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Entry version 154 (29 Sep 2021)
Sequence version 3 (20 Apr 2010)
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Protein

Golgin subfamily A member 2

Gene

Golga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (PubMed:28028212).

Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (PubMed:28028212).

Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization (By similarity).

Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (By similarity).

Regulates the meiotic spindle pole assembly, probably via the same mechanism (PubMed:21552007).

Also regulates the centrosome organization (By similarity).

Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005, COPII-mediated vesicle transport
R-MMU-6807878, COPI-mediated anterograde transport
R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013405, RHOD GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein
Short name:
GM1302 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Golga2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2139395, Golga2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000002546

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are born at the expected Mendelian rate and have normal weight at birth. However, they display strongly decreased growth during the following weeks and die between 15 and 35 days after birth. Mice diplay ataxia and motor coordination defects that worsen with increasing age. Mice with a neuron-specific gene disruption display normal overall brain architecture, but the size of the cerebellum is strongly reduced in adults. After the third week after birth, a progressive loss of Purkinje cell is observed, leading to cerebellar atrophy. Purkinje cells from mutant mice appear normal at 9 days fater birth, but display a strong decrease of the size and arborization of dendrites, associated with impaired dendritic protein transport. Other neurons in the molecular or granule layer of the cerebellum are not affected. Mice with a neuron-specific gene disruption display decreased growth, but have a normal lifespan and have only mild motor coordination defects at three weeks after birth, but defects are obvious at 8 weeks after birth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900551 – 999Golgin subfamily A member 2Add BLAST999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Dimethylated arginineBy similarity1
Modified residuei30Dimethylated arginineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei273PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei697PhosphoserineBy similarity1
Modified residuei934PhosphoserineBy similarity1
Modified residuei978PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly. A report however suggests that Golgi disassembly is independent of phosphorylation at Ser-37. Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.By similarity
Cleaved by caspases at the onset of apoptosis.By similarity
Methylation by PRMT5 is required for Golgi ribbon formation.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q921M4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q921M4

PeptideAtlas

More...
PeptideAtlasi
Q921M4

PRoteomics IDEntifications database

More...
PRIDEi
Q921M4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
271245 [Q921M4-1]
271246 [Q921M4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q921M4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q921M4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q921M4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, lung, liver, thymus and pancreas (PubMed:28028212). Detected in spermatocytes (PubMed:28617811). Present in oocytes during all oocyte meiotic maturation (at protein level).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002546, Expressed in spleen and 297 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q921M4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q921M4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer, may assemble into homohexamers (By similarity). Homotetramer; forms a parallel homotetramer with a flexible rod-like structure that can give rise to I- and Y-shaped conformations.

Interacts with GORASP1/GRASP65. The homooligomer forms a complex with GORASP1 with a 1:1 stoichiometry (By similarity).

Interacts with RAB1B that has been activated by GTP-binding.

Interacts with p115/USO1; interaction with p115/USO1 inhibits interaction with STX5 and/or RAB1B.

Interacts with STX5 (By similarity).

Interacts with ZFPL1 (By similarity).

Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
221239, 17 interactors

Protein interaction database and analysis system

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IntActi
Q921M4, 7 interactors

Molecular INTeraction database

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MINTi
Q921M4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109004

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q921M4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q921M4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 86Interaction with p115/USO1By similarityAdd BLAST86
Regioni1 – 80DisorderedSequence analysisAdd BLAST80
Regioni244 – 288DisorderedSequence analysisAdd BLAST45
Regioni444 – 468DisorderedSequence analysisAdd BLAST25
Regioni989 – 999Interaction with GORASP1/GRASP65By similarityAdd BLAST11

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili147 – 895Sequence analysisAdd BLAST749

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi26 – 49Nuclear localization signalBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 283Polar residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with long coiled-coil domains.By similarity
The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4725, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000062932

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q921M4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q921M4

TreeFam database of animal gene trees

More...
TreeFami
TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043937, GM130_C
IPR043976, GOLGA_cons_dom
IPR024858, Golgin_A

The PANTHER Classification System

More...
PANTHERi
PTHR10881, PTHR10881, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19046, GM130_C, 1 hit
PF15070, GOLGA2L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q921M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPPRFPPPR PGMSEETRQS KLAAAKKKLR EYQQKNSPGV PAGAKKKKKI
60 70 80 90 100
KNGHSPERPT ASDCQSPENV PTDHIAPAPP TAATDTMFLG VTPSPDADLT
110 120 130 140 150
QSHDAGNCSN LMEETKTFSS TESLRQLSQQ LNGLVSESTS YINGEGLTSS
160 170 180 190 200
NMKELENRYQ ELAVALDSSY VTNKQLSSTI EELKQQNQDT LDQLEKEKKD
210 220 230 240 250
YQQKLAKEQG SLREQLQVHI QTIGILVSEK AELQTALAHT QQAARQKAGE
260 270 280 290 300
SEDLASRLQS SRQRVGELER TLSTVSTQQK QADRYNKDLT KERDALKLEL
310 320 330 340 350
YKNSKSNEDL RQQNSELEEK LRVLVAEKAA AQLGVEELQK KLEMSELLLQ
360 370 380 390 400
QFSSQSSAAG GNEQLQHAME ERAQLETHVS QLMESLKQLQ VERDQYAENL
410 420 430 440 450
KGESAMWQQR VQQMAEQVHT LKEEKEHRER QVQELETSLA ALRSQMEEPP
460 470 480 490 500
PPEPPAGPSE AEEQLQGEVE QLHKELERLT GQLRAQVQDN ESLSHLNREQ
510 520 530 540 550
EGRLLELERE AQRWSEQAEE RKQILESMQS DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQNGFVRLT NENMEITSAL QSEQHVKKEL ARKLGELQER LGELKETVEL
610 620 630 640 650
KSQEAQGLQE QRDQCLSHLQ QYAAAYQQHL AAYEQLTSEK EAIHKQLLLQ
660 670 680 690 700
TQLMDQLQHE EVQGKMAAEL ARQELQEAQE RLKATSQENQ QLQAQLSLLV
710 720 730 740 750
LPGEGDVDQE EEDEEVPQSS LAIPEDLDSR EAMVAFFNAA IARAEEEQAR
760 770 780 790 800
LRVQLKEQKA RCRSLSHLAA PVQSKLEKEA VVPRNVDDSA SEESNQALHV
810 820 830 840 850
AMEKLQSRFL EVMQEKVELK ERVEELEHCC IQLSGETDTI GEYIALYQNQ
860 870 880 890 900
RAVLKARHLE KEEYISRLAQ DKEEMKVKLL ELQELVLRLV NERNEWQGKF
910 920 930 940 950
LAVSQNPGDV LTPVPTGSQE FGAADQQDDL REVSLADDIE PAQGEAGVPA
960 970 980 990
PHENPTAQQI MQLLREIQNP RERPGLGSNP CIPFFYRADE NDEVKIMVV
Length:999
Mass (Da):113,278
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D84161E727EA9F5
GO
Isoform 2 (identifier: Q921M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-101: Missing.

Show »
Length:967
Mass (Da):110,048
Checksum:iC8AB99D83B3205A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUQ5E9PUQ5_MOUSE
Golgin subfamily A member 2
Golga2
1,014Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YJU8Z4YJU8_MOUSE
Golgin subfamily A member 2
Golga2
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AN48A2AN48_MOUSE
Golgin subfamily A member 2
Golga2
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AN46A2AN46_MOUSE
Golgin subfamily A member 2
Golga2
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AN45A2AN45_MOUSE
Golgin subfamily A member 2
Golga2
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8MX07A0A6I8MX07_MOUSE
Golgin subfamily A member 2
Golga2
1,026Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8MWY5A0A6I8MWY5_MOUSE
Golgin subfamily A member 2
Golga2
987Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AN42A2AN42_MOUSE
Golgin subfamily A member 2
Golga2
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11407 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAM15849 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03902770 – 101Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL808027 Genomic DNA Translation: CAM15845.1
AL808027 Genomic DNA Translation: CAM15849.1 Different initiation.
CH466542 Genomic DNA Translation: EDL08537.1
BC011407 mRNA Translation: AAH11407.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001074437.1, NM_001080968.1
XP_006498556.1, XM_006498493.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546 [Q921M4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
99412

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:99412

UCSC genome browser

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UCSCi
uc008jew.1, mouse [Q921M4-1]
uc008jex.1, mouse [Q921M4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808027 Genomic DNA Translation: CAM15845.1
AL808027 Genomic DNA Translation: CAM15849.1 Different initiation.
CH466542 Genomic DNA Translation: EDL08537.1
BC011407 mRNA Translation: AAH11407.1 Different initiation.
RefSeqiNP_001074437.1, NM_001080968.1
XP_006498556.1, XM_006498493.3

3D structure databases

SMRiQ921M4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221239, 17 interactors
IntActiQ921M4, 7 interactors
MINTiQ921M4
STRINGi10090.ENSMUSP00000109004

PTM databases

iPTMnetiQ921M4
PhosphoSitePlusiQ921M4
SwissPalmiQ921M4

Proteomic databases

jPOSTiQ921M4
PaxDbiQ921M4
PeptideAtlasiQ921M4
PRIDEiQ921M4
ProteomicsDBi271245 [Q921M4-1]
271246 [Q921M4-2]

Genome annotation databases

EnsembliENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546 [Q921M4-1]
GeneIDi99412
KEGGimmu:99412
UCSCiuc008jew.1, mouse [Q921M4-1]
uc008jex.1, mouse [Q921M4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2801
MGIiMGI:2139395, Golga2
VEuPathDBiHostDB:ENSMUSG00000002546

Phylogenomic databases

eggNOGiKOG4725, Eukaryota
GeneTreeiENSGT00530000062932
InParanoidiQ921M4
PhylomeDBiQ921M4
TreeFamiTF316990

Enzyme and pathway databases

ReactomeiR-MMU-162658, Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005, COPII-mediated vesicle transport
R-MMU-6807878, COPI-mediated anterograde transport
R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013405, RHOD GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
99412, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Golga2, mouse

Protein Ontology

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PROi
PR:Q921M4
RNActiQ921M4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002546, Expressed in spleen and 297 other tissues
ExpressionAtlasiQ921M4, baseline and differential
GenevisibleiQ921M4, MM

Family and domain databases

InterProiView protein in InterPro
IPR043937, GM130_C
IPR043976, GOLGA_cons_dom
IPR024858, Golgin_A
PANTHERiPTHR10881, PTHR10881, 1 hit
PfamiView protein in Pfam
PF19046, GM130_C, 1 hit
PF15070, GOLGA2L5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q921M4
Secondary accession number(s): A2AN43, A2AN47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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