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Protein

Calcium load-activated calcium channel

Gene

Tmco1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).1 Publication

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: UniProtKB
  • endoplasmic reticulum calcium ion homeostasis Source: UniProtKB
  • ER overload response Source: UniProtKB

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium load-activated calcium channelBy similarity
Short name:
CLAC channelBy similarity
Alternative name(s):
Transmembrane and coiled-coil domain-containing protein 1Curated
Gene namesi
Name:Tmco1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921173 Tmco1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicBy similarity9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 90LumenalBy similarityAdd BLAST60
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 137CytoplasmicBy similarityAdd BLAST26
Intramembranei138 – 154Pore-formingBy similarityAdd BLAST17
Topological domaini155 – 188CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are born at a much lower rate than predicted by the Mendelian ratio. Surviving mice show a reduced body size, low survival rate and delayed osteogenesis. Adult mice display craniofacial dysmorphism such as open cranial sutures, flattened faces with shorten nasal bones and skull anomalies. Moreover, magnetic resonance imaging (MRI) of brain shows significantly enlarged brain ventricles, suggesting a mental retardation. Adult mice show defects in spatial recognition memory in a Y-maze task assay and a significant deficiency in motor coordination in rotarod assessments. Defects are probably due to calcium overload, calcium imaging results revealing a significant overload of endoplasmic reticulum calcium in osteoblasts.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440771 – 188Calcium load-activated calcium channelAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei188PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921L3
MaxQBiQ921L3
PaxDbiQ921L3
PRIDEiQ921L3

PTM databases

iPTMnetiQ921L3
PhosphoSitePlusiQ921L3
SwissPalmiQ921L3

Expressioni

Gene expression databases

BgeeiENSMUSG00000052428 Expressed in 288 organ(s), highest expression level in adrenal gland
CleanExiMM_TMCO1
ExpressionAtlasiQ921L3 baseline and differential
GenevisibleiQ921L3 MM

Interactioni

Subunit structurei

Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and endoplasmic reticulum calcium overload.By similarity1 Publication

Protein-protein interaction databases

BioGridi213130, 3 interactors
STRINGi10090.ENSMUSP00000095081

Structurei

3D structure databases

ProteinModelPortaliQ921L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 89Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 183Poly-Pro4

Sequence similaritiesi

Belongs to the TMCO1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3312 Eukaryota
ENOG410XR8B LUCA
GeneTreeiENSGT00390000002659
HOGENOMiHOG000240371
HOVERGENiHBG054437
InParanoidiQ921L3
KOiK21891
OMAiWADTLLI
PhylomeDBiQ921L3
TreeFamiTF315045

Family and domain databases

InterProiView protein in InterPro
IPR002809 EMC3/TMCO1
IPR008559 TMCO1
PANTHERiPTHR20917 PTHR20917, 1 hit
PfamiView protein in Pfam
PF01956 DUF106, 1 hit
PIRSFiPIRSF023322 DUF841_euk, 1 hit
SMARTiView protein in SMART
SM01415 DUF106, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q921L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTMFADTLL IVFISVCTAL LAEGITWVLV YRTDKYKRLK AEVEKQSKKL
60 70 80 90 100
EKKKETITES AGRQQKKKIE RQEEKLKNNN RDLSMVRMKS MFAIGFCFTA
110 120 130 140 150
LMGMFNSIFD GRVVAKLPFT PLSYIQGLSH RNLLGDDTTD CSFIFLYILC
160 170 180
TMSIRQNIQK ILGLAPSRAA TKQAGGFLGP PPPSGKFS
Length:188
Mass (Da):21,175
Last modified:December 1, 2001 - v1
Checksum:iFB77BFC4F0629EB1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YVS2A0A0A6YVS2_MOUSE
Calcium load-activated calcium chan...
Tmco1
200Annotation score:
A0A0A6YW31A0A0A6YW31_MOUSE
Calcium load-activated calcium chan...
Tmco1
127Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037709 mRNA Translation: BAC29856.1
AK162344 mRNA Translation: BAE36865.1
BC011457 mRNA Translation: AAH11457.1
BC019761 mRNA Translation: AAH19761.1
BC020098 mRNA Translation: AAH20098.1
CCDSiCCDS15456.1
RefSeqiNP_001034572.1, NM_001039483.1
UniGeneiMm.330045

Genome annotation databases

EnsembliENSMUST00000097473; ENSMUSP00000095081; ENSMUSG00000052428
ENSMUST00000195015; ENSMUSP00000142042; ENSMUSG00000052428
GeneIDi68944
KEGGimmu:68944
UCSCiuc007dkv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037709 mRNA Translation: BAC29856.1
AK162344 mRNA Translation: BAE36865.1
BC011457 mRNA Translation: AAH11457.1
BC019761 mRNA Translation: AAH19761.1
BC020098 mRNA Translation: AAH20098.1
CCDSiCCDS15456.1
RefSeqiNP_001034572.1, NM_001039483.1
UniGeneiMm.330045

3D structure databases

ProteinModelPortaliQ921L3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213130, 3 interactors
STRINGi10090.ENSMUSP00000095081

PTM databases

iPTMnetiQ921L3
PhosphoSitePlusiQ921L3
SwissPalmiQ921L3

Proteomic databases

EPDiQ921L3
MaxQBiQ921L3
PaxDbiQ921L3
PRIDEiQ921L3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097473; ENSMUSP00000095081; ENSMUSG00000052428
ENSMUST00000195015; ENSMUSP00000142042; ENSMUSG00000052428
GeneIDi68944
KEGGimmu:68944
UCSCiuc007dkv.1 mouse

Organism-specific databases

CTDi54499
MGIiMGI:1921173 Tmco1

Phylogenomic databases

eggNOGiKOG3312 Eukaryota
ENOG410XR8B LUCA
GeneTreeiENSGT00390000002659
HOGENOMiHOG000240371
HOVERGENiHBG054437
InParanoidiQ921L3
KOiK21891
OMAiWADTLLI
PhylomeDBiQ921L3
TreeFamiTF315045

Miscellaneous databases

PROiPR:Q921L3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052428 Expressed in 288 organ(s), highest expression level in adrenal gland
CleanExiMM_TMCO1
ExpressionAtlasiQ921L3 baseline and differential
GenevisibleiQ921L3 MM

Family and domain databases

InterProiView protein in InterPro
IPR002809 EMC3/TMCO1
IPR008559 TMCO1
PANTHERiPTHR20917 PTHR20917, 1 hit
PfamiView protein in Pfam
PF01956 DUF106, 1 hit
PIRSFiPIRSF023322 DUF841_euk, 1 hit
SMARTiView protein in SMART
SM01415 DUF106, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMCO1_MOUSE
AccessioniPrimary (citable) accession number: Q921L3
Secondary accession number(s): Q3TS11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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