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Protein

Leucine-rich repeat and calponin homology domain-containing protein 4

Gene

Lrch4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 4
Gene namesi
Name:Lrch4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917193 Lrch4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844811 – 680Leucine-rich repeat and calponin homology domain-containing protein 4Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei313PhosphoserineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei513PhosphoserineBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei586PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921G6
MaxQBiQ921G6
PaxDbiQ921G6
PeptideAtlasiQ921G6
PRIDEiQ921G6

PTM databases

iPTMnetiQ921G6
PhosphoSitePlusiQ921G6

Expressioni

Gene expression databases

BgeeiENSMUSG00000029720 Expressed in 19 organ(s), highest expression level in spleen
ExpressionAtlasiQ921G6 baseline and differential
GenevisibleiQ921G6 MM

Interactioni

Protein-protein interaction databases

BioGridi231166, 1 interactor
STRINGi10090.ENSMUSP00000135286

Structurei

3D structure databases

ProteinModelPortaliQ921G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 64LRR 1Add BLAST22
Repeati69 – 90LRR 2Add BLAST22
Repeati92 – 114LRR 3Add BLAST23
Repeati115 – 136LRR 4Add BLAST22
Repeati137 – 158LRR 5Add BLAST22
Repeati160 – 182LRR 6Add BLAST23
Repeati183 – 205LRR 7Add BLAST23
Repeati206 – 226LRR 8Add BLAST21
Repeati228 – 249LRR 9Add BLAST22
Domaini531 – 644Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiQ921G6
OMAiVWGAPRK
OrthoDBiEOG091G05CB
PhylomeDBiQ921G6
TreeFamiTF318428

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q921G6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVAGPLA AGGEEAAASV SLPGSPGLPG SRSAERALEE AVATGTLNLS
60 70 80 90 100
NRRLKHFPRG AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH
110 120 130 140 150
NCLKCLNPAL GNLTALTYLN LSRNQLSSLP PYICQLPLRV LIISNNKLGA
160 170 180 190 200
LPPDISTLGS LRQLDVSSNE LQSLPVELCS LRSLRDLNVR RNQLSTLPDE
210 220 230 240 250
LGDLPLVRLD FSCNRISRIP VSFCRLRHLQ VVLLDSNPLQ SPPAQICLKG
260 270 280 290 300
KLHIFKYLTM EAGRRGAALG DLVPSRPPSF SPCPAEDLFP GRRYDGGLDS
310 320 330 340 350
GFHSVDSGSK RWSGNESTDD FSELSFRISE LARDPRGPRQ PREDGAGDGD
360 370 380 390 400
LEQIDFIDSH VPGEDEDRSA AEEQLPSELS LVAGDVEKPS SSRREEPAGE
410 420 430 440 450
ERRRPDTLQL WQERERKQQQ QSGGWGSPRK DSVLKRGIRA AGAGASAPST
460 470 480 490 500
QATCNGPPKS STTQLGVSGG QGAPTPPPTS QDPLPVSGPV TAPVPRPLGS
510 520 530 540 550
IQRPNSFLFR SSSQSGSSPS SPESVLRPRP FPQEKELISQ LRQVLESRLQ
560 570 580 590 600
QPLPEDLAEA LANGVLLCQL ANQLRPRSVP FIHVPSPAVP KLSALKSRKN
610 620 630 640 650
VESFLEACRK MGVPEADLCS PSDLLRGTAQ GLQTVLEAVI LVGGKAPLPV
660 670 680
QPSSGLGGFL LFYVVFMLLL YVVYTRLLGS
Length:680
Mass (Da):73,163
Last modified:December 1, 2001 - v1
Checksum:iBE7A0567B346C251
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BIX9H3BIX9_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
626Annotation score:
H3BLL3H3BLL3_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
649Annotation score:
H3BK42H3BK42_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
145Annotation score:
H3BJU9H3BJU9_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
139Annotation score:
H3BLB4H3BLB4_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
99Annotation score:
H3BL36H3BL36_MOUSE
Leucine-rich repeat and calponin ho...
Lrch4
79Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012525 mRNA Translation: AAH12525.1
CCDSiCCDS19772.1
RefSeqiNP_666276.1, NM_146164.2
UniGeneiMm.200763

Genome annotation databases

EnsembliENSMUST00000031734; ENSMUSP00000031734; ENSMUSG00000093445
ENSMUST00000177545; ENSMUSP00000135286; ENSMUSG00000029720
GeneIDi231798
KEGGimmu:231798

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012525 mRNA Translation: AAH12525.1
CCDSiCCDS19772.1
RefSeqiNP_666276.1, NM_146164.2
UniGeneiMm.200763

3D structure databases

ProteinModelPortaliQ921G6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231166, 1 interactor
STRINGi10090.ENSMUSP00000135286

PTM databases

iPTMnetiQ921G6
PhosphoSitePlusiQ921G6

Proteomic databases

EPDiQ921G6
MaxQBiQ921G6
PaxDbiQ921G6
PeptideAtlasiQ921G6
PRIDEiQ921G6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031734; ENSMUSP00000031734; ENSMUSG00000093445
ENSMUST00000177545; ENSMUSP00000135286; ENSMUSG00000029720
GeneIDi231798
KEGGimmu:231798

Organism-specific databases

CTDi4034
MGIiMGI:1917193 Lrch4

Phylogenomic databases

eggNOGiKOG0532 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00930000150841
HOGENOMiHOG000049055
HOVERGENiHBG052350
InParanoidiQ921G6
OMAiVWGAPRK
OrthoDBiEOG091G05CB
PhylomeDBiQ921G6
TreeFamiTF318428

Miscellaneous databases

PROiPR:Q921G6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029720 Expressed in 19 organ(s), highest expression level in spleen
ExpressionAtlasiQ921G6 baseline and differential
GenevisibleiQ921G6 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51450 LRR, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRCH4_MOUSE
AccessioniPrimary (citable) accession number: Q921G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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