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UniProtKB - Q92104 (CP11B_LITCT)
Protein
Cytochrome P450 11B, mitochondrial
Gene
CYP11B
Organism
Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Status
Functioni
Has 11 beta-hydroxylation, 18-hydroxylation activities and aldosterone synthetic activity. Catalyzes the final steps of glucocorticoid and mineralocorticoid biosynthesis.
Catalytic activityi
- a steroid + 2 H+ + O2 + 2 reduced [adrenodoxin] = an 11β-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]EC:1.14.15.4
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 465 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- steroid 11-beta-monooxygenase activity Source: UniProtKB-EC
GO - Biological processi
- steroid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Steroidogenesis |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 11B, mitochondrialAlternative name(s): |
Gene namesi | Name:CYP11B |
Organismi | Lithobates catesbeianus (American bullfrog) (Rana catesbeiana) |
Taxonomic identifieri | 8400 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Lithobates |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 45 | MitochondrionSequence analysisAdd BLAST | 45 | |
ChainiPRO_0000003607 | 46 – 517 | Cytochrome P450 11B, mitochondrialAdd BLAST | 472 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q92104-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLEKTAARQI GSCLMRCRTL DTTSPLWTGF SRLSTAPLIH EAREDGSLAS
60 70 80 90 100
QTLPYEAIPT TGRSAWFNLF QFWRKNSFQH MHLAMEENFQ NLGPIYREKL
110 120 130 140 150
GTHNSVNIML PQDVARLFQS EGIFPRRMTM EAWSKHRELR NHKQGVFLLN
160 170 180 190 200
GEAWRSDRII LNKEVLSLAG VKKFLPFLDE AAADFVTFMK KRMSKNTRGS
210 220 230 240 250
LTVDLYADLF RFTLEASSYV LYGQRLGLLE EHPNADTLRF ISAVETVLKT
260 270 280 290 300
TLPLLYYPHQ ILQLFQTRLW NEHMHAWDVI FEQADRCIQN IYQEYCLGQE
310 320 330 340 350
RGYSGIMAEL LLQAELPLDS IKANITELMA GGVDTTAMPL LFTLFELARN
360 370 380 390 400
PSVQRELREE IRKAEAQNPN DLNQLLNSLP LLKGAIKETL RLYPVGITVQ
410 420 430 440 450
RHLIKDIVLH NYHIPAGTLV QVGLYPMGRS PLLFQDALRY DPARWLKRED
460 470 480 490 500
TNFKALAFGF GSRQCIGRRI AETEITLFLM HMLKNFQIDT VSKDDIKTVF
510
GFILMPEKPP LLTFRPI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10984 mRNA Translation: BAA01756.1 |
PIRi | S69347 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10984 mRNA Translation: BAA01756.1 |
PIRi | S69347 |
3D structure databases
SMRi | Q92104 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP11B_LITCT | |
Accessioni | Q92104Primary (citable) accession number: Q92104 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 26, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |