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Protein

Alpha-2,8-sialyltransferase 8B

Gene

ST8SIA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei185SubstrateBy similarity1
Active sitei346Proton donor/acceptorBy similarity1

GO - Molecular functioni

  • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: BHF-UCL
  • sialic acid binding Source: BHF-UCL

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • cellular protein modification process Source: ProtInc
  • ganglioside biosynthetic process Source: BHF-UCL
  • nervous system development Source: ProtInc
  • N-glycan processing Source: BHF-UCL
  • oligosaccharide metabolic process Source: BHF-UCL
  • protein glycosylation Source: BHF-UCL

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-4085001 Sialic acid metabolism
R-HSA-419037 NCAM1 interactions
R-HSA-975577 N-Glycan antennae elongation
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2,8-sialyltransferase 8B (EC:2.4.99.-)
Alternative name(s):
Sialyltransferase 8B
Short name:
SIAT8-B
Sialyltransferase St8Sia II
Short name:
ST8SiaII
Sialyltransferase X
Short name:
STX
Gene namesi
Name:ST8SIA2
Synonyms:SIAT8B, STX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140557.11
HGNCiHGNC:10870 ST8SIA2
MIMi602546 gene
neXtProtiNX_Q92186

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini24 – 375LumenalSequence analysisAdd BLAST352

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8128
OpenTargetsiENSG00000140557
PharmGKBiPA35771

Polymorphism and mutation databases

BioMutaiST8SIA2
DMDMi2494831

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492851 – 375Alpha-2,8-sialyltransferase 8BAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 307By similarity
Disulfide bondi171 ↔ 371By similarity
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92186
PeptideAtlasiQ92186
PRIDEiQ92186
ProteomicsDBi75253

PTM databases

iPTMnetiQ92186
PhosphoSitePlusiQ92186

Expressioni

Tissue specificityi

Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.

Gene expression databases

BgeeiENSG00000140557
CleanExiHS_ST8SIA2
ExpressionAtlasiQ92186 baseline and differential
GenevisibleiQ92186 HS

Organism-specific databases

HPAiHPA054518

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000268164

Structurei

3D structure databases

ProteinModelPortaliQ92186
SMRiQ92186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni206 – 208Substrate bindingBy similarity3
Regioni294 – 296Substrate bindingBy similarity3
Regioni329 – 330Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074407
HOGENOMiHOG000232070
HOVERGENiHBG056466
InParanoidiQ92186
KOiK06612
OMAiFWPFPLD
OrthoDBiEOG091G0AL4
PhylomeDBiQ92186
TreeFamiTF352820

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q92186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS
60 70 80 90 100
KSNRAEVVIN GSSSPAVVDR SNESIKHNIQ PASSKWRHNQ TLSLRIRKQI
110 120 130 140 150
LKFLDAEKDI SVLKGTLKPG DIIHYIFDRD STMNVSQNLY ELLPRTSPLK
160 170 180 190 200
NKHFGTCAIV GNSGVLLNSG CGQEIDAHSF VIRCNLAPVQ EYARDVGLKT
210 220 230 240 250
DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HSLNGSILWI PAFMARGGKE
260 270 280 290 300
RVEWVNELIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY
310 320 330 340 350
TLATRFCKQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL
360 370
EFKALKSLHE QGALKLTVGQ CDGAT
Length:375
Mass (Da):42,430
Last modified:February 1, 1997 - v1
Checksum:i42F0BC5B33D62325
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155G → Q in AAA36613 (PubMed:9054414).Curated1
Sequence conflicti171C → Y in AAA36613 (PubMed:9054414).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33551 mRNA Translation: AAC24458.1
U82762 mRNA Translation: AAB51242.1
BC069584 mRNA Translation: AAH69584.1
BC096203 mRNA Translation: AAH96203.1
BC096204 mRNA Translation: AAH96204.1
L29556 mRNA Translation: AAA36613.1
CCDSiCCDS10372.1
PIRiB54898
I39169
RefSeqiNP_006002.1, NM_006011.3
UniGeneiHs.302341

Genome annotation databases

EnsembliENST00000268164; ENSP00000268164; ENSG00000140557
GeneIDi8128
KEGGihsa:8128
UCSCiuc002bra.4 human

Similar proteinsi

Entry informationi

Entry nameiSIA8B_HUMAN
AccessioniPrimary (citable) accession number: Q92186
Secondary accession number(s): Q4VAZ0, Q92470, Q92746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

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