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Protein

DnaJ homolog subfamily C member 14

Gene

Dnajc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Gene namesi
Name:Dnajc14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1921580 Dnajc14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474941 – 703DnaJ homolog subfamily C member 14Add BLAST703

Proteomic databases

MaxQBiQ921R4
PaxDbiQ921R4
PRIDEiQ921R4

PTM databases

iPTMnetiQ921R4
PhosphoSitePlusiQ921R4

Expressioni

Gene expression databases

BgeeiENSMUSG00000025354 Expressed in 276 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNAJC14
ExpressionAtlasiQ921R4 baseline and differential
GenevisibleiQ921R4 MM

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026410

Structurei

3D structure databases

ProteinModelPortaliQ921R4
SMRiQ921R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini444 – 508JPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi149 – 152Poly-Ser4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0720 Eukaryota
ENOG410Z2TP LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000290199
HOVERGENiHBG059561
InParanoidiQ921R4
KOiK09534
OMAiFRVWVGV
OrthoDBiEOG091G038N
PhylomeDBiQ921R4
TreeFamiTF105173

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q921R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKHPGERR LCGAHRSGGT SLSTSGSSVD PEILSFSGLR DSAETAPNGT
60 70 80 90 100
RCLKEHSGPK YTQPPNPAHW SDPSHGPPRG PGPPRGGGYP DESETGSEES
110 120 130 140 150
GVDQELSREN ETGYQEDGSP SFLSIPSACN CQGSPGVPEG TYSEEGDGSS
160 170 180 190 200
SSLCHHCTSP ALGEDEELEE EYDDEEPLKF PSDFSRVSSG KKPLSRRQKH
210 220 230 240 250
RFLIKEDVRD SGRREPKAPG RHRLARKRSQ TDKRRGLGLW GVEELCQLGQ
260 270 280 290 300
AGFWWLIELL VLVGEYVETC GHLIYACRKL KGSDLDLFRV WVGVWARRLG
310 320 330 340 350
GWARMMFQFL SQSFFCVVGL LIRILRVVGA FLLLALALFL GCLQLGWRFS
360 370 380 390 400
VGLGNRLGWR DKTAWLFSWL GSPALHHCLT LLKDSRPWQQ LVRLIQWGWQ
410 420 430 440 450
ELPWVKQRTK KQGNAPVASG RYCQPEEEVT RLLTMAGVPE DELNPFHVLG
460 470 480 490 500
VEATASDTEL KKAYRQLAVM VHPDKNHHPR AEEAFKILRA AWDIVSNPER
510 520 530 540 550
RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR CQGKHRRFEM
560 570 580 590 600
DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE
610 620 630 640 650
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR
660 670 680 690 700
IFQVPPGPMS NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP

FQR
Length:703
Mass (Da):78,919
Last modified:July 25, 2006 - v2
Checksum:iB320DB4FB06345FE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P767A0A1W2P767_MOUSE
DnaJ homolog subfamily C member 14
Dnajc14
184Annotation score:
A0A1W2P6T2A0A1W2P6T2_MOUSE
DnaJ homolog subfamily C member 14
Dnajc14
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268E → K in BAE35043 (PubMed:16141072).Curated1
Sequence conflicti558R → G in BAC38536 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti203L → P in strain: Czech II. 1 Publication1
Natural varianti642A → V in strain: Czech II. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017830 mRNA Translation: BAB30962.1
AK045445 mRNA Translation: BAC32372.1
AK082579 mRNA Translation: BAC38536.1
AK159388 mRNA Translation: BAE35043.1
BC011146 mRNA Translation: AAH11146.1
CCDSiCCDS24294.1
RefSeqiNP_083149.3, NM_028873.4
XP_006514312.1, XM_006514249.3
XP_006514313.1, XM_006514250.2
XP_006514314.1, XM_006514251.1
UniGeneiMm.296915

Genome annotation databases

EnsembliENSMUST00000026410; ENSMUSP00000026410; ENSMUSG00000025354
ENSMUST00000217745; ENSMUSP00000151530; ENSMUSG00000025354
ENSMUST00000219508; ENSMUSP00000151343; ENSMUSG00000025354
GeneIDi74330
KEGGimmu:74330
UCSCiuc007hok.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017830 mRNA Translation: BAB30962.1
AK045445 mRNA Translation: BAC32372.1
AK082579 mRNA Translation: BAC38536.1
AK159388 mRNA Translation: BAE35043.1
BC011146 mRNA Translation: AAH11146.1
CCDSiCCDS24294.1
RefSeqiNP_083149.3, NM_028873.4
XP_006514312.1, XM_006514249.3
XP_006514313.1, XM_006514250.2
XP_006514314.1, XM_006514251.1
UniGeneiMm.296915

3D structure databases

ProteinModelPortaliQ921R4
SMRiQ921R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026410

PTM databases

iPTMnetiQ921R4
PhosphoSitePlusiQ921R4

Proteomic databases

MaxQBiQ921R4
PaxDbiQ921R4
PRIDEiQ921R4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026410; ENSMUSP00000026410; ENSMUSG00000025354
ENSMUST00000217745; ENSMUSP00000151530; ENSMUSG00000025354
ENSMUST00000219508; ENSMUSP00000151343; ENSMUSG00000025354
GeneIDi74330
KEGGimmu:74330
UCSCiuc007hok.1 mouse

Organism-specific databases

CTDi85406
MGIiMGI:1921580 Dnajc14

Phylogenomic databases

eggNOGiKOG0720 Eukaryota
ENOG410Z2TP LUCA
GeneTreeiENSGT00930000150905
HOGENOMiHOG000290199
HOVERGENiHBG059561
InParanoidiQ921R4
KOiK09534
OMAiFRVWVGV
OrthoDBiEOG091G038N
PhylomeDBiQ921R4
TreeFamiTF105173

Miscellaneous databases

PROiPR:Q921R4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025354 Expressed in 276 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNAJC14
ExpressionAtlasiQ921R4 baseline and differential
GenevisibleiQ921R4 MM

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR032843 Jiv
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF14901 Jiv90, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC14_MOUSE
AccessioniPrimary (citable) accession number: Q921R4
Secondary accession number(s): Q3TX73, Q8BUU3, Q9CYB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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