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UniProtKB - Q921H8 (THIKA_MOUSE)
Protein
3-ketoacyl-CoA thiolase A, peroxisomal
Gene
Acaa1a
Organism
Mus musculus (Mouse)
Status
Functioni
Responsible for the thiolytic cleavage of straight chain 3-oxoacyl-CoAs. Catalyzes the cleavage of short, medium and long straight chain 3-oxoacyl-CoAs, medium chain 3-oxoacyl-CoAs being the best substrates.
By similarityCatalytic activityi
- EC:2.3.1.16By similarityThis reaction proceeds in the backwardBy similarity direction.
- EC:2.3.1.9By similarityThis reaction proceeds in the backwardBy similarity direction.
- EC:2.3.1.155By similarityThis reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the backwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 123 | Acyl-thioester intermediateBy similarity | 1 | |
Active sitei | 377 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 408 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acetate CoA-transferase activity Source: MGI
- acetyl-CoA C-acetyltransferase activity Source: MGI
- acetyl-CoA C-acyltransferase activity Source: UniProtKB
- acetyl-CoA C-myristoyltransferase activity Source: UniProtKB
- palmitoyl-CoA oxidase activity Source: MGI
GO - Biological processi
- bile acid metabolic process Source: UniProtKB
- fatty acid beta-oxidation Source: UniProtKB
- fatty acid metabolic process Source: MGI
- phenylacetate catabolic process Source: GO_Central
- very long-chain fatty acid metabolic process Source: MGI
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.16, 3474 |
UniPathwayi | UPA00199 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2148491, Acaa1a |
VEuPathDBi | HostDB:ENSMUSG00000036138 |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Mitochondrion
- mitochondrion Source: MGI
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisome Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 26 | PeroxisomeBy similarityAdd BLAST | 26 | |
ChainiPRO_0000034068 | 27 – 424 | 3-ketoacyl-CoA thiolase A, peroxisomalAdd BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 234 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q921H8 |
jPOSTi | Q921H8 |
MaxQBi | Q921H8 |
PaxDbi | Q921H8 |
PeptideAtlasi | Q921H8 |
PRIDEi | Q921H8 |
ProteomicsDBi | 262916 |
PTM databases
iPTMneti | Q921H8 |
PhosphoSitePlusi | Q921H8 |
SwissPalmi | Q921H8 |
Expressioni
Tissue specificityi
Mainly expressed in liver and intestine.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000036138, Expressed in sciatic nerve and 326 other tissues |
ExpressionAtlasi | Q921H8, baseline and differential |
Genevisiblei | Q921H8, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 227535, 5 interactors |
IntActi | Q921H8, 4 interactors |
MINTi | Q921H8 |
STRINGi | 10090.ENSMUSP00000042351 |
Miscellaneous databases
RNActi | Q921H8, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1389, Eukaryota |
GeneTreei | ENSGT01030000234626 |
HOGENOMi | CLU_031026_1_1_1 |
InParanoidi | Q921H8 |
OMAi | AFPQFGN |
OrthoDBi | 1129049at2759 |
PhylomeDBi | Q921H8 |
TreeFami | TF332308 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q921H8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRLQVVLGH LAGRPESSSA LQAAPCSARF PQASASDVVV VHGRRTPIGR
60 70 80 90 100
ASRGGFKNTT PDELLSAVLT AVLQDVRLKP EQLGDISVGN VLEPGAGAVM
110 120 130 140 150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMSLSGMGN PGNISSRLLE SEKARDCLTP MGMTSENVAE RFGISRQKQD
210 220 230 240 250
DFALASQQKA ASAQSRGCFR AEIVPVTTTV LDDKGDKKTI TVSQDEGVRP
260 270 280 290 300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BJZ9 | H3BJZ9_MOUSE | 3-ketoacyl-CoA thiolase A, peroxiso... | Acaa1a | 331 | Annotation score: | ||
H3BKL5 | H3BKL5_MOUSE | 3-ketoacyl-CoA thiolase A, peroxiso... | Acaa1a | 373 | Annotation score: | ||
H3BJG8 | H3BJG8_MOUSE | 3-ketoacyl-CoA thiolase A, peroxiso... | Acaa1a | 114 | Annotation score: | ||
H3BKA1 | H3BKA1_MOUSE | 3-ketoacyl-CoA thiolase A, peroxiso... | Acaa1a | 199 | Annotation score: | ||
H3BJC1 | H3BJC1_MOUSE | 3-ketoacyl-CoA thiolase A, peroxiso... | Acaa1a | 98 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY273811 mRNA Translation: AAP31668.1 AY304542 Genomic DNA Translation: AAP72964.1 BC012400 mRNA Translation: AAH12400.1 |
CCDSi | CCDS23613.1 |
RefSeqi | NP_570934.1, NM_130864.3 XP_006511986.1, XM_006511923.1 |
Genome annotation databases
Ensembli | ENSMUST00000039784; ENSMUSP00000042351; ENSMUSG00000036138 |
GeneIDi | 113868 |
KEGGi | mmu:113868 |
UCSCi | uc009sas.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY273811 mRNA Translation: AAP31668.1 AY304542 Genomic DNA Translation: AAP72964.1 BC012400 mRNA Translation: AAH12400.1 |
CCDSi | CCDS23613.1 |
RefSeqi | NP_570934.1, NM_130864.3 XP_006511986.1, XM_006511923.1 |
3D structure databases
SMRi | Q921H8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 227535, 5 interactors |
IntActi | Q921H8, 4 interactors |
MINTi | Q921H8 |
STRINGi | 10090.ENSMUSP00000042351 |
PTM databases
iPTMneti | Q921H8 |
PhosphoSitePlusi | Q921H8 |
SwissPalmi | Q921H8 |
Proteomic databases
EPDi | Q921H8 |
jPOSTi | Q921H8 |
MaxQBi | Q921H8 |
PaxDbi | Q921H8 |
PeptideAtlasi | Q921H8 |
PRIDEi | Q921H8 |
ProteomicsDBi | 262916 |
Genome annotation databases
Ensembli | ENSMUST00000039784; ENSMUSP00000042351; ENSMUSG00000036138 |
GeneIDi | 113868 |
KEGGi | mmu:113868 |
UCSCi | uc009sas.1, mouse |
Organism-specific databases
CTDi | 113868 |
MGIi | MGI:2148491, Acaa1a |
VEuPathDBi | HostDB:ENSMUSG00000036138 |
Phylogenomic databases
eggNOGi | KOG1389, Eukaryota |
GeneTreei | ENSGT01030000234626 |
HOGENOMi | CLU_031026_1_1_1 |
InParanoidi | Q921H8 |
OMAi | AFPQFGN |
OrthoDBi | 1129049at2759 |
PhylomeDBi | Q921H8 |
TreeFami | TF332308 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
BRENDAi | 2.3.1.16, 3474 |
Miscellaneous databases
BioGRID-ORCSi | 113868, 2 hits in 65 CRISPR screens |
ChiTaRSi | Acaa1a, mouse |
PROi | PR:Q921H8 |
RNActi | Q921H8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036138, Expressed in sciatic nerve and 326 other tissues |
ExpressionAtlasi | Q921H8, baseline and differential |
Genevisiblei | Q921H8, MM |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THIKA_MOUSE | |
Accessioni | Q921H8Primary (citable) accession number: Q921H8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families