V in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti837G → R in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti837G → R in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti837G → R in AAF25577 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25578 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25579 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25580 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312431 – 454Missing in isoform S1 and isoform S2. CuratedAdd BLAST454
Alternative sequenceiVSP_031244875 – 923MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform L2 and isoform S2. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF218834 AF218833 Genomic DNA Translation: AAD29628.2
AF218834 AF218833 Genomic DNA Translation: AAF67392.1
AF064236 mRNA Translation: AAF01480.1
AJ010305 mRNA Translation: CAA09076.1
AF132449 Genomic DNA Translation: AAF25577.2
AF132449 Genomic DNA Translation: AAF25578.2
AF132449 Genomic DNA Translation: AAF25579.2
AF132449 Genomic DNA Translation: AAF25580.2
AK030932 mRNA Translation: BAC27188.1
AK170516 mRNA Translation: BAE41853.1
BC010599 mRNA Translation: AAH10599.1
BC066192 mRNA Translation: AAH66192.1
BC069836 mRNA Translation: AAH69836.1
BC069839 mRNA Translation: AAH69839.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24366.1 [Q921U8-2]
CCDS70129.1 [Q921U8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001152756.1, NM_001159284.1 [Q921U8-2]
NP_001271356.1, NM_001284427.1 [Q921U8-1]
NP_001271357.1, NM_001284428.1 [Q921U8-2]
NP_001271358.1, NM_001284429.1
NP_038898.2, NM_013870.3 [Q921U8-2]
XP_017170075.1, XM_017314586.1 [Q921U8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2]
ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1]
ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29856

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:29856

UCSC genome browser

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UCSCi
uc007htf.2, mouse [Q921U8-2]
uc007hti.2, mouse [Q921U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218834 AF218833 Genomic DNA Translation: AAD29628.2
AF218834 AF218833 Genomic DNA Translation: AAF67392.1
AF064236 mRNA Translation: AAF01480.1
AJ010305 mRNA Translation: CAA09076.1
AF132449 Genomic DNA Translation: AAF25577.2
AF132449 Genomic DNA Translation: AAF25578.2
AF132449 Genomic DNA Translation: AAF25579.2
AF132449 Genomic DNA Translation: AAF25580.2
AK030932 mRNA Translation: BAC27188.1
AK170516 mRNA Translation: BAE41853.1
BC010599 mRNA Translation: AAH10599.1
BC066192 mRNA Translation: AAH66192.1
BC069836 mRNA Translation: AAH69836.1
BC069839 mRNA Translation: AAH69839.1
CCDSiCCDS24366.1 [Q921U8-2]
CCDS70129.1 [Q921U8-1]
RefSeqiNP_001152756.1, NM_001159284.1 [Q921U8-2]
NP_001271356.1, NM_001284427.1 [Q921U8-1]
NP_001271357.1, NM_001284428.1 [Q921U8-2]
NP_001271358.1, NM_001284429.1
NP_038898.2, NM_013870.3 [Q921U8-2]
XP_017170075.1, XM_017314586.1 [Q921U8-1]

3D structure databases

SMRiQ921U8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205923, 4 interactors
IntActiQ921U8, 3 interactors
MINTiQ921U8
STRINGi10090.ENSMUSP00000020721

PTM databases

iPTMnetiQ921U8
PhosphoSitePlusiQ921U8

Proteomic databases

PaxDbiQ921U8
PeptideAtlasiQ921U8
PRIDEiQ921U8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3445, 169 antibodies

Genome annotation databases

EnsembliENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2]
ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1]
ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2]
GeneIDi29856
KEGGimmu:29856
UCSCiuc007htf.2, mouse [Q921U8-2]
uc007hti.2, mouse [Q921U8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6525
MGIiMGI:1354727, Smtn

Phylogenomic databases

eggNOGiKOG4678, Eukaryota
GeneTreeiENSGT00940000161655
HOGENOMiCLU_014660_0_0_1
InParanoidiQ921U8
OMAiQNREPTP
OrthoDBi168604at2759
TreeFamiTF316716

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
29856, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Smtn, mouse

Protein Ontology

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PROi
PR:Q921U8
RNActiQ921U8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020439, Expressed in urinary bladder and 208 other tissues
ExpressionAtlasiQ921U8, baseline and differential
GenevisibleiQ921U8, MM

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR022189, SMTN
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12510, Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMTN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q921U8
Secondary accession number(s): Q3TCV2
, Q6NSW1, Q8CD93, Q9JHG8, Q9JLU7, Q9R0D0, Q9R253, Q9Z0Q2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: August 12, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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