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Protein

Solute carrier family 41 member 3

Gene

Slc41a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 3
Gene namesi
Name:Slc41a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918949 Slc41a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002955931 – 488Solute carrier family 41 member 3Add BLAST488

Proteomic databases

PaxDbiQ921R8
PeptideAtlasiQ921R8
PRIDEiQ921R8

PTM databases

PhosphoSitePlusiQ921R8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030089 Expressed in 261 organ(s), highest expression level in interventricular septum
CleanExiMM_SLC41A3
ExpressionAtlasiQ921R8 baseline and differential
GenevisibleiQ921R8 MM

Interactioni

Protein-protein interaction databases

IntActiQ921R8, 1 interactor
MINTiQ921R8
STRINGi10090.ENSMUSP00000037473

Structurei

3D structure databases

ProteinModelPortaliQ921R8
SMRiQ921R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3788 Eukaryota
ENOG410XSTG LUCA
GeneTreeiENSGT00390000016816
HOGENOMiHOG000007017
HOVERGENiHBG057187
InParanoidiQ921R8
KOiK15122
OMAiTQLNLEF
PhylomeDBiQ921R8

Family and domain databases

InterProiView protein in InterPro
IPR006667 SLC41_membr_dom
IPR036739 SLC41_membr_dom_sf
PfamiView protein in Pfam
PF01769 MgtE, 2 hits
SUPFAMiSSF161093 SSF161093, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q921R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGTEARQRR LEGCGRLKEL GPLPSHDAGR LPKASEEGHL AVSESQLVDA
60 70 80 90 100
KSLEAPPGRE TSLIIGFQVV IPFLLAGVGL SWAGLLLNYF QHWPVFKDVK
110 120 130 140 150
DLMTLVPPLV GLKGNLEMTL ASRLSTSANT GQIDDRQERY KIISSNLAVV
160 170 180 190 200
QVQATVVGLL AAVASLMLGT VSHEEFDWSK VALLCTSSVI TAFLAALALG
210 220 230 240 250
ILMICIVIGA RKFGVNPDNI ATPIAASLGD LITLSILALM SSFFYSHKDT
260 270 280 290 300
WYLTPLVCVG FLALTPLWLF IAKQNPPIMK ILKYGWFPII LAMIISSFGG
310 320 330 340 350
LILSKTISKH EFKGMAVLTP VMCGVGGNLV AIQTSRISTF LHMWSTPGVL
360 370 380 390 400
PVQMKRFWPN PCFIFCSSEI NSVSARVLLF LVVPGHLIFF YLICLVEGQS
410 420 430 440 450
VTNSKIFILL YLVAGVVQVV ILLYLAEVTV RLTWHQALDP DNHCIPYLTG
460 470 480
LGDLLGTSLL ALCFFLDWLL RGRANLQELV SELVSVPP
Length:488
Mass (Da):53,257
Last modified:December 1, 2001 - v1
Checksum:iE43401605DC1EEC0
GO
Isoform 2 (identifier: Q921R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MEGTEARQRR...SWAGLLLNYF → MVVTQLSLEF...MTAGLVMNTV

Show »
Length:462
Mass (Da):50,537
Checksum:i078F8221C77F0875
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X937G3X937_MOUSE
Solute carrier family 41 member 3
Slc41a3 mCG_128603
488Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0269391 – 90MEGTE…LLNYF → MVVTQLSLEFRFQGKKLRGF SCELTRSPHGILPEPVLTTT CQVAIPILLSGLGMMTAGLV MNTV in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003140 mRNA Translation: BAB22598.1
BC011108 mRNA Translation: AAH11108.1
CCDSiCCDS20362.1 [Q921R8-1]
CCDS20363.1 [Q921R8-2]
RefSeqiNP_001032570.1, NM_001037493.2 [Q921R8-2]
NP_082144.2, NM_027868.2
UniGeneiMm.272633

Genome annotation databases

EnsembliENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089 [Q921R8-2]
GeneIDi71699
KEGGimmu:71699
UCSCiuc009cxp.2 mouse [Q921R8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003140 mRNA Translation: BAB22598.1
BC011108 mRNA Translation: AAH11108.1
CCDSiCCDS20362.1 [Q921R8-1]
CCDS20363.1 [Q921R8-2]
RefSeqiNP_001032570.1, NM_001037493.2 [Q921R8-2]
NP_082144.2, NM_027868.2
UniGeneiMm.272633

3D structure databases

ProteinModelPortaliQ921R8
SMRiQ921R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ921R8, 1 interactor
MINTiQ921R8
STRINGi10090.ENSMUSP00000037473

PTM databases

PhosphoSitePlusiQ921R8

Proteomic databases

PaxDbiQ921R8
PeptideAtlasiQ921R8
PRIDEiQ921R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089 [Q921R8-2]
GeneIDi71699
KEGGimmu:71699
UCSCiuc009cxp.2 mouse [Q921R8-2]

Organism-specific databases

CTDi54946
MGIiMGI:1918949 Slc41a3

Phylogenomic databases

eggNOGiKOG3788 Eukaryota
ENOG410XSTG LUCA
GeneTreeiENSGT00390000016816
HOGENOMiHOG000007017
HOVERGENiHBG057187
InParanoidiQ921R8
KOiK15122
OMAiTQLNLEF
PhylomeDBiQ921R8

Miscellaneous databases

PROiPR:Q921R8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030089 Expressed in 261 organ(s), highest expression level in interventricular septum
CleanExiMM_SLC41A3
ExpressionAtlasiQ921R8 baseline and differential
GenevisibleiQ921R8 MM

Family and domain databases

InterProiView protein in InterPro
IPR006667 SLC41_membr_dom
IPR036739 SLC41_membr_dom_sf
PfamiView protein in Pfam
PF01769 MgtE, 2 hits
SUPFAMiSSF161093 SSF161093, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS41A3_MOUSE
AccessioniPrimary (citable) accession number: Q921R8
Secondary accession number(s): Q9DC67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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