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Protein

B-cell CLL/lymphoma 7 protein family member B

Gene

Bcl7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity). May play a role in lung tumor development or progression.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis, Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member B
Gene namesi
Name:Bcl7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1332238 Bcl7b

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398301 – 202B-cell CLL/lymphoma 7 protein family member BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921K9
PaxDbiQ921K9
PeptideAtlasiQ921K9
PRIDEiQ921K9

PTM databases

iPTMnetiQ921K9
PhosphoSitePlusiQ921K9

Expressioni

Gene expression databases

BgeeiENSMUSG00000029681
CleanExiMM_BCL7B
ExpressionAtlasiQ921K9 baseline and differential
GenevisibleiQ921K9 MM

Interactioni

Protein-protein interaction databases

BioGridi198328, 19 interactors
ComplexPortaliCPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
IntActiQ921K9, 18 interactors
STRINGi10090.ENSMUSP00000031692

Structurei

3D structure databases

ProteinModelPortaliQ921K9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095 Eukaryota
ENOG4111TES LUCA
GeneTreeiENSGT00390000002172
HOGENOMiHOG000232196
HOVERGENiHBG008481
InParanoidiQ921K9
OMAiDFTDENS
OrthoDBiEOG091G0T7O
PhylomeDBiQ921K9
TreeFamiTF317441

Family and domain databases

InterProiView protein in InterPro
IPR006804 BCL7
PANTHERiPTHR12767 PTHR12767, 1 hit
PfamiView protein in Pfam
PF04714 BCL_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRSVRAET RSRAKDDIKK VMAAIEKVRK WEKKWVTVGD TSLRIFKWVP
60 70 80 90 100
VTDSKEKEKS KSNNTAAREP NGFPSDASAN SSLLLEFQDE NSNQSSVSDV
110 120 130 140 150
YQLKVDSSTN SSPSPQQSES LSPAHTSDFR TDDSQPPTLG QEILEEPSLP
160 170 180 190 200
ASEVADEPPT LTKEEPVPVE TQTTEEEEDS GAPPLKRFCV DQPVVPQTTS

ES
Length:202
Mass (Da):22,238
Last modified:December 1, 2001 - v1
Checksum:iB5976CFF00AB3CC3
GO
Isoform 2 (identifier: Q921K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-58: KE → GF
     59-202: Missing.

Note: No experimental confirmation available.
Show »
Length:58
Mass (Da):6,740
Checksum:i9E6FE7621B1D07D0
GO

Sequence cautioni

The sequence CAA09501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → D in BAE33030 (PubMed:16141072).Curated1
Sequence conflicti192Q → K in BAE33030 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01928057 – 58KE → GF in isoform 2. 1 Publication2
Alternative sequenceiVSP_01928159 – 202Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011145 mRNA Translation: CAA09501.1 Different initiation.
AK131643 mRNA Translation: BAE20736.1
AK155076 mRNA Translation: BAE33030.1
AK160439 mRNA Translation: BAE35789.1
BC011471 mRNA Translation: AAH11471.1
CCDSiCCDS51660.1 [Q921K9-1]
RefSeqiNP_033875.2, NM_009745.2 [Q921K9-1]
UniGeneiMm.405834

Genome annotation databases

EnsembliENSMUST00000031692; ENSMUSP00000031692; ENSMUSG00000029681 [Q921K9-1]
ENSMUST00000111187; ENSMUSP00000106818; ENSMUSG00000029681 [Q921K9-2]
GeneIDi12054
KEGGimmu:12054
UCSCiuc012een.1 mouse [Q921K9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBCL7B_MOUSE
AccessioniPrimary (citable) accession number: Q921K9
Secondary accession number(s): O89022, Q3TV31, Q3U2W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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