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UniProtKB - Q921T2 (TOIP1_MOUSE)

Protein

Torsin-1A-interacting protein 1

Gene

Tor1aip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • nuclear membrane organization Source: MGI
  • positive regulation of ATPase activity Source: UniProtKB
  • protein localization to nucleus Source: MGI
View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Torsin-1A-interacting protein 1
Alternative name(s):
Lamina-associated polypeptide 1B
Short name:
LAP1B
Gene namesi
Name:Tor1aip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3582693 Tor1aip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 351NuclearSequence analysisAdd BLAST351
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 595Perinuclear spaceSequence analysisAdd BLAST223

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant mice exhibit perinatal mortality, typically dying on the last prenatal or first postnatal day. All tissues tested exhibit nuclear membrane abnormalities with membranous vesicle-appearing structures observed in the perinuclear space of neurons.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002288361 – 595Torsin-1A-interacting protein 1Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei134PhosphoserineBy similarity1
Modified residuei140PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei153PhosphoserineBy similarity1
Modified residuei154PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei235PhosphothreonineBy similarity1
Modified residuei241PhosphoserineBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Cross-linki321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei328PhosphoserineBy similarity1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ921T2
PeptideAtlasiQ921T2
PRIDEiQ921T2

PTM databases

iPTMnetiQ921T2
PhosphoSitePlusiQ921T2
SwissPalmiQ921T2

Expressioni

Tissue specificityi

Expressed in the spinal cord and liver (at protein level).1 Publication

Developmental stagei

At E16, widely expressed with high expression levels in hippocampus and low levels in heart. In the spinal cord, expressed as early as E12 until p21, the expression levels decrease in the adulthood (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000026466 Expressed in 266 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_TOR1AIP1
ExpressionAtlasiQ921T2 baseline and differential
GenevisibleiQ921T2 MM

Interactioni

Subunit structurei

Interacts with ATP1B4. Interacts with TOR1A (ATP-bound). Interacts with TOR1B, TOR2A and TOR3A. Interacts with VIM.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi228970, 36 interactors
DIPiDIP-56693N
IntActiQ921T2, 36 interactors
MINTiQ921T2
STRINGi10090.ENSMUSP00000095134

Structurei

3D structure databases

ProteinModelPortaliQ921T2
SMRiQ921T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni368 – 595Interaction with TOR1ABy similarityAdd BLAST228

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili373 – 400Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 129Arg-richAdd BLAST108

Sequence similaritiesi

Belongs to the TOR1AIP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUB Eukaryota
ENOG4111IZJ LUCA
GeneTreeiENSGT00390000012166
HOGENOMiHOG000015293
HOVERGENiHBG083152
InParanoidiQ921T2
OMAiWQSSQSR
OrthoDBiEOG091G05ZP
TreeFamiTF329438

Family and domain databases

Gene3Di3.40.50.12190, 1 hit
InterProiView protein in InterPro
IPR008662 Lamina-ass_polypeptide_CLAP1C
IPR038599 LAP1C-like_C_sf
PANTHERiPTHR18843 PTHR18843, 1 hit
PfamiView protein in Pfam
PF05609 LAP1C, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q921T2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGERWQAEG PGEGWAIYVT PRAPIREGRR RLDPRNGDSS DAPAYGAHPS 
        60         70         80         90        100
RRGRREVRFS EEPAEVYGDF EPRAAKERSP GGRRTPPEKF RPASAGEEVR 
       110        120        130        140        150
ESAYNLRSRP RRQRRAQEAE EMKTRRSARL EQHSQQPQLS PATSGRGLRD 
       160        170        180        190        200
SPSSSEDREE DEPSSRPVTS QTASKKTLRT PEASVMNEDP ISNLCRPPLR 
       210        220        230        240        250
SPRLDSTYQT NGNTKTNERE ATIVQQVNFF EEGETEDDLE SSYSDITIRA 
       260        270        280        290        300
RSSDSLESRD EATPAAGNHP DSLRGLPHNQ DFPAHENQPL LLTSGCQENP 
       310        320        330        340        350
QEWVDRAVRM RSRMAYNNIQ KSNFGNQSPS TSRPQSAIHH PNEPSVKIKW 
       360        370        380        390        400
WLLGLVAILA VGLFWFFHTP AVETTAVQEF QNQMKQLQSK YQSQNEKLWK 
       410        420        430        440        450
RGTTFLEKHL NSSLPRPQPA ILLLTAAQDA AEVLKCLSEQ IADAYSSFRS 
       460        470        480        490        500
VRAIRIDGAG KAAQDSDLVK HEVDQELTDG FKNGQNAAVV HRFESLPAGS 
       510        520        530        540        550
TLIFYKYCDH ENAAFKDVAL VLTVLLEEKT LEASLGLKEI EEKVRDFLKV 
       560        570        580        590 
KFTSSSTASS YNHMDPDKLN GLWSRISHLV LPVQPENTLK AGSCL
Length:595
Mass (Da):66,781
Last modified:April 18, 2012 - v3
Checksum:i8456CF717594ED53
GO
Isoform 2 (identifier: Q921T2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     261-279: Missing.

Show »
Length:576
Mass (Da):64,845
Checksum:iEBB638C2B681D547
GO
Isoform 3 (identifier: Q921T2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-335: DEATPAAGNH...NQSPSTSRPQ → E

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):58,416
Checksum:i9BCAA96171EF0E5F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWW2E9PWW2_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
391Annotation score:
D3YZJ9D3YZJ9_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
190Annotation score:
D3YZP0D3YZP0_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
176Annotation score:
J3QQ40J3QQ40_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
291Annotation score:
Q3UE61Q3UE61_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
324Annotation score:
D3YXF8D3YXF8_MOUSE
Torsin-1A-interacting protein 1
Tor1aip1
102Annotation score:

Sequence cautioni

The sequence BAE31466 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108S → A in BAE31466 (PubMed:16141072).Curated1
Sequence conflicti254D → N in BAE94915 (Ref. 1) Curated1
Sequence conflicti254D → N in AAH10841 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042952260 – 335DEATP…TSRPQ → E in isoform 3. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_042953261 – 279Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB251963 mRNA Translation: BAE94915.1
AC159964 Genomic DNA No translation available.
BC010841 mRNA Translation: AAH10841.1
AK152751 mRNA Translation: BAE31466.1 Different initiation.
CCDSiCCDS15387.1 [Q921T2-3]
CCDS48402.1 [Q921T2-2]
RefSeqiNP_001153490.1, NM_001160018.1 [Q921T2-2]
NP_001153491.1, NM_001160019.1
NP_659040.2, NM_144791.2 [Q921T2-3]
UniGeneiMm.211654

Genome annotation databases

EnsembliENSMUST00000027738; ENSMUSP00000027738; ENSMUSG00000026466 [Q921T2-3]
ENSMUST00000097527; ENSMUSP00000095134; ENSMUSG00000026466 [Q921T2-2]
GeneIDi208263
KEGGimmu:208263
UCSCiuc007dbu.2 mouse [Q921T2-3]
uc007dbw.2 mouse [Q921T2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB251963 mRNA Translation: BAE94915.1
AC159964 Genomic DNA No translation available.
BC010841 mRNA Translation: AAH10841.1
AK152751 mRNA Translation: BAE31466.1 Different initiation.
CCDSiCCDS15387.1 [Q921T2-3]
CCDS48402.1 [Q921T2-2]
RefSeqiNP_001153490.1, NM_001160018.1 [Q921T2-2]
NP_001153491.1, NM_001160019.1
NP_659040.2, NM_144791.2 [Q921T2-3]
UniGeneiMm.211654

3D structure databases

ProteinModelPortaliQ921T2
SMRiQ921T2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228970, 36 interactors
DIPiDIP-56693N
IntActiQ921T2, 36 interactors
MINTiQ921T2
STRINGi10090.ENSMUSP00000095134

PTM databases

iPTMnetiQ921T2
PhosphoSitePlusiQ921T2
SwissPalmiQ921T2

Proteomic databases

PaxDbiQ921T2
PeptideAtlasiQ921T2
PRIDEiQ921T2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027738; ENSMUSP00000027738; ENSMUSG00000026466 [Q921T2-3]
ENSMUST00000097527; ENSMUSP00000095134; ENSMUSG00000026466 [Q921T2-2]
GeneIDi208263
KEGGimmu:208263
UCSCiuc007dbu.2 mouse [Q921T2-3]
uc007dbw.2 mouse [Q921T2-2]

Organism-specific databases

CTDi26092
MGIiMGI:3582693 Tor1aip1

Phylogenomic databases

eggNOGiENOG410IJUB Eukaryota
ENOG4111IZJ LUCA
GeneTreeiENSGT00390000012166
HOGENOMiHOG000015293
HOVERGENiHBG083152
InParanoidiQ921T2
OMAiWQSSQSR
OrthoDBiEOG091G05ZP
TreeFamiTF329438

Miscellaneous databases

PROiPR:Q921T2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026466 Expressed in 266 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_TOR1AIP1
ExpressionAtlasiQ921T2 baseline and differential
GenevisibleiQ921T2 MM

Family and domain databases

Gene3Di3.40.50.12190, 1 hit
InterProiView protein in InterPro
IPR008662 Lamina-ass_polypeptide_CLAP1C
IPR038599 LAP1C-like_C_sf
PANTHERiPTHR18843 PTHR18843, 1 hit
PfamiView protein in Pfam
PF05609 LAP1C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOIP1_MOUSE
AccessioniPrimary (citable) accession number: Q921T2
Secondary accession number(s): E9QLK1, Q1EQW1, Q3U7A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: April 18, 2012
Last modified: November 7, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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