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Entry version 108 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

TRPM8 channel-associated factor 2

Gene

Tcaf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M98.A03

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TRPM8 channel-associated factor 2By similarity
Alternative name(s):
TRP channel-associated factor 2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tcaf2By similarityImported
Synonyms:Fam115c, Fam139a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385258, Tcaf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003201881 – 919TRPM8 channel-associated factor 2Add BLAST919

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q921K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q921K8

PeptideAtlas

More...
PeptideAtlasi
Q921K8

PRoteomics IDEntifications database

More...
PRIDEi
Q921K8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254674

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q921K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q921K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029851, Expressed in prostate gland and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q921K8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity.

Interacts with TRPV6.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231291, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031879

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q921K8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 842Peptidase M60PROSITE-ProRule annotationAdd BLAST300

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCAF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S2AP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011215_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q921K8

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHEGMLC

Database of Orthologous Groups

More...
OrthoDBi
1049811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q921K8

TreeFam database of animal gene trees

More...
TreeFami
TF331520

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029062, Class_I_gatase-like
IPR035423, M60-like_N
IPR042279, Pep_M60_3
IPR031161, Peptidase_M60_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17291, M60-like_N, 1 hit
PF13402, Peptidase_M60, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01276, M60-like, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317, SSF52317, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51723, PEPTIDASE_M60, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q921K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTPDAAFE ALMNGVTSWD LPKEFTPSEL LLIGEAAFPV MVNDKGQVLI
60 70 80 90 100
AVSFYGQGRL VVVSHESYLM HAGLAPFLLN AVSWLCPSPG TPIEVHSSLA
110 120 130 140 150
SLVNILRGSG INALVQPEPG EALGVYCIDA YNDTLTKKLV QFVKRGGGLL
160 170 180 190 200
IGGQAWNWAS QHGSDKVLFS FPGNKVTSVA GVYFTDVYGD INRFKVSKKI
210 220 230 240 250
PKIPLYIRCW EELRHDQDQL LDGISMLDVR TGGVPSQLLV HGSLAFPLGL
260 270 280 290 300
DNSFLSCFLA AAHYGRGRVV LAAHEAMLCA PKMEPFLLNA IRWLSRGQED
310 320 330 340 350
NIGVNTRLKN LNSLLLKHGL KCSLESHLTD DMCVYCCAAY SDQEAKKIQE
360 370 380 390 400
FVAEGGGLLI GGQSWWWASQ NPGSSALGSF PGNVILNTFG LSILPRTVSP
410 420 430 440 450
GCFPILHIDI RNYHFRGALS EFQAMLNHKE GNLEKRYSGK LGVDGAGFLQ
460 470 480 490 500
IPAQGVPAYL SVHRILRKIL RQAGLPAVSK SNPVSSHSYE AAILQLATEL
510 520 530 540 550
AHSGSDCSQI AHNLSSQTCS SNLSSSEHPI TVEINGTNPG DRDVWMSTGL
560 570 580 590 600
YLLEGQSTEI SVSEPAASAG LKVQIGCHTD DLTFAIKLFR APVVTYQCCM
610 620 630 640 650
NRTQRSVSCL WGGLLYIIVP KGCQLGPVSV TITNAVPAPY YKLGKTSLEE
660 670 680 690 700
WKSCIQKNLG PWGELATDNV ILTVPTASLK TLENPEPLLQ LWDEMMQAVA
710 720 730 740 750
RLASQPFPFQ RPERIVADVQ LSAGWMHSGY PIMCHMESVQ ELVSLANIRS
760 770 780 790 800
KGLWGPIHEL GHNQQCRGWE FPPHTTEATC NLWSVYVHET VLGIPRAQAH
810 820 830 840 850
PQLKPEEREK RIKEHLQKGA PLQNWNVWTA LETYLQLQEV FGWEPFITLF
860 870 880 890 900
AEYQTIFYIP EDNECKMNIW LKLFSEKVQK NLVPFFEAWG WPIQKDVAED
910
LACYPSWEDH PLRMYMGSE
Length:919
Mass (Da):101,598
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B0819C108C8A5CF
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD21419 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16V → M in AAH08555 (PubMed:15489334).Curated1
Sequence conflicti36A → V in AAH08555 (PubMed:15489334).Curated1
Sequence conflicti91T → A in AAH08555 (PubMed:15489334).Curated1
Sequence conflicti137K → E in AAH08555 (PubMed:15489334).Curated1
Sequence conflicti280A → T in AAH08555 (PubMed:15489334).Curated1
Sequence conflicti453A → T in AAH08555 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131169 mRNA Translation: BAD21419.1 Different initiation.
BC008555 mRNA Translation: AAH08555.1
BC011487 mRNA Translation: AAH11487.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20075.1

NCBI Reference Sequences

More...
RefSeqi
NP_666286.1, NM_146174.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000031879; ENSMUSP00000031879; ENSMUSG00000029851

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
232748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:232748

UCSC genome browser

More...
UCSCi
uc009brn.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131169 mRNA Translation: BAD21419.1 Different initiation.
BC008555 mRNA Translation: AAH08555.1
BC011487 mRNA Translation: AAH11487.1
CCDSiCCDS20075.1
RefSeqiNP_666286.1, NM_146174.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi231291, 1 interactor
STRINGi10090.ENSMUSP00000031879

Protein family/group databases

MEROPSiM98.A03

PTM databases

iPTMnetiQ921K8
PhosphoSitePlusiQ921K8

Proteomic databases

MaxQBiQ921K8
PaxDbiQ921K8
PeptideAtlasiQ921K8
PRIDEiQ921K8
ProteomicsDBi254674

Genome annotation databases

EnsembliENSMUST00000031879; ENSMUSP00000031879; ENSMUSG00000029851
GeneIDi232748
KEGGimmu:232748
UCSCiuc009brn.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285966
MGIiMGI:2385258, Tcaf2

Phylogenomic databases

eggNOGiENOG502S2AP, Eukaryota
GeneTreeiENSGT00390000017365
HOGENOMiCLU_011215_0_0_1
InParanoidiQ921K8
OMAiAHEGMLC
OrthoDBi1049811at2759
PhylomeDBiQ921K8
TreeFamiTF331520

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
232748, 1 hit in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tcaf2, mouse

Protein Ontology

More...
PROi
PR:Q921K8
RNActiQ921K8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029851, Expressed in prostate gland and 228 other tissues
GenevisibleiQ921K8, MM

Family and domain databases

Gene3Di1.10.390.30, 1 hit
InterProiView protein in InterPro
IPR029062, Class_I_gatase-like
IPR035423, M60-like_N
IPR042279, Pep_M60_3
IPR031161, Peptidase_M60_dom
PfamiView protein in Pfam
PF17291, M60-like_N, 1 hit
PF13402, Peptidase_M60, 1 hit
SMARTiView protein in SMART
SM01276, M60-like, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
PROSITEiView protein in PROSITE
PS51723, PEPTIDASE_M60, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCAF2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q921K8
Secondary accession number(s): Q6KAN8, Q922C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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