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UniProtKB - Q921U8 (SMTN_MOUSE)

Protein

Smoothelin

Gene

Smtn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural protein of the cytoskeleton.By similarity

GO - Molecular functioni

  • actin binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • negative regulation of systemic arterial blood pressure Source: MGI
  • positive regulation of cardiac muscle contraction Source: MGI
View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothelin
Gene namesi
Name:Smtn
Synonyms:Smsmo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1354727 Smtn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003185932 – 923SmoothelinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei359PhosphothreonineBy similarity1
Modified residuei372PhosphothreonineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei641PhosphoserineCombined sources1
Modified residuei735PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Isoform L2 (identifier: Q921U8-2)
Modified residuei372PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ921U8
PeptideAtlasiQ921U8
PRIDEiQ921U8

PTM databases

iPTMnetiQ921U8
PhosphoSitePlusiQ921U8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020439 Expressed in 184 organ(s), highest expression level in urinary bladder
CleanExiMM_SMTN
ExpressionAtlasiQ921U8 baseline and differential
GenevisibleiQ921U8 MM

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi205923, 2 interactors
IntActiQ921U8, 3 interactors
MINTiQ921U8
STRINGi10090.ENSMUSP00000020721

Structurei

3D structure databases

ProteinModelPortaliQ921U8
SMRiQ921U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini805 – 912Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 89Sequence analysisAdd BLAST66
Coiled coili601 – 628Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 272Pro-richAdd BLAST79
Compositional biasi367 – 391Ser-richAdd BLAST25
Compositional biasi645 – 709Thr-richAdd BLAST65
Compositional biasi697 – 740Ser-richAdd BLAST44

Sequence similaritiesi

Belongs to the smoothelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOVERGENiHBG076678
InParanoidiQ921U8
TreeFamiTF316716

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR022189 SMTN
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12510 Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform L1 (identifier: Q921U8-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA 
        60         70         80         90        100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR 
       110        120        130        140        150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA 
       160        170        180        190        200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS 
       210        220        230        240        250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM 
       260        270        280        290        300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL 
       310        320        330        340        350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP 
       360        370        380        390        400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH 
       410        420        430        440        450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE 
       460        470        480        490        500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS 
       510        520        530        540        550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP 
       560        570        580        590        600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF 
       610        620        630        640        650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR 
       660        670        680        690        700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS 
       710        720        730        740        750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE 
       760        770        780        790        800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG 
       810        820        830        840        850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE 
       860        870        880        890        900
AFDYGQLSPQ NRRQNFEMAF SSAEMLVDCV PLVEVEDMMI MGKKPDPKCV 
       910        920 
FTYVQSLYNH LRRHELRLRG KNV
Length:923
Mass (Da):100,289
Last modified:February 5, 2008 - v2
Checksum:i2E70E413C8B487C7
GO
Isoform L2 (identifier: Q921U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:921
Mass (Da):100,135
Checksum:i019B4D29FC07BACF
GO
Isoform S1 (identifier: Q921U8-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.

Show »
Length:469
Mass (Da):51,657
Checksum:i7DB57BDE4A611CA1
GO
Isoform S2 (identifier: Q921U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:467
Mass (Da):51,503
Checksum:iCE56CFFC6761D5A4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3Q3D3Z3Q3_MOUSE
Smoothelin
Smtn
946Annotation score:
D3YVS1D3YVS1_MOUSE
Smoothelin
Smtn
436Annotation score:
D3Z525D3Z525_MOUSE
Smoothelin
Smtn
122Annotation score:
D3YZ10D3YZ10_MOUSE
Smoothelin
Smtn
140Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173P → S in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti173P → S in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti173P → S in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti173P → S in AAF25577 (Ref. 3) Curated1
Sequence conflicti173P → S in AAF25578 (Ref. 3) Curated1
Sequence conflicti379Missing in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti441P → Q in BAE41853 (PubMed:16141072).Curated1
Sequence conflicti448T → N in BAC27188 (PubMed:16141072).Curated1
Sequence conflicti450E → G in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti711S → N in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti711S → N in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti711S → N in AAF25577 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25578 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25579 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25580 (Ref. 3) Curated1
Sequence conflicti756M → V in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti837G → R in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti837G → R in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti837G → R in AAF25577 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25578 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25579 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25580 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312431 – 454Missing in isoform S1 and isoform S2. CuratedAdd BLAST454
Alternative sequenceiVSP_031244875 – 923MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform L2 and isoform S2. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218834
, AF116517, AF116518, AF195524, AF195525, AF218829, AF218830, AF218831, AF218832, AF218833 Genomic DNA Translation: AAD29628.2
AF218834
, AF116518, AF195525, AF218830, AF218831, AF218832, AF218833 Genomic DNA Translation: AAF67392.1
AF064236 mRNA Translation: AAF01480.1
AJ010305 mRNA Translation: CAA09076.1
AF132449 Genomic DNA Translation: AAF25577.2
AF132449 Genomic DNA Translation: AAF25578.2
AF132449 Genomic DNA Translation: AAF25579.2
AF132449 Genomic DNA Translation: AAF25580.2
AK030932 mRNA Translation: BAC27188.1
AK170516 mRNA Translation: BAE41853.1
BC010599 mRNA Translation: AAH10599.1
BC066192 mRNA Translation: AAH66192.1
BC069836 mRNA Translation: AAH69836.1
BC069839 mRNA Translation: AAH69839.1
CCDSiCCDS24366.1 [Q921U8-2]
CCDS70129.1 [Q921U8-1]
RefSeqiNP_001152756.1, NM_001159284.1 [Q921U8-2]
NP_001271356.1, NM_001284427.1 [Q921U8-1]
NP_001271357.1, NM_001284428.1 [Q921U8-2]
NP_001271358.1, NM_001284429.1
NP_038898.2, NM_013870.3 [Q921U8-2]
XP_017170075.1, XM_017314586.1 [Q921U8-1]
UniGeneiMm.188516

Genome annotation databases

EnsembliENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2]
ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1]
ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2]
GeneIDi29856
KEGGimmu:29856
UCSCiuc007htf.2 mouse [Q921U8-2]
uc007hti.2 mouse [Q921U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218834
, AF116517, AF116518, AF195524, AF195525, AF218829, AF218830, AF218831, AF218832, AF218833 Genomic DNA Translation: AAD29628.2
AF218834
, AF116518, AF195525, AF218830, AF218831, AF218832, AF218833 Genomic DNA Translation: AAF67392.1
AF064236 mRNA Translation: AAF01480.1
AJ010305 mRNA Translation: CAA09076.1
AF132449 Genomic DNA Translation: AAF25577.2
AF132449 Genomic DNA Translation: AAF25578.2
AF132449 Genomic DNA Translation: AAF25579.2
AF132449 Genomic DNA Translation: AAF25580.2
AK030932 mRNA Translation: BAC27188.1
AK170516 mRNA Translation: BAE41853.1
BC010599 mRNA Translation: AAH10599.1
BC066192 mRNA Translation: AAH66192.1
BC069836 mRNA Translation: AAH69836.1
BC069839 mRNA Translation: AAH69839.1
CCDSiCCDS24366.1 [Q921U8-2]
CCDS70129.1 [Q921U8-1]
RefSeqiNP_001152756.1, NM_001159284.1 [Q921U8-2]
NP_001271356.1, NM_001284427.1 [Q921U8-1]
NP_001271357.1, NM_001284428.1 [Q921U8-2]
NP_001271358.1, NM_001284429.1
NP_038898.2, NM_013870.3 [Q921U8-2]
XP_017170075.1, XM_017314586.1 [Q921U8-1]
UniGeneiMm.188516

3D structure databases

ProteinModelPortaliQ921U8
SMRiQ921U8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205923, 2 interactors
IntActiQ921U8, 3 interactors
MINTiQ921U8
STRINGi10090.ENSMUSP00000020721

PTM databases

iPTMnetiQ921U8
PhosphoSitePlusiQ921U8

Proteomic databases

PaxDbiQ921U8
PeptideAtlasiQ921U8
PRIDEiQ921U8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2]
ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1]
ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2]
GeneIDi29856
KEGGimmu:29856
UCSCiuc007htf.2 mouse [Q921U8-2]
uc007hti.2 mouse [Q921U8-1]

Organism-specific databases

CTDi6525
MGIiMGI:1354727 Smtn

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOVERGENiHBG076678
InParanoidiQ921U8
TreeFamiTF316716

Miscellaneous databases

ChiTaRSiSmtn mouse
PROiPR:Q921U8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020439 Expressed in 184 organ(s), highest expression level in urinary bladder
CleanExiMM_SMTN
ExpressionAtlasiQ921U8 baseline and differential
GenevisibleiQ921U8 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR022189 SMTN
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12510 Smoothelin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMTN_MOUSE
AccessioniPrimary (citable) accession number: Q921U8
Secondary accession number(s): Q3TCV2
, Q6NSW1, Q8CD93, Q9JHG8, Q9JLU7, Q9R0D0, Q9R253, Q9Z0Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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