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Entry version 159 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Bromodomain and WD repeat-containing protein 1

Gene

Brwd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1266695, Interleukin-7 signaling
R-MMU-3247509, Chromatin modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 1
Alternative name(s):
WD repeat-containing protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brwd1
Synonyms:Wdr9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890651, Brwd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002359861 – 2304Bromodomain and WD repeat-containing protein 1Add BLAST2304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei687PhosphothreonineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei702PhosphoserineBy similarity1
Modified residuei711PhosphoserineBy similarity1
Modified residuei1291PhosphoserineBy similarity1
Modified residuei1481PhosphoserineBy similarity1
Modified residuei1609PhosphoserineCombined sources1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1682PhosphoserineBy similarity1
Modified residuei1686PhosphoserineBy similarity1
Modified residuei1689PhosphoserineBy similarity1
Modified residuei1751PhosphoserineCombined sources1
Modified residuei1752PhosphoserineCombined sources1
Modified residuei1782PhosphoserineCombined sources1
Modified residuei1784PhosphoserineCombined sources1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1810PhosphoserineCombined sources1
Modified residuei1830PhosphoserineCombined sources1
Modified residuei1853PhosphothreonineCombined sources1
Modified residuei1857PhosphoserineCombined sources1
Modified residuei1889PhosphoserineBy similarity1
Modified residuei1890PhosphoserineBy similarity1
Modified residuei1927PhosphoserineBy similarity1
Modified residuei1939PhosphothreonineCombined sources1
Modified residuei2004PhosphoserineBy similarity1
Modified residuei2040PhosphoserineCombined sources1
Modified residuei2151PhosphothreonineCombined sources1
Modified residuei2153PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q921C3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q921C3

PRoteomics IDEntifications database

More...
PRIDEi
Q921C3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
265240 [Q921C3-1]
265241 [Q921C3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q921C3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q921C3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Broadly expressed during development. Expression begins to increase at 7.5 dpc, peaks at 10.5-11.5 dpc, and decreases from 14.5 dpc. Weakly expressed at late embryonic stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022914, Expressed in secondary oocyte and 332 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q921C3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q921C3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMARCA4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
220337, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q921C3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023631

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q921C3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati184 – 223WD 1Add BLAST40
Repeati226 – 265WD 2Add BLAST40
Repeati268 – 311WD 3Add BLAST44
Repeati322 – 365WD 4Add BLAST44
Repeati366 – 405WD 5Add BLAST40
Repeati424 – 463WD 6Add BLAST40
Repeati466 – 506WD 7Add BLAST41
Repeati514 – 553WD 8Add BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1178 – 1248Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1332 – 1402Bromo 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni663 – 709DisorderedSequence analysisAdd BLAST47
Regioni810 – 881DisorderedSequence analysisAdd BLAST72
Regioni896 – 926DisorderedSequence analysisAdd BLAST31
Regioni1278 – 1300DisorderedSequence analysisAdd BLAST23
Regioni1438 – 1521DisorderedSequence analysisAdd BLAST84
Regioni1542 – 1596DisorderedSequence analysisAdd BLAST55
Regioni1648 – 1723DisorderedSequence analysisAdd BLAST76
Regioni1741 – 1796DisorderedSequence analysisAdd BLAST56
Regioni1811 – 2085DisorderedSequence analysisAdd BLAST275
Regioni2117 – 2189DisorderedSequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi810 – 837Polar residuesSequence analysisAdd BLAST28
Compositional biasi840 – 856Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi857 – 874Polar residuesSequence analysisAdd BLAST18
Compositional biasi1464 – 1511Polar residuesSequence analysisAdd BLAST48
Compositional biasi1542 – 1575Polar residuesSequence analysisAdd BLAST34
Compositional biasi1677 – 1695Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1696 – 1713Polar residuesSequence analysisAdd BLAST18
Compositional biasi1747 – 1761Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1762 – 1780Polar residuesSequence analysisAdd BLAST19
Compositional biasi1811 – 1828Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1864 – 1879Polar residuesSequence analysisAdd BLAST16
Compositional biasi1891 – 1921Polar residuesSequence analysisAdd BLAST31
Compositional biasi1924 – 1939Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1989 – 2019Polar residuesSequence analysisAdd BLAST31
Compositional biasi2029 – 2070Polar residuesSequence analysisAdd BLAST42
Compositional biasi2134 – 2158Polar residuesSequence analysisAdd BLAST25

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0644, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183107

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q921C3

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAMYQHI

Database of Orthologous Groups

More...
OrthoDBi
240778at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 2 hits
PF00400, WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 2 hits
SM00320, WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 2 hits
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 2 hits
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q921C3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPSPARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK
60 70 80 90 100
RLDWEGNEHN RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEVPPSISRV
110 120 130 140 150
TSLLGAGRQS LLRTAKDCRH TVWKGSAFAA LHRGRPPEMP VNYGPPPSLV
160 170 180 190 200
EIHRGRQLTG CSTFSTAFPG TMYQHIKMHR RILGHLSAVY CVAFDRTGHR
210 220 230 240 250
IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN TLIAAGSCDK
260 270 280 290 300
IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGPQRYMV STGADGTVCF
310 320 330 340 350
WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM
360 370 380 390 400
YFLGFDAPEK IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL
410 420 430 440 450
EWRSILLDMS ARISGDTSSE EERFMKPKVT MIAWNQDDST VVTAVNDHVL
460 470 480 490 500
KVWSSYTGQL LHNLLGHADE VFVLETHPFD SRIMLSAGHD GSIFIWDITK
510 520 530 540 550
GIKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL LIFGFGCSKP
560 570 580 590 600
YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH
610 620 630 640 650
PTKFQRLVPG RENSADEHLV PQLGYVATSD GEVIEQIISL HTNDSGDASP
660 670 680 690 700
ESSVLDGMIR QLQQQQDQRL GVDQDGTANG LPSGEGTPRR GSFRRLSLDI
710 720 730 740 750
QSPPNIGLRR SGQVEGVRQM HQNAPRSQIA TERDLQAWKR RVVVPEAPPG
760 770 780 790 800
MFRRLEDIRI ERGEEERNLY VIGRKKKTFQ VPQKSNSMVL VSQSRQRTCR
810 820 830 840 850
RKYANYSRRN ADQCELSSGN ESSGSVRHET SYDQSEGSCS SEDDEWRNDR
860 870 880 890 900
RSGSDSDSSS DSSSQYSDWT ADTGINLQPP LRMSCRRRVT RFCSTSEDEM
910 920 930 940 950
SMENISPPKR RRKRRKESKP KRESLRRMTP AELANMEHLY EFHPPVWITD
960 970 980 990 1000
TTLRKSPFVP QMGDEVMYFR QGHEAYIEAV RRNNIYELNP HKEPWRKMDL
1010 1020 1030 1040 1050
RDQELVKIVG LRYEVGPPTL CCLKLAFIDP ATGRLTDKSF SIRYHDMPDV
1060 1070 1080 1090 1100
IDFLVLRQFY DEARQRNWQP CDRFRSIIDD AWWFGTVLSQ EPYQPQYPDS
1110 1120 1130 1140 1150
HFQCYIVRWD NTETEKLSPW DMEPIPDNVD PPEELGASIS VTSDELEKLL
1160 1170 1180 1190 1200
YKPQEGEWGQ RSRDEECDRI ISGIDQLLNL DIAAAFAGPV DLCTYPKYCT
1210 1220 1230 1240 1250
VVAYPTDLYT IRMRLVNRFY RRLSALIWEV RYIEHNARTF NEPESVIARS
1260 1270 1280 1290 1300
AKKITDQLLK FIKNQDCTNI SELCNTSDND EDDSADDLDD SDLPKTSSGR
1310 1320 1330 1340 1350
RKVHNWKRRS RASGCIESDW RRQCKALLIL IFQCEDSEPF RQPVDLDEYP
1360 1370 1380 1390 1400
DYRDIIDTPM DFGTVRETLE AGNYDSPVEF CKDIRLIFSN AKAYTPNKRS
1410 1420 1430 1440 1450
KIYSMTLRLS ALFEEKMKKI SFDFKIGQKF KEKLRRSQRF KQRQNCNGAV
1460 1470 1480 1490 1500
PGDRRRRNVK QKQFKSQTKV IPQLMCPPSQ STSSKVPLSA TRKTSAGVSS
1510 1520 1530 1540 1550
GFTSGDSSDS AGSLERVRRQ RPEVLRSGSV LFGSEMEDFL ATSSSSSASN
1560 1570 1580 1590 1600
SSEESKASPG ARESSLRSGV LRGSNLGVTR TRAARRKAGS VSLENGCGRK
1610 1620 1630 1640 1650
ATRKRVYLSD SDNNSVETDE NLKNRKCGSS RKVLRKCAAV AASKIKLMSD
1660 1670 1680 1690 1700
AEDSSSESPC SGRKLPHRNA SAVARKKLLH NSDDQSLKSE TEELKDQNQS
1710 1720 1730 1740 1750
LLISGPHSVH NSISDSESDS DLRATRKTWN ANGCTSHTAA TCKTKSRPIE
1760 1770 1780 1790 1800
SSEEDSRCHG SDHGPSSTGD PSTSGQKLRA DSISEEADSE PESSVLCKNT
1810 1820 1830 1840 1850
HLCKKAKILS DSEDCEEKCG ERRGPEVEGS PVSEALREAI LAPQCLSHRG
1860 1870 1880 1890 1900
SETDVDSDGG AVREKSYSNE NGSVSLENGQ RRKVSRKSSS DKESNLQVTQ
1910 1920 1930 1940 1950
KSPKDRSSPS RITQRASVAT DKMKLTSDAE DLSLESVCTR SKRRRKKPAR
1960 1970 1980 1990 2000
FACTPAKTAL SSEEKHAHCE VPEAQPACRN KLPEPEHQDS AENPSQAASA
2010 2020 2030 2040 2050
DLNSGGGSSF EQRKSIQSRQ MGAVCVRPPP KTQSSSAGLS QENARSQTLD
2060 2070 2080 2090 2100
SETSLPSESV LTQKATVESN FEEELNYGLR RWNGRRLRTY GKAPLSRTAQ
2110 2120 2130 2140 2150
VTPSLQASAE VGVKRRRMHP EVDGEDVPGQ MGSSGCGPDT SPKASDLGSV
2160 2170 2180 2190 2200
TDSDVDCTDN TQTQRKKKRK GKARVLSKES VRKDREPHTK MRPCMLNEKD
2210 2220 2230 2240 2250
AVQMHSDTLK AKTVPEKVPR RCATVAANKI KMMCNLKEVV SGPENVGIRT
2260 2270 2280 2290 2300
ISRKLPYRQA SAAAKKKLLS VYKEDDAPIH SENEKELYLR RFRSRKEKAQ

PTPR
Length:2,304
Mass (Da):259,228
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC86E1A680C1060E
GO
Isoform B (identifier: Q921C3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2179-2294: ESVRKDREPH...KELYLRRFRS → GKPSSSNSPK...LELTDRTLRP
     2295-2304: Missing.

Show »
Length:2,259
Mass (Da):253,957
Checksum:i307FBDC8266D4B58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2W4E0A0A3B2W4E0_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WB25A0A3B2WB25_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
410Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WB00A0A3B2WB00_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
377Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WB73A0A3B2WB73_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W889A0A3B2W889_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BPZ1Q8BPZ1_MOUSE
Bromodomain and WD repeat-containin...
Brwd1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97 – 103ISRVTSL → KERGTSR in CAC44373 (Ref. 1) Curated7
Sequence conflicti97 – 103ISRVTSL → KERGTSR in CAC44374 (Ref. 1) Curated7
Sequence conflicti251I → V in CAC44373 (Ref. 1) Curated1
Sequence conflicti251I → V in CAC44374 (Ref. 1) Curated1
Sequence conflicti967M → I in CAC44373 (Ref. 1) Curated1
Sequence conflicti967M → I in CAC44374 (Ref. 1) Curated1
Sequence conflicti970R → P in CAC44373 (Ref. 1) Curated1
Sequence conflicti970R → P in CAC44374 (Ref. 1) Curated1
Sequence conflicti996R → G in CAC44373 (Ref. 1) Curated1
Sequence conflicti996R → G in CAC44374 (Ref. 1) Curated1
Sequence conflicti1021C → L in CAC44373 (Ref. 1) Curated1
Sequence conflicti1021C → L in CAC44374 (Ref. 1) Curated1
Sequence conflicti1053F → L in CAC44373 (Ref. 1) Curated1
Sequence conflicti1053F → L in CAC44374 (Ref. 1) Curated1
Sequence conflicti1058Q → P in CAC44373 (Ref. 1) Curated1
Sequence conflicti1058Q → P in CAC44374 (Ref. 1) Curated1
Sequence conflicti1091E → D in CAC44373 (Ref. 1) Curated1
Sequence conflicti1091E → D in CAC44374 (Ref. 1) Curated1
Sequence conflicti1133E → K in CAC44373 (Ref. 1) Curated1
Sequence conflicti1133E → K in CAC44374 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0185522179 – 2294ESVRK…RRFRS → GKPSSSNSPKTARHPRQSKG PRLNVDDNDWEDLDYAKAKG VVRLSKIQTRNQGRRTVRYH DGEDDRSIESALELTDRTLR P in isoform B. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_0185532295 – 2304Missing in isoform B. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ292467 mRNA Translation: CAC44373.1
AJ292468 mRNA Translation: CAC44374.1
AC144797 Genomic DNA No translation available.
AC152502 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS49923.1 [Q921C3-1]

NCBI Reference Sequences

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RefSeqi
NP_001096649.1, NM_001103179.1 [Q921C3-2]
NP_660107.2, NM_145125.3 [Q921C3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023631; ENSMUSP00000023631; ENSMUSG00000022914 [Q921C3-1]
ENSMUST00000099502; ENSMUSP00000097101; ENSMUSG00000022914 [Q921C3-1]
ENSMUST00000232755; ENSMUSP00000156497; ENSMUSG00000022914 [Q921C3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
93871

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:93871

UCSC genome browser

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UCSCi
uc008aci.2, mouse [Q921C3-1]
uc008ack.2, mouse [Q921C3-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292467 mRNA Translation: CAC44373.1
AJ292468 mRNA Translation: CAC44374.1
AC144797 Genomic DNA No translation available.
AC152502 Genomic DNA No translation available.
CCDSiCCDS49923.1 [Q921C3-1]
RefSeqiNP_001096649.1, NM_001103179.1 [Q921C3-2]
NP_660107.2, NM_145125.3 [Q921C3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi220337, 2 interactors
IntActiQ921C3, 2 interactors
STRINGi10090.ENSMUSP00000023631

PTM databases

iPTMnetiQ921C3
PhosphoSitePlusiQ921C3

Proteomic databases

jPOSTiQ921C3
PaxDbiQ921C3
PRIDEiQ921C3
ProteomicsDBi265240 [Q921C3-1]
265241 [Q921C3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23299, 96 antibodies

The DNASU plasmid repository

More...
DNASUi
93871

Genome annotation databases

EnsembliENSMUST00000023631; ENSMUSP00000023631; ENSMUSG00000022914 [Q921C3-1]
ENSMUST00000099502; ENSMUSP00000097101; ENSMUSG00000022914 [Q921C3-1]
ENSMUST00000232755; ENSMUSP00000156497; ENSMUSG00000022914 [Q921C3-2]
GeneIDi93871
KEGGimmu:93871
UCSCiuc008aci.2, mouse [Q921C3-1]
uc008ack.2, mouse [Q921C3-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54014
MGIiMGI:1890651, Brwd1

Phylogenomic databases

eggNOGiKOG0644, Eukaryota
GeneTreeiENSGT00950000183107
InParanoidiQ921C3
OMAiGAMYQHI
OrthoDBi240778at2759
TreeFamiTF324197

Enzyme and pathway databases

ReactomeiR-MMU-1266695, Interleukin-7 signaling
R-MMU-3247509, Chromatin modifying enzymes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
93871, 0 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Brwd1, mouse

Protein Ontology

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PROi
PR:Q921C3
RNActiQ921C3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022914, Expressed in secondary oocyte and 332 other tissues
ExpressionAtlasiQ921C3, baseline and differential
GenevisibleiQ921C3, MM

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439, Bromodomain, 2 hits
PF00400, WD40, 5 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SM00320, WD40, 8 hits
SUPFAMiSSF47370, SSF47370, 2 hits
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 2 hits
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 6 hits
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRWD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q921C3
Secondary accession number(s): E9QAC1, Q921C2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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