UniProtKB - Q921C1 (CXG3_MOUSE)
Protein
Gap junction gamma-3 protein
Gene
Gjc3
Organism
Mus musculus (Mouse)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity
Caution
It is uncertain whether Met-1 or Met-12 is the initiator.Curated
GO - Molecular functioni
- gap junction channel activity Source: MGI
GO - Biological processi
- cell-cell signaling Source: MGI
- myelination Source: MGI
- sensory perception of sound Source: MGI
Protein family/group databases
TCDBi | 1.A.24.1.12, the gap junction-forming connexin (connexin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction gamma-3 proteinAlternative name(s): Connexin-29 Short name: Cx29 Gap junction epsilon-1 protein |
Gene namesi | Name:Gjc3 Synonyms:Cx29, Gje1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2153041, Gjc3 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- gap junction By similarity
Plasma Membrane
- connexin complex Source: GO_Central
Other locations
- gap junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
- myelin sheath Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 86 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 145 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 167 – 205 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 269 | ExtracellularSequence analysisAdd BLAST | 43 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000354706 | 1 – 269 | Gap junction gamma-3 proteinAdd BLAST | 269 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 261 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q921C1 |
PaxDbi | Q921C1 |
PeptideAtlasi | Q921C1 |
PRIDEi | Q921C1 |
PTM databases
iPTMneti | Q921C1 |
PhosphoSitePlusi | Q921C1 |
SwissPalmi | Q921C1 |
Expressioni
Tissue specificityi
CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.
Gene expression databases
Bgeei | ENSMUSG00000056966, Expressed in lumbar subsegment of spinal cord and 86 other tissues |
Genevisiblei | Q921C1, MM |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076367 |
Miscellaneous databases
RNActi | Q921C1, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVY2, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | Q921C1 |
OMAi | CYDAFHP |
OrthoDBi | 1092887at2759 |
PhylomeDBi | Q921C1 |
TreeFami | TF329606 |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q921C1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS
60 70 80 90 100
GPGVFGNDEN EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA
110 120 130 140 150
IYVAFTLYHV IGYWEVPGKE NKEQETQISK GDHSKDVSGA KSLKLLWAYV
160 170 180 190 200
AHLGVRLALE GAALGVQYNL YGFKMSSTFI CREDPCIGST TCFQSHPSEK
210 220 230 240 250
TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF LKKLPTSESS
260
VRSKDTTDEL SVVEAKEPF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY823670 Genomic DNA Translation: AAX39497.1 AY289210 mRNA Translation: AAP41202.1 AY293564 mRNA Translation: AAP50246.1 AY297108 mRNA Translation: AAP51160.1 AK034037 mRNA Translation: BAC28554.1 AK045577 mRNA Translation: BAC32421.1 AK047368 mRNA Translation: BAC33038.1 AK147913 mRNA Translation: BAE28224.1 CH466529 Genomic DNA Translation: EDL19225.1 CH466529 Genomic DNA Translation: EDL19226.1 BC125305 mRNA Translation: AAI25306.1 AJ297318 Genomic DNA Translation: CAC29245.1 AF503616 Genomic DNA Translation: AAM21146.1 |
CCDSi | CCDS19782.1 |
RefSeqi | NP_536698.2, NM_080450.4 |
Genome annotation databases
Ensembli | ENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966 |
GeneIDi | 118446 |
KEGGi | mmu:118446 |
UCSCi | uc009aeg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY823670 Genomic DNA Translation: AAX39497.1 AY289210 mRNA Translation: AAP41202.1 AY293564 mRNA Translation: AAP50246.1 AY297108 mRNA Translation: AAP51160.1 AK034037 mRNA Translation: BAC28554.1 AK045577 mRNA Translation: BAC32421.1 AK047368 mRNA Translation: BAC33038.1 AK147913 mRNA Translation: BAE28224.1 CH466529 Genomic DNA Translation: EDL19225.1 CH466529 Genomic DNA Translation: EDL19226.1 BC125305 mRNA Translation: AAI25306.1 AJ297318 Genomic DNA Translation: CAC29245.1 AF503616 Genomic DNA Translation: AAM21146.1 |
CCDSi | CCDS19782.1 |
RefSeqi | NP_536698.2, NM_080450.4 |
3D structure databases
SMRi | Q921C1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076367 |
Protein family/group databases
TCDBi | 1.A.24.1.12, the gap junction-forming connexin (connexin) family |
PTM databases
iPTMneti | Q921C1 |
PhosphoSitePlusi | Q921C1 |
SwissPalmi | Q921C1 |
Proteomic databases
MaxQBi | Q921C1 |
PaxDbi | Q921C1 |
PeptideAtlasi | Q921C1 |
PRIDEi | Q921C1 |
Protocols and materials databases
Antibodypediai | 3109, 173 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966 |
GeneIDi | 118446 |
KEGGi | mmu:118446 |
UCSCi | uc009aeg.1, mouse |
Organism-specific databases
CTDi | 349149 |
MGIi | MGI:2153041, Gjc3 |
Phylogenomic databases
eggNOGi | ENOG502QVY2, Eukaryota |
GeneTreei | ENSGT00970000193389 |
HOGENOMi | CLU_037388_4_0_1 |
InParanoidi | Q921C1 |
OMAi | CYDAFHP |
OrthoDBi | 1092887at2759 |
PhylomeDBi | Q921C1 |
TreeFami | TF329606 |
Miscellaneous databases
BioGRID-ORCSi | 118446, 0 hits in 17 CRISPR screens |
ChiTaRSi | Gjc3, mouse |
PROi | PR:Q921C1 |
RNActi | Q921C1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056966, Expressed in lumbar subsegment of spinal cord and 86 other tissues |
Genevisiblei | Q921C1, MM |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXG3_MOUSE | |
Accessioni | Q921C1Primary (citable) accession number: Q921C1 Secondary accession number(s): Q53ZP5, Q8BHJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2003 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families