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Protein

3-ketoacyl-CoA thiolase A, peroxisomal

Gene

Acaa1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123Acyl-thioester intermediateBy similarity1
Active sitei377Proton acceptorPROSITE-ProRule annotation1
Active sitei408Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.16 3474
ReactomeiR-MMU-2046106 alpha-linolenic acid (ALA) metabolism
R-MMU-390247 Beta-oxidation of very long chain fatty acids
R-MMU-6798695 Neutrophil degranulation
R-MMU-9033241 Peroxisomal protein import
UniPathwayi
UPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase A, peroxisomal (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase A
Beta-ketothiolase A
Peroxisomal 3-oxoacyl-CoA thiolase A
Gene namesi
Name:Acaa1a
Synonyms:Acaa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2148491 Acaa1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26PeroxisomeBy similarityAdd BLAST26
ChainiPRO_000003406827 – 4243-ketoacyl-CoA thiolase A, peroxisomalAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173N6-acetyllysineCombined sources1
Modified residuei234N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ921H8
MaxQBiQ921H8
PaxDbiQ921H8
PeptideAtlasiQ921H8
PRIDEiQ921H8

PTM databases

iPTMnetiQ921H8
PhosphoSitePlusiQ921H8
SwissPalmiQ921H8

Expressioni

Tissue specificityi

Mainly expressed in liver and intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000036138 Expressed in 305 organ(s), highest expression level in sciatic nerve
CleanExiMM_ACAA1A
ExpressionAtlasiQ921H8 baseline and differential
GenevisibleiQ921H8 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi227535, 1 interactor
IntActiQ921H8, 6 interactors
MINTiQ921H8
STRINGi10090.ENSMUSP00000042351

Structurei

3D structure databases

ProteinModelPortaliQ921H8
SMRiQ921H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1389 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00910000144143
HOGENOMiHOG000012239
HOVERGENiHBG003112
InParanoidiQ921H8
KOiK07513
OMAiGVQLNRM
OrthoDBiEOG091G09C6
PhylomeDBiQ921H8
TreeFamiTF332308

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q921H8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRLQVVLGH LAGRPESSSA LQAAPCSARF PQASASDVVV VHGRRTPIGR
60 70 80 90 100
ASRGGFKNTT PDELLSAVLT AVLQDVRLKP EQLGDISVGN VLEPGAGAVM
110 120 130 140 150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMSLSGMGN PGNISSRLLE SEKARDCLTP MGMTSENVAE RFGISRQKQD
210 220 230 240 250
DFALASQQKA ASAQSRGCFR AEIVPVTTTV LDDKGDKKTI TVSQDEGVRP
260 270 280 290 300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Length:424
Mass (Da):43,953
Last modified:December 1, 2001 - v1
Checksum:i56F30DF43198C9A8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKL5H3BKL5_MOUSE
3-ketoacyl-CoA thiolase A, peroxiso...
Acaa1a
373Annotation score:
H3BJZ9H3BJZ9_MOUSE
3-ketoacyl-CoA thiolase A, peroxiso...
Acaa1a
331Annotation score:
H3BKA1H3BKA1_MOUSE
3-ketoacyl-CoA thiolase A, peroxiso...
Acaa1a
199Annotation score:
H3BJG8H3BJG8_MOUSE
3-ketoacyl-CoA thiolase A, peroxiso...
Acaa1a
114Annotation score:
H3BJC1H3BJC1_MOUSE
3-ketoacyl-CoA thiolase A, peroxiso...
Acaa1a
98Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273811 mRNA Translation: AAP31668.1
AY304542 Genomic DNA Translation: AAP72964.1
BC012400 mRNA Translation: AAH12400.1
CCDSiCCDS23613.1
RefSeqiNP_570934.1, NM_130864.3
XP_006511986.1, XM_006511923.1
UniGeneiMm.205266

Genome annotation databases

EnsembliENSMUST00000039784; ENSMUSP00000042351; ENSMUSG00000036138
GeneIDi113868
KEGGimmu:113868
UCSCiuc009sas.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTHIKA_MOUSE
AccessioniPrimary (citable) accession number: Q921H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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