UniProtKB - Q921U8 (SMTN_MOUSE)
Smoothelin
Smtn
Functioni
GO - Molecular functioni
- actin binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- negative regulation of systemic arterial blood pressure Source: MGI
- positive regulation of cardiac muscle contraction Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Smoothelin |
Gene namesi | Name:Smtn Synonyms:Smsmo |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1354727, Smtn |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Note: Exhibits a filamentous organization.By similarity
Cytoskeleton
- filamentous actin Source: GO_Central
- microtubule organizing center Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000318593 | 2 – 923 | SmoothelinAdd BLAST | 922 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | ||
Modified residuei | 299 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 301 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 304 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 340 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 359 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 372 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 501 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 521 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 574 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 641 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 735 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 798 | PhosphoserineBy similarity | 1 | ||
Isoform L2 (identifier: Q921U8-2) | |||||
Modified residuei | 372 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q921U8 |
PeptideAtlasi | Q921U8 |
PRIDEi | Q921U8 |
PTM databases
iPTMneti | Q921U8 |
PhosphoSitePlusi | Q921U8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020439, Expressed in urinary bladder and 208 other tissues |
ExpressionAtlasi | Q921U8, baseline and differential |
Genevisiblei | Q921U8, MM |
Interactioni
GO - Molecular functioni
- actin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 205923, 4 interactors |
IntActi | Q921U8, 3 interactors |
MINTi | Q921U8 |
STRINGi | 10090.ENSMUSP00000020721 |
Miscellaneous databases
RNActi | Q921U8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 805 – 912 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 108 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 24 – 89 | Sequence analysisAdd BLAST | 66 | |
Coiled coili | 601 – 628 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 272 | Pro-richAdd BLAST | 79 | |
Compositional biasi | 367 – 391 | Ser-richAdd BLAST | 25 | |
Compositional biasi | 645 – 709 | Thr-richAdd BLAST | 65 | |
Compositional biasi | 697 – 740 | Ser-richAdd BLAST | 44 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4678, Eukaryota |
GeneTreei | ENSGT00940000161655 |
HOGENOMi | CLU_014660_0_0_1 |
InParanoidi | Q921U8 |
OMAi | QNREPTP |
OrthoDBi | 168604at2759 |
TreeFami | TF316716 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR022189, SMTN |
Pfami | View protein in Pfam PF00307, CH, 1 hit PF12510, Smoothelin, 3 hits |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA
60 70 80 90 100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR
110 120 130 140 150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA
160 170 180 190 200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS
210 220 230 240 250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM
260 270 280 290 300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL
310 320 330 340 350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP
360 370 380 390 400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH
410 420 430 440 450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE
460 470 480 490 500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS
510 520 530 540 550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP
560 570 580 590 600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF
610 620 630 640 650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR
660 670 680 690 700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS
710 720 730 740 750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE
760 770 780 790 800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG
810 820 830 840 850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE
860 870 880 890 900
AFDYGQLSPQ NRRQNFEMAF SSAEMLVDCV PLVEVEDMMI MGKKPDPKCV
910 920
FTYVQSLYNH LRRHELRLRG KNV
The sequence of this isoform differs from the canonical sequence as follows:
875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS
The sequence of this isoform differs from the canonical sequence as follows:
1-454: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-454: Missing.
875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YVS1 | D3YVS1_MOUSE | Smoothelin | Smtn | 436 | Annotation score: | ||
D3Z3Q3 | D3Z3Q3_MOUSE | Smoothelin | Smtn | 946 | Annotation score: | ||
D3YZ10 | D3YZ10_MOUSE | Smoothelin | Smtn | 140 | Annotation score: | ||
D3Z525 | D3Z525_MOUSE | Smoothelin | Smtn | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | P → S in AAD29628 (PubMed:10965129).Curated | 1 | |
Sequence conflicti | 173 | P → S in AAF01480 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 173 | P → S in CAA09076 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 173 | P → S in AAF25577 (Ref. 3) Curated | 1 | |
Sequence conflicti | 173 | P → S in AAF25578 (Ref. 3) Curated | 1 | |
Sequence conflicti | 379 | Missing in AAH69839 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 379 | Missing in AAH69836 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 379 | Missing in AAH66192 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 441 | P → Q in BAE41853 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 448 | T → N in BAC27188 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 450 | E → G in AAH69839 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 450 | E → G in AAH69836 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 450 | E → G in AAH66192 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 711 | S → N in AAD29628 (PubMed:10965129).Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF67392 (PubMed:10965129).Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF01480 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 711 | S → N in CAA09076 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF25577 (Ref. 3) Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF25578 (Ref. 3) Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF25579 (Ref. 3) Curated | 1 | |
Sequence conflicti | 711 | S → N in AAF25580 (Ref. 3) Curated | 1 | |
Sequence conflicti | 756 | M → V in AAH69839 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 756 | M → V in AAH69836 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 756 | M → V in AAH66192 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 837 | G → R in AAD29628 (PubMed:10965129).Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF67392 (PubMed:10965129).Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF01480 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 837 | G → R in CAA09076 (PubMed:10023782).Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF25577 (Ref. 3) Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF25578 (Ref. 3) Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF25579 (Ref. 3) Curated | 1 | |
Sequence conflicti | 837 | G → R in AAF25580 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031243 | 1 – 454 | Missing in isoform S1 and isoform S2. CuratedAdd BLAST | 454 | |
Alternative sequenceiVSP_031244 | 875 – 923 | MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform L2 and isoform S2. 3 PublicationsAdd BLAST | 49 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2] ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1] ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2] |
GeneIDi | 29856 |
KEGGi | mmu:29856 |
UCSCi | uc007htf.2, mouse [Q921U8-2] uc007hti.2, mouse [Q921U8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | Q921U8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205923, 4 interactors |
IntActi | Q921U8, 3 interactors |
MINTi | Q921U8 |
STRINGi | 10090.ENSMUSP00000020721 |
PTM databases
iPTMneti | Q921U8 |
PhosphoSitePlusi | Q921U8 |
Proteomic databases
PaxDbi | Q921U8 |
PeptideAtlasi | Q921U8 |
PRIDEi | Q921U8 |
Protocols and materials databases
Antibodypediai | 3445, 169 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439 [Q921U8-2] ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439 [Q921U8-1] ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439 [Q921U8-2] |
GeneIDi | 29856 |
KEGGi | mmu:29856 |
UCSCi | uc007htf.2, mouse [Q921U8-2] uc007hti.2, mouse [Q921U8-1] |
Organism-specific databases
CTDi | 6525 |
MGIi | MGI:1354727, Smtn |
Phylogenomic databases
eggNOGi | KOG4678, Eukaryota |
GeneTreei | ENSGT00940000161655 |
HOGENOMi | CLU_014660_0_0_1 |
InParanoidi | Q921U8 |
OMAi | QNREPTP |
OrthoDBi | 168604at2759 |
TreeFami | TF316716 |
Miscellaneous databases
BioGRID-ORCSi | 29856, 2 hits in 17 CRISPR screens |
ChiTaRSi | Smtn, mouse |
PROi | PR:Q921U8 |
RNActi | Q921U8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020439, Expressed in urinary bladder and 208 other tissues |
ExpressionAtlasi | Q921U8, baseline and differential |
Genevisiblei | Q921U8, MM |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR001715, CH-domain IPR036872, CH_dom_sf IPR022189, SMTN |
Pfami | View protein in Pfam PF00307, CH, 1 hit PF12510, Smoothelin, 3 hits |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS50021, CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMTN_MOUSE | |
Accessioni | Q921U8Primary (citable) accession number: Q921U8 Secondary accession number(s): Q3TCV2 Q9Z0Q2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families