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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

Gene

ST6GALNAC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.1 Publication

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei186CMP-N-acetylneuraminateBy similarity1
Binding sitei209CMP-N-acetylneuraminateBy similarity1
Binding sitei334CMP-N-acetylneuraminateBy similarity1
Binding sitei366CMP-N-acetylneuraminateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC:2.4.99.31 Publication)
Alternative name(s):
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase
GalNAc alpha-2,6-sialyltransferase II
ST6GalNAc II
Short name:
ST6GalNAcII
Sialyltransferase 7B
Short name:
SIAT7-B
Gene namesi
Name:ST6GALNAC2
Synonyms:SIAT7B
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini26 – 404LumenalSequence analysisAdd BLAST379

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492741 – 404Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 178By similarity
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 347By similarity
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92184

Expressioni

Tissue specificityi

Heart, kidney, testes, brain, liver and lung.

Developmental stagei

Abundantly expressed at all embryonic stages but not present in adult tissues.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002914

Structurei

3D structure databases

SMRiQ92184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
HOGENOMiHOG000231097
HOVERGENiHBG056467
InParanoidiQ92184
KOiK06616
PhylomeDBiQ92184

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q92184-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPRWKRFC FLLLAAFTSS LLLYGHYYAT VDVRSGPRVV TSLLQPELLF
60 70 80 90 100
LVRPDTPHPD NSHHKELRGT VKSREFFSQP SSELEKPKPS GKQPTPCPRS
110 120 130 140 150
VAATAKADPT FGELFQFDIP VLMWDQHFNP ETWDRLKARR VPYGWQGLSQ
160 170 180 190 200
AAVGSTLRLL NTSSNTRLFD RHLFPGGCIR CAVVGNGGIL NGSRQGRAID
210 220 230 240 250
AHDLVFRLNG AITKGFEEDV GSKVSFYGFT VNTMKNSLIA YEAYGFTRTP
260 270 280 290 300
QGKDLKYIFI PSDARDYIML RSAIQGSPVP EGLDKGDEPQ KYFGLEASAE
310 320 330 340 350
KFKLLHPDFL HYLTTRFLRS ELLDMQYGHL YMPSTGALML LTALHTCDQV
360 370 380 390 400
SAYGFITANY EQFSDHYYEP EKKPLVFYAN HDMLLEAELW RSLHRAGIME

LYQR
Length:404
Mass (Da):45,826
Last modified:November 1, 1997 - v1
Checksum:iDCC177AA01ABB60A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77775 mRNA Translation: CAA54813.1
PIRiA54871
RefSeqiNP_990564.1, NM_205233.1
UniGeneiGga.39684

Genome annotation databases

GeneIDi396159
KEGGigga:396159

Similar proteinsi

Entry informationi

Entry nameiSIA7B_CHICK
AccessioniPrimary (citable) accession number: Q92184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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