UniProtKB - Q921C5 (BICD2_MOUSE)
Protein bicaudal D homolog 2
Bicd2
Functioni
GO - Molecular functioni
- cytoskeletal anchor activity Source: InterPro
- dynactin binding Source: UniProtKB
- dynein complex binding Source: UniProtKB
- dynein light intermediate chain binding Source: FlyBase
- Rab GTPase binding Source: BHF-UCL
GO - Biological processi
- centrosome localization Source: UniProtKB
- microtubule anchoring at microtubule organizing center Source: BHF-UCL
- microtubule-based movement Source: MGI
- minus-end-directed organelle transport along microtubule Source: BHF-UCL
- mRNA transport Source: UniProtKB-KW
- protein localization to Golgi apparatus Source: UniProtKB
- protein localization to organelle Source: GO_Central
- protein transport Source: UniProtKB-KW
- regulation of microtubule cytoskeleton organization Source: MGI
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Protein bicaudal D homolog 2Short name: Bic-D 2 |
Gene namesi | Name:Bicd2 Synonyms:Kiaa0699 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924145, Bicd2 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Golgi apparatus
- Golgi apparatus 3 Publications
Nucleus
- nuclear pore complex By similarity
- Nucleus envelope By similarity
Other locations
- Cytoplasm By similarity
Note: In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity).By similarity1 Publication
Cytoskeleton
- centrosome Source: MGI
Cytosol
- cytosol Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nuclear envelope Source: UniProtKB
- nuclear pore Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- annulate lamellae Source: UniProtKB
- cytoplasm Source: MGI
- cytoplasmic vesicle Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Golgi apparatus, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000205360 | 2 – 820 | Protein bicaudal D homolog 2Add BLAST | 819 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineBy similarity | 1 | |
Modified residuei | 224 | PhosphoserineBy similarity | 1 | |
Modified residuei | 320 | PhosphoserineBy similarity | 1 | |
Modified residuei | 321 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 397 | PhosphoserineBy similarity | 1 | |
Modified residuei | 570 | PhosphoserineBy similarity | 1 | |
Modified residuei | 578 | PhosphoserineCombined sources | 1 | |
Modified residuei | 598 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 819 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q921C5 |
PaxDbi | Q921C5 |
PeptideAtlasi | Q921C5 |
PRIDEi | Q921C5 |
PTM databases
iPTMneti | Q921C5 |
PhosphoSitePlusi | Q921C5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000037933, Expressed in rostral migratory stream and 306 other tissues |
Genevisiblei | Q921C5, MM |
Interactioni
Subunit structurei
Interacts with CPNE4 (via VWFA domain) (PubMed:12522145).
Interacts with NEK9 (By similarity).
Interacts with DCTN2 (PubMed:11483508, PubMed:22956769).
Interacts with RAB6A (PubMed:12447383, PubMed:25962623).
Interacts with DNAI1 (By similarity).
Interacts with DYNLL1, DYNC1H1, DYNC1I2 and DCTN1 (PubMed:22956769).
Forms a complex with dynein and dynactin (PubMed:24986880). The dynein-dynactin-BICD2 ternary complex (DDB) binds preferentially to tyrosinated microtubules than to detyrosinated microtubules (PubMed:26968983).
Interacts with RANBP2, RAB6A and KIF5A (PubMed:20386726).
Interacts with KIF1C (By similarity).
By similarity9 PublicationsBinary interactionsi
Hide detailsQ921C5
With | #Exp. | IntAct |
---|---|---|
Rab6a [P35279] | 3 | EBI-642984,EBI-444674 |
Isoform 1 [Q921C5-1]
With | #Exp. | IntAct |
---|---|---|
RANBP2 [P49792] from Homo sapiens. | 4 | EBI-642995,EBI-973138 |
GO - Molecular functioni
- dynactin binding Source: UniProtKB
- dynein light intermediate chain binding Source: FlyBase
- Rab GTPase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 218383, 17 interactors |
DIPi | DIP-49453N |
IntActi | Q921C5, 19 interactors |
MINTi | Q921C5 |
STRINGi | 10090.ENSMUSP00000039394 |
Miscellaneous databases
RNActi | Q921C5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 400 | Interaction with DYNLL1, DYNC1H1, DYNC1I2, DCTN1 and DCTN21 PublicationAdd BLAST | 376 | |
Regioni | 336 – 595 | Interaction with KIF5A1 PublicationAdd BLAST | 260 | |
Regioni | 586 – 820 | Interaction with RANBP21 PublicationAdd BLAST | 235 | |
Regioni | 662 – 810 | Interaction with RAB6A3 PublicationsAdd BLAST | 149 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 20 – 270 | Sequence analysisAdd BLAST | 251 | |
Coiled coili | 340 – 539 | Sequence analysisAdd BLAST | 200 | |
Coiled coili | 662 – 804 | Sequence analysisAdd BLAST | 143 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0999, Eukaryota |
GeneTreei | ENSGT00940000154471 |
InParanoidi | Q921C5 |
OMAi | SLYHHVC |
OrthoDBi | 542877at2759 |
PhylomeDBi | Q921C5 |
TreeFami | TF323833 |
Family and domain databases
InterProi | View protein in InterPro IPR018477, BICD |
PANTHERi | PTHR31233, PTHR31233, 1 hit |
Pfami | View protein in Pfam PF09730, BicD, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAPSEEEEY ARLVMEAQPE WLRAEVKRLS HELAETTREK IQAAEYGLAV
60 70 80 90 100
LEEKHQLKLQ FEELEVDYEA IRSEMEQLKE AFGQAHTNHK KVAADGESRE
110 120 130 140 150
ESLIQESASK EQYYVRKVLE LQTELKQLRN VLTNTQSENE RLTSVAQELK
160 170 180 190 200
EINQNVEIQR GRLRDDIKEY KFREARLLQD YSELEEENIS LQKQVSVLRQ
210 220 230 240 250
NQVEFEGLKH EIKRLEEETE YLNSQLEDAI RLKEISERQL EEALETLKTE
260 270 280 290 300
REQKNNLRKE LSHYMSINDS FYTSHLQVSL DGLKFSDDTV TAEPNNDAEA
310 320 330 340 350
LVNGFEHSGL VKSSLDNKTS TPRKDGLAPP SPSLVSDLLS ELHISEIQKL
360 370 380 390 400
KQQLVQMERE KVGLLATLQD TQKQLEQARG TLSEQHEKVN RLTENLSALR
410 420 430 440 450
RLQAGKERQT SLDNEKDRDS HEDGDYYEVD INGPEILACK YHVAVAEAGE
460 470 480 490 500
LREQLKALRS THEAREAQHA EEKGRYEAEG QALTEKISLL EKASHQDREL
510 520 530 540 550
LAHLEKELKK VSDVAGETQG SLNVAQDELV TFSEELANLY HHVCMCNNET
560 570 580 590 600
PNRVMLDYYR EGQGKAGRTS PEGRGRRSPV LLPKGLLATE VGRADGGTGD
610 620 630 640 650
NSPSPSSSLP SPLSDPRREP MNIYNLIAII RDQIKHLQAA VDRTTELSRQ
660 670 680 690 700
RIASQELGPA VDKDKEALME EILKLKSLLS TKREQITTLR TVLKANKQTA
710 720 730 740 750
EVALANLKSK YENEKAMVTE TMMKLRNELK ALKEDAATFS SLRAMFATRC
760 770 780 790 800
DEYITQLDEM QRQLAAAEDE KKTLNSLLRM AIQQKLALTQ RLELLELDHE
810 820
QTRRGRSKAA SKAKPASPSL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VIQ5 | A0A1Y7VIQ5_MOUSE | Protein bicaudal D homolog 2 | Bicd2 | 87 | Annotation score: | ||
D3Z390 | D3Z390_MOUSE | Protein bicaudal D homolog 2 | Bicd2 | 746 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007971 | 328 – 338 | APPSPSLVSDL → VHPLHALCLTV in isoform 3. CuratedAdd BLAST | 11 | |
Alternative sequenceiVSP_007972 | 339 – 820 | Missing in isoform 3. CuratedAdd BLAST | 482 | |
Alternative sequenceiVSP_007970 | 820 | L → VSHTCACASERAEGAGLANQ VFCSEKHSIYCD in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250106 mRNA Translation: CAC51393.1 AK122348 mRNA Translation: BAC65630.1 Different initiation. BC032198 mRNA Translation: AAH32198.1 AK002683 mRNA Translation: BAB22282.1 Frameshift. AK003456 mRNA Translation: BAC25035.1 |
CCDSi | CCDS36656.1 [Q921C5-1] CCDS36657.1 [Q921C5-2] |
RefSeqi | NP_001034268.1, NM_001039179.2 [Q921C5-2] NP_001034269.1, NM_001039180.2 NP_084067.1, NM_029791.4 [Q921C5-1] |
Genome annotation databases
Ensembli | ENSMUST00000048544; ENSMUSP00000039394; ENSMUSG00000037933 [Q921C5-2] ENSMUST00000110085; ENSMUSP00000105712; ENSMUSG00000037933 [Q921C5-1] |
GeneIDi | 76895 |
KEGGi | mmu:76895 |
UCSCi | uc007qjg.2, mouse [Q921C5-1] uc007qji.2, mouse [Q921C5-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ250106 mRNA Translation: CAC51393.1 AK122348 mRNA Translation: BAC65630.1 Different initiation. BC032198 mRNA Translation: AAH32198.1 AK002683 mRNA Translation: BAB22282.1 Frameshift. AK003456 mRNA Translation: BAC25035.1 |
CCDSi | CCDS36656.1 [Q921C5-1] CCDS36657.1 [Q921C5-2] |
RefSeqi | NP_001034268.1, NM_001039179.2 [Q921C5-2] NP_001034269.1, NM_001039180.2 NP_084067.1, NM_029791.4 [Q921C5-1] |
3D structure databases
SMRi | Q921C5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 218383, 17 interactors |
DIPi | DIP-49453N |
IntActi | Q921C5, 19 interactors |
MINTi | Q921C5 |
STRINGi | 10090.ENSMUSP00000039394 |
PTM databases
iPTMneti | Q921C5 |
PhosphoSitePlusi | Q921C5 |
Proteomic databases
jPOSTi | Q921C5 |
PaxDbi | Q921C5 |
PeptideAtlasi | Q921C5 |
PRIDEi | Q921C5 |
Protocols and materials databases
Antibodypediai | 13783, 196 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048544; ENSMUSP00000039394; ENSMUSG00000037933 [Q921C5-2] ENSMUST00000110085; ENSMUSP00000105712; ENSMUSG00000037933 [Q921C5-1] |
GeneIDi | 76895 |
KEGGi | mmu:76895 |
UCSCi | uc007qjg.2, mouse [Q921C5-1] uc007qji.2, mouse [Q921C5-2] |
Organism-specific databases
CTDi | 23299 |
MGIi | MGI:1924145, Bicd2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0999, Eukaryota |
GeneTreei | ENSGT00940000154471 |
InParanoidi | Q921C5 |
OMAi | SLYHHVC |
OrthoDBi | 542877at2759 |
PhylomeDBi | Q921C5 |
TreeFami | TF323833 |
Enzyme and pathway databases
Reactomei | R-MMU-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 76895, 2 hits in 17 CRISPR screens |
ChiTaRSi | Bicd2, mouse |
PROi | PR:Q921C5 |
RNActi | Q921C5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037933, Expressed in rostral migratory stream and 306 other tissues |
Genevisiblei | Q921C5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR018477, BICD |
PANTHERi | PTHR31233, PTHR31233, 1 hit |
Pfami | View protein in Pfam PF09730, BicD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BICD2_MOUSE | |
Accessioni | Q921C5Primary (citable) accession number: Q921C5 Secondary accession number(s): Q80TU1, Q8BTE3, Q9DCL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families