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Protein

Ras and Rab interactor 1

Gene

Rin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity).By similarity1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB-KW
  • Ras GTPase binding Source: MGI

GO - Biological processi

  • associative learning Source: MGI
  • endocytosis Source: UniProtKB-KW
  • memory Source: MGI
  • negative regulation of synaptic plasticity Source: MGI
  • signal transduction Source: InterPro

Keywordsi

Molecular functionGTPase activation
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras and Rab interactor 1
Alternative name(s):
Ras interaction/interference protein 1
Gene namesi
Name:Rin1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2385695 Rin1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913181 – 763Ras and Rab interactor 1Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei35Phosphotyrosine; by ABL1 and ABL2Combined sources1
Modified residuei198PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei323PhosphoserineBy similarity1
Modified residuei340Phosphoserine; by PKD/PRKD1By similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei681Omega-N-methylarginineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-340 by PRKD1 induces interaction with 14-3-3 proteins (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ921Q7
PaxDbiQ921Q7
PeptideAtlasiQ921Q7
PRIDEiQ921Q7

PTM databases

iPTMnetiQ921Q7
PhosphoSitePlusiQ921Q7
SwissPalmiQ921Q7

Expressioni

Tissue specificityi

Highly expressed in brain. Weakly or no expressed in other tissues, except in testis, where it is expressed at intermediate level. In brain, it is mainly expressed in postnatal forebrain neurons in which it is localized in dendrites and colocalizes with Ras.1 Publication

Gene expression databases

BgeeiENSMUSG00000024883 Expressed in 210 organ(s), highest expression level in nucleus accumbens
CleanExiMM_RIN1
ExpressionAtlasiQ921Q7 baseline and differential
GenevisibleiQ921Q7 MM

Interactioni

Subunit structurei

Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-340. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-340 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Epha4Q031372EBI-15724937,EBI-1539152

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230435, 5 interactors
DIPiDIP-46280N
IntActiQ921Q7, 1 interactor
STRINGi10090.ENSMUSP00000025818

Structurei

3D structure databases

ProteinModelPortaliQ921Q7
SMRiQ921Q7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 151SH2Add BLAST84
Domaini445 – 587VPS9PROSITE-ProRule annotationAdd BLAST143
Domaini613 – 695Ras-associatingPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 256Pro-rich10
Compositional biasi402 – 601Leu-richAdd BLAST200

Sequence similaritiesi

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOGENOMiHOG000154128
HOVERGENiHBG036105
InParanoidiQ921Q7
KOiK17638
OrthoDBiEOG091G02V2
PhylomeDBiQ921Q7
TreeFamiTF331067

Family and domain databases

CDDicd10393 SH2_RIN1, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035867 RIN1_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS51205 VPS9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q921Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPGETGAH PLGATNLNFV PGHQQKEKPS TDPLYDTPDT RGVQAGGSQQ
60 70 80 90 100
PARTVSLRER LLITRPVWLQ LRANAAAALH VLRTEPPGTF LVRKSNTRQC
110 120 130 140 150
QALCVRLPEA SGPSFVSSHY IEESTGGVSL EGSELMFQDL VQLICGYCRT
160 170 180 190 200
RAIHQAATHK ELEAISHLGM EFWSSSLNTK DQQRPSEAPP IPRLKARSPQ
210 220 230 240 250
ELDQGTGAAL CFFNPLFPGD LGPTKREKFK RSFKVRVSTE TSSPLSPPAV
260 270 280 290 300
PPPPVPVLPG TSSSQTERLP PRQLLQRESS VGYRVPGSAA SPCLPPLPSL
310 320 330 340 350
QEVDCCSPSS SEEEGSSGSP TTSPRLSRPR HRRPLLRSMS SAFCSLLAPE
360 370 380 390 400
RQVGRAATML MQNRYTAVGQ LVQDLLTQVR AGPEPRELQG IRQALSRARA
410 420 430 440 450
MLSAELGPEK LLPPERLELV LEKSLHRSVL KPLRPILAAR LRRRLSADGS
460 470 480 490 500
LGRLAEGFRL ARTQGPGAFG SHLTLSSPVE TEQVRQKLLQ LLRAYSPSAQ
510 520 530 540 550
VKWLLQACKL LYTALKSQAG ENAGADEFLP LLSLVLAQCD LPDLLLEAEY
560 570 580 590 600
MSELLEPTLL TGEGGYYLTS LSASLALLSG LSQARALPLS PAQELQRSLA
610 620 630 640 650
LWEQRRLPAT HSFQHLLRVA YQDPSTGCTS KTLAVPPGSS IATLSQLCAT
660 670 680 690 700
KFRVTQPDAF GLFLYKDQGY HRLPPEALAH RLPATGYLIY RRAERPETQG
710 720 730 740 750
AVAEKAKTGS KGPEAGAWEE ETGGLNREGK PRIAVDQEGK DQARGGHIGP
760
EEQKAEGSQA LEE
Length:763
Mass (Da):83,014
Last modified:December 1, 2001 - v1
Checksum:i0CE76F66A4773438
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9F2A2A0A2C9F2A2_MOUSE
Ras and Rab interactor 1
Rin1
774Annotation score:
A0A286YCR5A0A286YCR5_MOUSE
Ras and Rab interactor 1
Rin1
193Annotation score:
A0A286YCC1A0A286YCC1_MOUSE
Ras and Rab interactor 1
Rin1
182Annotation score:
A0A286YDC3A0A286YDC3_MOUSE
Ras and Rab interactor 1
Rin1
37Annotation score:
A0A286YDL8A0A286YDL8_MOUSE
Ras and Rab interactor 1
Rin1
39Annotation score:
A0A286YDV8A0A286YDV8_MOUSE
Ras and Rab interactor 1
Rin1
35Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011277 mRNA Translation: AAH11277.1
CCDSiCCDS29447.1
RefSeqiNP_663470.1, NM_145495.2
UniGeneiMm.271922

Genome annotation databases

EnsembliENSMUST00000225427; ENSMUSP00000153189; ENSMUSG00000024883
GeneIDi225870
KEGGimmu:225870
UCSCiuc008gca.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011277 mRNA Translation: AAH11277.1
CCDSiCCDS29447.1
RefSeqiNP_663470.1, NM_145495.2
UniGeneiMm.271922

3D structure databases

ProteinModelPortaliQ921Q7
SMRiQ921Q7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230435, 5 interactors
DIPiDIP-46280N
IntActiQ921Q7, 1 interactor
STRINGi10090.ENSMUSP00000025818

PTM databases

iPTMnetiQ921Q7
PhosphoSitePlusiQ921Q7
SwissPalmiQ921Q7

Proteomic databases

MaxQBiQ921Q7
PaxDbiQ921Q7
PeptideAtlasiQ921Q7
PRIDEiQ921Q7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000225427; ENSMUSP00000153189; ENSMUSG00000024883
GeneIDi225870
KEGGimmu:225870
UCSCiuc008gca.1 mouse

Organism-specific databases

CTDi9610
MGIiMGI:2385695 Rin1

Phylogenomic databases

eggNOGiKOG2320 Eukaryota
ENOG410ZZW5 LUCA
GeneTreeiENSGT00530000063053
HOGENOMiHOG000154128
HOVERGENiHBG036105
InParanoidiQ921Q7
KOiK17638
OrthoDBiEOG091G02V2
PhylomeDBiQ921Q7
TreeFamiTF331067

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q921Q7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024883 Expressed in 210 organ(s), highest expression level in nucleus accumbens
CleanExiMM_RIN1
ExpressionAtlasiQ921Q7 baseline and differential
GenevisibleiQ921Q7 MM

Family and domain databases

CDDicd10393 SH2_RIN1, 1 hit
Gene3Di1.20.1050.80, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000159 RA_dom
IPR035867 RIN1_SH2
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02204 VPS9, 1 hit
SMARTiView protein in SMART
SM00314 RA, 1 hit
SM00252 SH2, 1 hit
SM00167 VPS9, 1 hit
SUPFAMiSSF109993 SSF109993, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS51205 VPS9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIN1_MOUSE
AccessioniPrimary (citable) accession number: Q921Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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