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Protein

HemK methyltransferase family member 1

Gene

Hemk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei191S-adenosyl-L-methionineBy similarity1
Binding sitei241S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
HemK methyltransferase family member 1 (EC:2.1.1.-)
Gene namesi
Name:Hemk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916786 Hemk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571791 – 340HemK methyltransferase family member 1Add BLAST340

Proteomic databases

EPDiQ921L7
MaxQBiQ921L7
PaxDbiQ921L7
PRIDEiQ921L7
TopDownProteomicsiQ921L7

PTM databases

PhosphoSitePlusiQ921L7

Expressioni

Gene expression databases

BgeeiENSMUSG00000032579 Expressed in 243 organ(s), highest expression level in brown adipose tissue
CleanExiMM_HEMK1
ExpressionAtlasiQ921L7 baseline and differential
GenevisibleiQ921L7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035196

Structurei

3D structure databases

ProteinModelPortaliQ921L7
SMRiQ921L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 172S-adenosyl-L-methionine bindingBy similarity5
Regioni241 – 244Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2904 Eukaryota
COG2890 LUCA
GeneTreeiENSGT00390000014125
HOGENOMiHOG000076274
HOVERGENiHBG081597
InParanoidiQ921L7
KOiK02493
OMAiVLVCEVG
OrthoDBiEOG091G0BZV
TreeFamiTF324423

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q921L7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLWGQILWT LLSVPRGRRG VLQGWAFNSW KTYSSLTGPL SATGMVNHWT
60 70 80 90 100
RVFEERGIPE ARESSEYIVA HVLGAKTFQS LKPALWTKPL TPQQLECIQE
110 120 130 140 150
LCGRRLQRMP VQYILGEWDF QGLSLKMVPP VFIPRPETEE LVEWVLEEVA
160 170 180 190 200
QRPHAVRAQD GPLILEVGCG SGAITLSLLS QLPKSRVVAV DKEEAAVSLT
210 220 230 240 250
HENAQRLQLQ DRIRIIHLDI TSEGCCTHLL PWSPLDLVVS NPPYIFRKDM
260 270 280 290 300
EQLAPEICSY EDLVALDGGD EGMDIITHIL TLAPQLLNAS GSIFLEVDPR
310 320 330 340
HPELVSSWLQ SHPDLHLSLV GVREDFCGRP RFLHVQKSAP
Length:340
Mass (Da):38,233
Last modified:October 3, 2012 - v2
Checksum:i379E5932CE302053
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZV0B0QZV0_MOUSE
HemK methyltransferase family membe...
Hemk1
121Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51R → Q in AAH11431 (PubMed:15489334).Curated1
Sequence conflicti104R → H in AAH11431 (PubMed:15489334).Curated1
Sequence conflicti151Q → R in AAH11431 (PubMed:15489334).Curated1
Sequence conflicti205Q → R in AAH11431 (PubMed:15489334).Curated1
Sequence conflicti217H → C in AAH11431 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672070 Genomic DNA No translation available.
BC011431 mRNA Translation: AAH11431.1
BC024428 mRNA Translation: AAH24428.1
CCDSiCCDS23488.1
RefSeqiNP_598745.2, NM_133984.2
XP_011241215.1, XM_011242913.1
UniGeneiMm.259467

Genome annotation databases

EnsembliENSMUST00000035196; ENSMUSP00000035196; ENSMUSG00000032579
GeneIDi69536
KEGGimmu:69536
UCSCiuc009rle.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672070 Genomic DNA No translation available.
BC011431 mRNA Translation: AAH11431.1
BC024428 mRNA Translation: AAH24428.1
CCDSiCCDS23488.1
RefSeqiNP_598745.2, NM_133984.2
XP_011241215.1, XM_011242913.1
UniGeneiMm.259467

3D structure databases

ProteinModelPortaliQ921L7
SMRiQ921L7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035196

PTM databases

PhosphoSitePlusiQ921L7

Proteomic databases

EPDiQ921L7
MaxQBiQ921L7
PaxDbiQ921L7
PRIDEiQ921L7
TopDownProteomicsiQ921L7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035196; ENSMUSP00000035196; ENSMUSG00000032579
GeneIDi69536
KEGGimmu:69536
UCSCiuc009rle.2 mouse

Organism-specific databases

CTDi51409
MGIiMGI:1916786 Hemk1

Phylogenomic databases

eggNOGiKOG2904 Eukaryota
COG2890 LUCA
GeneTreeiENSGT00390000014125
HOGENOMiHOG000076274
HOVERGENiHBG081597
InParanoidiQ921L7
KOiK02493
OMAiVLVCEVG
OrthoDBiEOG091G0BZV
TreeFamiTF324423

Miscellaneous databases

PROiPR:Q921L7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032579 Expressed in 243 organ(s), highest expression level in brown adipose tissue
CleanExiMM_HEMK1
ExpressionAtlasiQ921L7 baseline and differential
GenevisibleiQ921L7 MM

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEMK1_MOUSE
AccessioniPrimary (citable) accession number: Q921L7
Secondary accession number(s): B0QZU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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