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UniProtKB - Q92123 (AT1A1_XENLA)
Protein
Sodium/potassium-transporting ATPase subunit alpha-1
Gene
atp1a1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
By similarityCatalytic activityi
- EC:7.2.2.13
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 378 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Binding sitei | 489 | ATPBy similarity | 1 | |
Metal bindingi | 719 | MagnesiumBy similarity | 1 | |
Metal bindingi | 723 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- P-type sodium:potassium-exchanging transporter activity Source: BHF-UCL
GO - Biological processi
- cellular potassium ion homeostasis Source: BHF-UCL
- cellular sodium ion homeostasis Source: BHF-UCL
- membrane repolarization Source: BHF-UCL
- potassium ion import across plasma membrane Source: BHF-UCL
- sodium ion export across plasma membrane Source: BHF-UCL
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit alpha-1 (EC:7.2.2.13)Short name: Na(+)/K(+) ATPase alpha-1 subunit Alternative name(s): Sodium pump subunit alpha-1 |
Gene namesi | Name:atp1a1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6254180, atp1a1.L |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB-SubCell
- sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 89 | CytoplasmicSequence analysisAdd BLAST | 89 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 133 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 155 – 290 | CytoplasmicSequence analysisAdd BLAST | 136 | |
Transmembranei | 291 – 310 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 311 – 322 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 323 – 340 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 341 – 774 | CytoplasmicSequence analysisAdd BLAST | 434 | |
Transmembranei | 775 – 794 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 795 – 804 | ExtracellularSequence analysis | 10 | |
Transmembranei | 805 – 825 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 826 – 845 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 846 – 868 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 869 – 920 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 921 – 940 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 941 – 953 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 954 – 972 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 973 – 987 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 988 – 1008 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1009 – 1025 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046296 | 1 – 1025 | Sodium/potassium-transporting ATPase subunit alpha-1Add BLAST | 1025 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 945 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
CuratedFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 84 – 86 | Interaction with phosphoinositide-3 kinaseBy similarity | 3 | |
Regioni | 216 – 237 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 37 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q92123-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGYGAGRDKY EPAATSEQGG KKKKGKGKGK EKDMDELKKE VTMEDHKLSL
60 70 80 90 100
DELHRKFGTD MQRGLTTARA AEILARDGPN ALTPPPTTPE WVKFCRQLFG
110 120 130 140 150
GFSMLLWIGA ILCFLAYGIQ AAMEEEPQND NLYLGVVLSA VVIITGCFSY
160 170 180 190 200
YQEAKSSKIM ESFKNMVPQQ ALVIRSGEKL SINAEEVVLG DLVEVKGGDR
210 220 230 240 250
IPADLRVISS HGCKVDNSSL TGESEPQTRS PDFTNENPLE TRNIAFFSTN
260 270 280 290 300
CVEGTARGIV VNTGDRTVMG RIATLASGLD GGRTPIAIEI EHFIHIITGV
310 320 330 340 350
AVFLGVSFFI LSLILQYTWL EAVIFLIGII VANVPEGLLA TVTVCLTLTA
360 370 380 390 400
KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH
410 420 430 440 450
EADTTENQSG ASFDKSSPTW TALSRVAGLC NRAVFQAGQE NTPILKRDVA
460 470 480 490 500
GDASESALLK CIELCCGSVR DMREKNHKVA EIPFNSTNKY QLSVHKNANP
510 520 530 540 550
SESRYILVMK GAPERILDRC TSIILQGKEQ PLDEELKDAF QNAYLELGGL
560 570 580 590 600
GERVLGFCHL ALPDDQFPDG FQFDTEEVNF PTENLCFVGL ISMIDPPRAA
610 620 630 640 650
VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL
660 670 680 690 700
NIPVNQVNPR DAKACVIHGT DLKDMTEEQI DDILRHHTEI VFARTSPQQK
710 720 730 740 750
LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGIAG SDVSKQAADM
760 770 780 790 800
ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLIFIIANI
810 820 830 840 850
PLPLGTVTIL CIDLGTDMVP AISLAYEQAE SDIMKRQPRN PKTDKLVNER
860 870 880 890 900
LISMAYGQIG MIQALGGFFT YFVILAENGF LPWTLLGIRV NWDDRWTNDV
910 920 930 940 950
EDSYGQQWTY EQRKIVEFTC HTSFFISIVV VQWADLIICK TRRNSVFQQG
960 970 980 990 1000
MKNKILIFGL FEETALAAFL SYCPGMDVAL RMYPLKPTWW FCAFPYSLII
1010 1020
FIYDEVRKLI IRRSPGGWVE KESYY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | K → Q in AAC59760 (PubMed:8631513).Curated | 1 | |
Sequence conflicti | 29 – 30 | Missing in AAC59759 (PubMed:8631513).Curated | 2 | |
Sequence conflicti | 29 – 30 | Missing in AAC59760 (PubMed:8631513).Curated | 2 | |
Sequence conflicti | 31 | E → D in AAC59760 (PubMed:8631513).Curated | 1 | |
Sequence conflicti | 61 – 63 | MQR → LQK in AAC59760 (PubMed:8631513).Curated | 3 | |
Sequence conflicti | 67 | T → S in AAC59760 (PubMed:8631513).Curated | 1 | |
Sequence conflicti | 81 | A → S in AAC59760 (PubMed:8631513).Curated | 1 | |
Sequence conflicti | 92 | V → G in AAC59760 (PubMed:8631513).Curated | 1 | |
Sequence conflicti | 102 | F → L in AAC59760 (PubMed:8631513).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10108 mRNA Translation: AAA19022.1 U49238 mRNA Translation: AAC59759.1 U49239 mRNA Translation: AAC59760.1 |
PIRi | A60444 |
RefSeqi | NP_001084064.1, NM_001090595.1 |
Genome annotation databases
GeneIDi | 399285 |
KEGGi | xla:399285 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10108 mRNA Translation: AAA19022.1 U49238 mRNA Translation: AAC59759.1 U49239 mRNA Translation: AAC59760.1 |
PIRi | A60444 |
RefSeqi | NP_001084064.1, NM_001090595.1 |
3D structure databases
SMRi | Q92123 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 399285 |
Genome annotation databases
GeneIDi | 399285 |
KEGGi | xla:399285 |
Organism-specific databases
CTDi | 399285 |
Xenbasei | XB-GENE-6254180, atp1a1.L |
Family and domain databases
CDDi | cd02608, P-type_ATPase_Na-K_like, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005775, P-type_ATPase_IIC IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01106, ATPase-IIC_X-K, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT1A1_XENLA | |
Accessioni | Q92123Primary (citable) accession number: Q92123 Secondary accession number(s): Q91683, Q92127 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |