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Protein

Serotransferrin

Gene

Tf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi82Iron 1PROSITE-ProRule annotation1
Metal bindingi114Iron 1PROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei139Carbonate 1PROSITE-ProRule annotation1
Binding sitei143Carbonate 1PROSITE-ProRule annotation1
Binding sitei145Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei146Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi207Iron 1PROSITE-ProRule annotation1
Metal bindingi268Iron 1PROSITE-ProRule annotation1
Metal bindingi410Iron 2PROSITE-ProRule annotation1
Metal bindingi448Iron 2PROSITE-ProRule annotation1
Binding sitei474Carbonate 2PROSITE-ProRule annotation1
Binding sitei478Carbonate 2PROSITE-ProRule annotation1
Binding sitei480Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei481Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi537Iron 2PROSITE-ProRule annotation1
Metal bindingi605Iron 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-917937 Iron uptake and transport
R-MMU-917977 Transferrin endocytosis and recycling

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S60.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Siderophilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tf
Synonyms:Trf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98821 Trf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003571620 – 697SerotransferrinAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42Dimethylated arginineBy similarity1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Modified residuei388PhosphoserineBy similarity1
Disulfide bondi420 ↔ 692PROSITE-ProRule annotation
Disulfide bondi435 ↔ 655PROSITE-ProRule annotation
Disulfide bondi472 ↔ 543PROSITE-ProRule annotation
Disulfide bondi496 ↔ 683PROSITE-ProRule annotation
Disulfide bondi506 ↔ 520PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi513N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi517 ↔ 526PROSITE-ProRule annotation
Disulfide bondi583 ↔ 597PROSITE-ProRule annotation
Disulfide bondi633 ↔ 638PROSITE-ProRule annotation
Modified residuei684PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q921I1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q921I1

PeptideAtlas

More...
PeptideAtlasi
Q921I1

PRoteomics IDEntifications database

More...
PRIDEi
Q921I1

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00139788
Q921I1

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q921I1

GlyConnect protein glycosylation platform

More...
GlyConnecti
556

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q921I1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q921I1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q921I1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032554 Expressed in 44 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

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CleanExi
MM_TRF

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q921I1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q921I1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
204313, 1 interactor

Protein interaction database and analysis system

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IntActi
Q921I1, 8 interactors

Molecular INTeraction database

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MINTi
Q921I1

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000035158

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q921I1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q921I1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini360 – 682Transferrin-like 2PROSITE-ProRule annotationAdd BLAST323

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEAI Eukaryota
ENOG410XQ36 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154388

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000055

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q921I1

KEGG Orthology (KO)

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KOi
K14736

Identification of Orthologs from Complete Genome Data

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OMAi
CTVSSHE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0242

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q921I1

TreeFam database of animal gene trees

More...
TreeFami
TF324013

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030685 Serotransferrin_mammal
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00405 Transferrin, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500682 Serotransferrin, 1 hit
PIRSF002549 Transferrin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00422 TRANSFERRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00094 TR_FER, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 1 hit
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q921I1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLTVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
PDGPRLACVK KTSYPDCIKA ISASEADAMT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSVEHP QTYYYAVAVV KKGTDFQLNQ LEGKKSCHTG LGRSAGWVIP
160 170 180 190 200
IGLLFCKLSE PRSPLEKAVS SFFSGSCVPC ADPVAFPKLC QLCPGCGCSS
210 220 230 240 250
TQPFFGYVGA FKCLKDGGGD VAFVKHTTIF EVLPEKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARKNNGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFSSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHNYVT AIRNQQEGVC
360 370 380 390 400
PEGSIDNSPV KWCALSHLER TKCDEWSIIS EGKIECESAE TTEDCIEKIV
410 420 430 440 450
NGEADAMTLD GGHAYIAGQC GLVPVMAEYY ESSNCAIPSQ QGIFPKGYYA
460 470 480 490 500
VAVVKASDTS ITWNNLKGKK SCHTGVDRTA GWNIPMGMLY NRINHCKFDE
510 520 530 540 550
FFSQGCAPGY EKNSTLCDLC IGPLKCAPNN KEEYNGYTGA FRCLVEKGDV
560 570 580 590 600
AFVKHQTVLD NTEGKNPAEW AKNLKQEDFE LLCPDGTRKP VKDFASCHLA
610 620 630 640 650
QAPNHVVVSR KEKAARVKAV LTSQETLFGG SDCTGNFCLF KSTTKDLLFR
660 670 680 690
DDTKCFVKLP EGTTPEKYLG AEYMQSVGNM RKCSTSRLLE ACTFHKH
Length:697
Mass (Da):76,724
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0996A0C3B64CB1B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q2Q7E9Q2Q7_MOUSE
Transferrin
Trf
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q939E9Q939_MOUSE
Transferrin
Trf
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYR8D3YYR8_MOUSE
Transferrin
Trf
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CJN9F7CJN9_MOUSE
Transferrin
Trf
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BAE9F7BAE9_MOUSE
Transferrin
Trf
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3 – 4LT → FA in AAL34533 (Ref. 1) Curated2
Sequence conflicti69K → R in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti71 – 74ISAS → HASG in AAH08559 (PubMed:15489334).Curated4
Sequence conflicti72S → A in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti85W → L in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti104Y → C in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti113Y → S in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti123 – 124GT → ER in AAA40488 (PubMed:3693348).Curated2
Sequence conflicti135K → E in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti283W → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti307P → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti350 – 351CP → SA in AAA39438 (PubMed:3611056).Curated2
Sequence conflicti487G → C in AAA40490 (PubMed:3693348).Curated1
Sequence conflicti527A → D in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti529N → S in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti575K → N in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti697H → S in AAL34533 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF440692 mRNA Translation: AAL34533.1
AK085754 mRNA Translation: BAC39532.1
AK142599 mRNA Translation: BAE25124.1
AK146549 mRNA Translation: BAE27253.1
AK149559 mRNA Translation: BAE28960.1
AK149595 mRNA Translation: BAE28981.1
AK150782 mRNA Translation: BAE29847.1
AK168419 mRNA Translation: BAE40332.1
AK168938 mRNA Translation: BAE40747.1
BC008559 mRNA Translation: AAH08559.1
BC012313 mRNA Translation: AAH12313.1
BC022986 mRNA Translation: AAH22986.1
BC092046 mRNA Translation: AAH92046.1
AF027336 Genomic DNA Translation: AAB84034.1
M23013 mRNA Translation: AAA40488.1
M23014 mRNA Translation: AAA40489.1
M23015 mRNA Translation: AAA40490.1
M23016 mRNA Translation: AAA40491.1
S67217 mRNA Translation: AAB28966.2
J03299 mRNA Translation: AAA39438.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23451.1

Protein sequence database of the Protein Information Resource

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PIRi
A28446

NCBI Reference Sequences

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RefSeqi
NP_598738.1, NM_133977.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.37214

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000035158; ENSMUSP00000035158; ENSMUSG00000032554
ENSMUST00000112645; ENSMUSP00000108264; ENSMUSG00000032554

Database of genes from NCBI RefSeq genomes

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GeneIDi
22041

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:22041

UCSC genome browser

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UCSCi
uc009rgj.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440692 mRNA Translation: AAL34533.1
AK085754 mRNA Translation: BAC39532.1
AK142599 mRNA Translation: BAE25124.1
AK146549 mRNA Translation: BAE27253.1
AK149559 mRNA Translation: BAE28960.1
AK149595 mRNA Translation: BAE28981.1
AK150782 mRNA Translation: BAE29847.1
AK168419 mRNA Translation: BAE40332.1
AK168938 mRNA Translation: BAE40747.1
BC008559 mRNA Translation: AAH08559.1
BC012313 mRNA Translation: AAH12313.1
BC022986 mRNA Translation: AAH22986.1
BC092046 mRNA Translation: AAH92046.1
AF027336 Genomic DNA Translation: AAB84034.1
M23013 mRNA Translation: AAA40488.1
M23014 mRNA Translation: AAA40489.1
M23015 mRNA Translation: AAA40490.1
M23016 mRNA Translation: AAA40491.1
S67217 mRNA Translation: AAB28966.2
J03299 mRNA Translation: AAA39438.1
CCDSiCCDS23451.1
PIRiA28446
RefSeqiNP_598738.1, NM_133977.2
UniGeneiMm.37214

3D structure databases

ProteinModelPortaliQ921I1
SMRiQ921I1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204313, 1 interactor
IntActiQ921I1, 8 interactors
MINTiQ921I1
STRINGi10090.ENSMUSP00000035158

Protein family/group databases

MEROPSiS60.972

PTM databases

CarbonylDBiQ921I1
GlyConnecti556
iPTMnetiQ921I1
PhosphoSitePlusiQ921I1
SwissPalmiQ921I1

2D gel databases

REPRODUCTION-2DPAGEiIPI00139788
Q921I1

Proteomic databases

MaxQBiQ921I1
PaxDbiQ921I1
PeptideAtlasiQ921I1
PRIDEiQ921I1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035158; ENSMUSP00000035158; ENSMUSG00000032554
ENSMUST00000112645; ENSMUSP00000108264; ENSMUSG00000032554
GeneIDi22041
KEGGimmu:22041
UCSCiuc009rgj.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22041
MGIiMGI:98821 Trf

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
GeneTreeiENSGT00940000154388
HOVERGENiHBG000055
InParanoidiQ921I1
KOiK14736
OMAiCTVSSHE
OrthoDBiEOG091G0242
PhylomeDBiQ921I1
TreeFamiTF324013

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-917937 Iron uptake and transport
R-MMU-917977 Transferrin endocytosis and recycling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Trf mouse

Protein Ontology

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PROi
PR:Q921I1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032554 Expressed in 44 organ(s), highest expression level in liver
CleanExiMM_TRF
ExpressionAtlasiQ921I1 baseline and differential
GenevisibleiQ921I1 MM

Family and domain databases

InterProiView protein in InterPro
IPR030685 Serotransferrin_mammal
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405 Transferrin, 2 hits
PIRSFiPIRSF500682 Serotransferrin, 1 hit
PIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 1 hit
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRFE_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q921I1
Secondary accession number(s): O35421
, Q3UBW7, Q58E69, Q61803, Q62357, Q62358, Q62359, Q63915, Q64515, Q8VII5, Q922C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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