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UniProtKB - Q92100 (CP1A1_PLEPL)
Protein
Cytochrome P450 1A1
Gene
cyp1a1
Organism
Pleuronectes platessa (European plaice)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 229 | SubstrateBy similarity | 1 | |
Metal bindingi | 463 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:cyp1a1 |
Organismi | Pleuronectes platessa (European plaice) |
Taxonomic identifieri | 8262 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Carangaria › Pleuronectiformes › Pleuronectoidei › Pleuronectidae › Pleuronectes |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051646 | 1 – 521 | Cytochrome P450 1A1Add BLAST | 521 |
Expressioni
Inductioni
By 3-methylcholanthrene (3MC) and isosafrole (ISF).
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008066, Cyt_P450_E_grp-I_CYP1 IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01683, EP450ICYP1A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q92100-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLMMLPFIG SVSVSESLVA MTTMCLVYLI LKFFQTEIPE GLRRLPGPKP
60 70 80 90 100
LPIIGNVLGL GSKPYLSLTA MSKRYGHVFQ IQIGMRPVVV LSGTGTVRQA
110 120 130 140 150
LIKQGDEFAG RPDLYSFRFI NAGKSLAFST DQAGVWRARR KLAYSALRSF
160 170 180 190 200
STLEGTTPEY SCVLEEHICK EGEYLIKQLN TVMKADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHDDQELV SLVTLSDEFG RVVGSGNPAD FIPILQYLPS
260 270 280 290 300
AEMKNFLRIN EHFTEFVQKI VTEHYTTFNK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNVQMSDE KIVGIVNDLF GAGFDTVSTA LSWSVMYLVA HPEIQERLYQ
360 370 380 390 400
EIEDKVGLDR MPLLSDKPNL PFLEAFILEI LRHSSFLPFT IPHCTTKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQIN HDPELWKDPS SFNPDRFLSA DGSEVNKLDG
460 470 480 490 500
EKVMAFGMGK RRCIGEVIAR NEVYLFLAII IQKLHFLPIP GEKLDMTPEY
510 520
GLTMKHKRCH LKATMRARNE H
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73631 mRNA Translation: CAA52010.1 |
PIRi | S34184 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X73631 mRNA Translation: CAA52010.1 |
PIRi | S34184 |
3D structure databases
SMRi | Q92100 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008066, Cyt_P450_E_grp-I_CYP1 IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01683, EP450ICYP1A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP1A1_PLEPL | |
Accessioni | Q92100Primary (citable) accession number: Q92100 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 11, 2019 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |