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Protein

Neurotrophin receptor-interacting factor 2

Gene

Nrif2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity).By similarity

Miscellaneous

Up-regulated in Nrif1 mutant mice in the 129/Sv background, possibly complementating for the absence of Nrif1 and explaining why Nrif1 mutant mice are viable in a 129/Sv background, whilke they are lethal in other backgrounds.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri680 – 702C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri792 – 814C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • regulation of cell cycle Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin receptor-interacting factor 2
Alternative name(s):
Zinc finger protein 369
Gene namesi
Name:Nrif2
Synonyms:Zfp369
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2176229 Zfp369

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069671 – 824Neurotrophin receptor-interacting factor 2Add BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ921B4
PRIDEiQ921B4

PTM databases

iPTMnetiQ921B4
PhosphoSitePlusiQ921B4

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Interactioni

Subunit structurei

Interacts with NGFR/p75(NTR).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119114

Structurei

3D structure databases

ProteinModelPortaliQ921B4
SMRiQ921B4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini161 – 243SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini279 – 359KRAB 2PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri680 – 702C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri736 – 758C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri764 – 786C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri792 – 814C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234619
HOVERGENiHBG054183
InParanoidiQ921B4
PhylomeDBiQ921B4

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q921B4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASTLPTTWP HESVKFEDVS LRFTEEEWAL LDRQQKCLYR EIMMENLNNM
60 70 80 90 100
ISVEHHFSKA NVMPQLEEVE DCWPMQREIP QDTLPECSGH SLDPEMNSFP
110 120 130 140 150
AESPLMKIKV VEVLTLNKDM AGPRNALIQS LYPESGEDLN PGNLKPAQQP
160 170 180 190 200
SKHLTDTEAS RQKFRHFQYE ESAGPQKSVS QLRKLCHQWL QPSTRSKKQI
210 220 230 240 250
LELLVLEQFL NALPEKLRVW VESQHPEDCK AVVALLENMT SVSKDDAWLA
260 270 280 290 300
CSSEATDELK EKRKDVATLP VTVPPEAPVT FQDVAVDFSQ EEWQLLGPMQ
310 320 330 340 350
RTKYHDVMLE TLGNLVSVGW EPTLGNRELT PDSPIPVVKP IHDPNPKDLS
360 370 380 390 400
RNRTQSTLFE SISPDEVQGR HTIESNPVGL LQEKGHPQQK LSESSKSQNQ
410 420 430 440 450
TCIDKSQCSL NEVLPRNHVK VKQKGTGKGK GRTNTISMTG GLRIRNQQKD
460 470 480 490 500
SVEWRDRSGS TPVTHGSSIK NQQLGSEQGK TQTSRDPITL TVPAEFYQEA
510 520 530 540 550
TGSEEGRFRN SSNAMAADAP PKIHQKGPEW HKAGKSNNSM LQGSSAQNHQ
560 570 580 590 600
MGSRAGRARD NSILTHVKIH QKGYKEGKIQ GNNNYLKHVK PHRKGSKEER
610 620 630 640 650
LRELSTCQKH VPYVKQHLKT SGRGKGRKIN ASIKCGPYIK TYYRGSDVGR
660 670 680 690 700
LRRANNCRKA ISRHAQQISF IKIHKGSQVC QCSECGKMFR NARYFSVHKK
710 720 730 740 750
IHTGERPYMC MSCGKAFVQS SSLTQHLRIH SGERPFECSE CGRTFSDRSA
760 770 780 790 800
ASQHLRTHTG AKPYQCQHCG KAFRQSSHLT RHVRIHTGER PYVCTKCGKA
810 820
FTQSSNLIGH QKTHRKKFKK QPKL
Length:824
Mass (Da):93,244
Last modified:December 1, 2001 - v1
Checksum:i2BC3BAF6FAF233DB
GO
Isoform 2 (identifier: Q921B4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-361: GWEPTLGNRE...NRTQSTLFES → ALGQVHVEDG...GTRPSAILWS
     362-824: Missing.

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):40,856
Checksum:i1475BC04C14B4E67
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQL6F8VQL6_MOUSE
Zinc finger protein 369
Zfp369
845Annotation score:
E9Q628E9Q628_MOUSE
Zinc finger protein 369
Zfp369
382Annotation score:
D3Z1J4D3Z1J4_MOUSE
Zinc finger protein 369
Zfp369
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42I → V in BAC39159 (PubMed:16141072).Curated1
Sequence conflicti491T → A in BAC39159 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040912319 – 361GWEPT…TLFES → ALGQVHVEDGGAGPNRNGSQ PLVRRSSFIPLPAGTRPSAI LWS in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_040913362 – 824Missing in isoform 2. 1 PublicationAdd BLAST463

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ319726 mRNA Translation: CAC41280.1
BC036565 mRNA Translation: AAH36565.1
AK084309 mRNA Translation: BAC39159.1
UniGeneiMm.151546

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ319726 mRNA Translation: CAC41280.1
BC036565 mRNA Translation: AAH36565.1
AK084309 mRNA Translation: BAC39159.1
UniGeneiMm.151546

3D structure databases

ProteinModelPortaliQ921B4
SMRiQ921B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119114

PTM databases

iPTMnetiQ921B4
PhosphoSitePlusiQ921B4

Proteomic databases

PaxDbiQ921B4
PRIDEiQ921B4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2176229 Zfp369

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234619
HOVERGENiHBG054183
InParanoidiQ921B4
PhylomeDBiQ921B4

Miscellaneous databases

PROiPR:Q921B4
SOURCEiSearch...

Family and domain databases

CDDicd07765 KRAB_A-box, 2 hits
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 2 hits
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00349 KRAB, 2 hits
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 2 hits
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 2 hits
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNRIF2_MOUSE
AccessioniPrimary (citable) accession number: Q921B4
Secondary accession number(s): Q8BJF0, Q8K1Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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