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Protein

Alsin

Gene

Als2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Alsin
Alternative name(s):
Amyotrophic lateral sclerosis 2 protein homolog
Gene namesi
Name:Als2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921268 Als2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809041 – 1651AlsinAdd BLAST1651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei459PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei504PhosphothreonineBy similarity1
Modified residuei527N6-acetyllysineCombined sources1
Modified residuei1329PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ920R0
PaxDbiQ920R0
PeptideAtlasiQ920R0
PRIDEiQ920R0

PTM databases

iPTMnetiQ920R0
PhosphoSitePlusiQ920R0

Expressioni

Gene expression databases

BgeeiENSMUSG00000026024 Expressed in 107 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ920R0 baseline and differential
GenevisibleiQ920R0 MM

Interactioni

Subunit structurei

Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216427, 4 interactors
STRINGi10090.ENSMUSP00000027178

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 108RCC1 1CuratedAdd BLAST50
Repeati109 – 167RCC1 2CuratedAdd BLAST59
Repeati169 – 218RCC1 3CuratedAdd BLAST50
Repeati519 – 570RCC1 4CuratedAdd BLAST52
Repeati572 – 621RCC1 5CuratedAdd BLAST50
Domaini684 – 879DHPROSITE-ProRule annotationAdd BLAST196
Domaini895 – 1001PHCuratedAdd BLAST107
Repeati1043 – 1065MORN 1Add BLAST23
Repeati1066 – 1088MORN 2Add BLAST23
Repeati1094 – 1116MORN 3Add BLAST23
Repeati1117 – 1139MORN 4Add BLAST23
Repeati1145 – 1167MORN 5Add BLAST23
Repeati1169 – 1191MORN 6Add BLAST23
Repeati1192 – 1214MORN 7Add BLAST23
Repeati1215 – 1238MORN 8Add BLAST24
Domaini1507 – 1651VPS9PROSITE-ProRule annotationAdd BLAST145

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297
HOGENOMiHOG000033908
HOVERGENiHBG037320
InParanoidiQ920R0
KOiK04575
OMAiATCFEVT
OrthoDBiEOG091G00CU
TreeFamiTF331793

Family and domain databases

Gene3Di1.20.1050.80, 1 hit
1.20.900.10, 1 hit
2.130.10.30, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF00415 RCC1, 4 hits
PF00621 RhoGEF, 1 hit
PF02204 VPS9, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00698 MORN, 8 hits
SUPFAMiSSF109993 SSF109993, 1 hit
SSF48065 SSF48065, 1 hit
SSF50985 SSF50985, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 4 hits
PS51205 VPS9, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q920R0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKKKSSTE AEGSKERGLV HVWQAGSFSL TPERLPGWGG KTVLQAALGV
60 70 80 90 100
RHGVLLTEDG EVYSFGTLPW KSESAEICPS SPLLESALVG HHVITVATGS
110 120 130 140 150
FHSGAVTESG VVYMWGENAA GQCAVANQQY VPEPSPVSIS DSETSPSLAV
160 170 180 190 200
RILQLACGEE HTLALSLSRE IWAWGTGCQL GLITTTFPVT KPQKVEHLAG
210 220 230 240 250
RVVLQVACGA FHSLALVQCL PPQDLKPVPE RCNQCSQLLI TMTDKEDHVI
260 270 280 290 300
ISDSHCCPLG VTLSESQAEK HASPAPSPHP EALDEQGEVF ENTVVEAELN
310 320 330 340 350
MGSSQTTSGS AISTQQNVVG TAEVSSARTA PSYPDTHAVT AYLQKLSEHS
360 370 380 390 400
MRENHEPGEK PPQVQPLVEE AVPDLHSPPT TSTSALNSLV VSCASAVGVR
410 420 430 440 450
VAATYEAGAL SLKKVMNFYS TAPCETAAQS GSASTGPESL KDLREEQVKQ
460 470 480 490 500
ESLQGKKSSS LMDIREEELE GGSRRLSLPG LLSQVSPRLL RKAARVKTRT
510 520 530 540 550
VVLTPTYSGE ADALLPSLRT EVWTWGKGKE GQLGHGDVLP RLQPLCVKCL
560 570 580 590 600
DGKEVIHLEA GGSHSLALTA KSQVYSWGSN TFGQLGHSEF PTTVPRLSKV
610 620 630 640 650
SSENGVWSVA AGQDYSLFLV DTEDFQPGLY YSGRQDRAEG DTLPENPSGT
660 670 680 690 700
KTPVLLSCSK LGYISRVTAG KDSYLALVDK NIMGYIASLH ELASTERRFY
710 720 730 740 750
SKLSEIKSQI LRPLLSLENL GTVTTVQLLQ EVASRFSKLC YLIGQHGASL
760 770 780 790 800
SSYLQGMKEA SSLVIMKHSS LFLDSYTEYC TSVSNFLVMG GFQLLAKPAI
810 820 830 840 850
DFLNKNQELL QDLSEVNDEN TQLMEILNML FFLPIRRLHN YAKVLLKLAT
860 870 880 890 900
CFEVTSPEYQ KLQDSSSCYE SLALHLGKKR KEAEYTLSFW KTFPGKMTDS
910 920 930 940 950
LRKPERRLLC ESSNRALSLQ HAGRFSVNWF ILFNDALVHA QFSTHHVFPL
960 970 980 990 1000
ATLWAEPLSE EAGSVNGLKI TTPEEQFTLI SSTPQEKTKW LRAISQAVDQ
1010 1020 1030 1040 1050
ALRGTSDFPL YGGGSSVQRQ EPPISRSAKY TFYKDTRLKD ATYDGRWLSG
1060 1070 1080 1090 1100
KPHGRGVLKW PDGKMYSGMF RNGLEDGYGE YRIPNKALNK EDHYVGHWKE
1110 1120 1130 1140 1150
GKMCGQGVYS YASGEVFEGC FQDNMRHGHG LLRSGKLTSS SPSMFIGQWV
1160 1170 1180 1190 1200
MDKKAGYGVF DDITRGEKYM GMWQDDVCQG NGVVVTQFGL YYEGNFHLNK
1210 1220 1230 1240 1250
MMGNGVLLSE DDTIYEGEFS DDWTLSGKGT LTMPHGDYIE GYFSGEWGSG
1260 1270 1280 1290 1300
IKITGTYFKP SLYESDKDKP KAFRKLGNLA VAADEKWRAV FEECWRQLGC
1310 1320 1330 1340 1350
ESPGQGEVWK AWDNIAVALT TNRRQHKDSP EILSRSQTQT LESLEYIPQH
1360 1370 1380 1390 1400
IGAFSVEKYD DIKKYLIKAC DTPLHPLGRL VETLVAVYRM TYVGVGANRR
1410 1420 1430 1440 1450
LLQEAVKEIK SYLKRIFQLV RFLFPELPEE GSTIPLSAPL PTGRRSFCTG
1460 1470 1480 1490 1500
KSDSRSESPE PGYVVTSSGL LLPVLLPRLY PPLFMLYALD NDREEDIYWE
1510 1520 1530 1540 1550
CVLRLNKQPD IALLGFLGVQ KKFWPATLSI LGESKKVLST TKDACFASAV
1560 1570 1580 1590 1600
ECLQQISTTF TPSDKLKVIQ QTFEEISQSV LASLQEDFLW SMDDLFPVFL
1610 1620 1630 1640 1650
YVVLRARIRN LGSEVHLIED LMDPFLQHGE QGIMFTTLKA CYFQIQREKL

N
Length:1,651
Mass (Da):182,566
Last modified:October 3, 2012 - v3
Checksum:iF9A9DBCA1ED423B2
GO
Isoform 2Curated (identifier: Q920R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     855-928: TSPEYQKLQD...LQHAGRFSVN → VGFVCAPPNT...MRSDALFWSV
     929-1651: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:928
Mass (Da):100,103
Checksum:iF4EF20522FF88C32
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSC7A0A087WSC7_MOUSE
Alsin
Als2
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318V → I in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti318V → I in AAH31479 (PubMed:15489334).Curated1
Sequence conflicti469L → S in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti469L → S in AAH31479 (PubMed:15489334).Curated1
Sequence conflicti764V → F in AAH46828 (PubMed:15489334).Curated1
Sequence conflicti1206V → L in BAB29271 (PubMed:16141072).Curated1
Sequence conflicti1296R → H in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti1452S → L in BAB69016 (PubMed:11586298).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050525855 – 928TSPEY…RFSVN → VGFVCAPPNTREAKSQSSLF ALSLLKMLGPGAGEMAQWVR APDCSSEGLEFKSQQPHGGS QPPVMRSDALFWSV in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_050526929 – 1651Missing in isoform 2. 1 PublicationAdd BLAST723

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053307 mRNA Translation: BAB69016.1
AC153652 Genomic DNA No translation available.
CH466548 Genomic DNA Translation: EDL00124.1
BC031479 mRNA Translation: AAH31479.1
BC046828 mRNA Translation: AAH46828.1
AK014320 mRNA Translation: BAB29271.2
CCDSiCCDS35583.1 [Q920R0-1]
RefSeqiNP_001153420.2, NM_001159948.2 [Q920R0-1]
NP_082993.4, NM_028717.6 [Q920R0-1]
NP_666221.1, NM_146109.3
UniGeneiMm.272078
Mm.474049

Genome annotation databases

EnsembliENSMUST00000027178; ENSMUSP00000027178; ENSMUSG00000026024 [Q920R0-1]
ENSMUST00000163058; ENSMUSP00000125753; ENSMUSG00000026024 [Q920R0-1]
GeneIDi74018
KEGGimmu:74018
UCSCiuc007bdm.2 mouse [Q920R0-1]
uc007bdn.2 mouse [Q920R0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053307 mRNA Translation: BAB69016.1
AC153652 Genomic DNA No translation available.
CH466548 Genomic DNA Translation: EDL00124.1
BC031479 mRNA Translation: AAH31479.1
BC046828 mRNA Translation: AAH46828.1
AK014320 mRNA Translation: BAB29271.2
CCDSiCCDS35583.1 [Q920R0-1]
RefSeqiNP_001153420.2, NM_001159948.2 [Q920R0-1]
NP_082993.4, NM_028717.6 [Q920R0-1]
NP_666221.1, NM_146109.3
UniGeneiMm.272078
Mm.474049

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216427, 4 interactors
STRINGi10090.ENSMUSP00000027178

PTM databases

iPTMnetiQ920R0
PhosphoSitePlusiQ920R0

Proteomic databases

EPDiQ920R0
PaxDbiQ920R0
PeptideAtlasiQ920R0
PRIDEiQ920R0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027178; ENSMUSP00000027178; ENSMUSG00000026024 [Q920R0-1]
ENSMUST00000163058; ENSMUSP00000125753; ENSMUSG00000026024 [Q920R0-1]
GeneIDi74018
KEGGimmu:74018
UCSCiuc007bdm.2 mouse [Q920R0-1]
uc007bdn.2 mouse [Q920R0-2]

Organism-specific databases

CTDi57679
MGIiMGI:1921268 Als2

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00730000110297
HOGENOMiHOG000033908
HOVERGENiHBG037320
InParanoidiQ920R0
KOiK04575
OMAiATCFEVT
OrthoDBiEOG091G00CU
TreeFamiTF331793

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiAls2 mouse
PROiPR:Q920R0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026024 Expressed in 107 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ920R0 baseline and differential
GenevisibleiQ920R0 MM

Family and domain databases

Gene3Di1.20.1050.80, 1 hit
1.20.900.10, 1 hit
2.130.10.30, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF00415 RCC1, 4 hits
PF00621 RhoGEF, 1 hit
PF02204 VPS9, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00698 MORN, 8 hits
SUPFAMiSSF109993 SSF109993, 1 hit
SSF48065 SSF48065, 1 hit
SSF50985 SSF50985, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 4 hits
PS51205 VPS9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALS2_MOUSE
AccessioniPrimary (citable) accession number: Q920R0
Secondary accession number(s): G5E868, Q8JZR1, Q9CXJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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