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Entry version 156 (16 Oct 2019)
Sequence version 3 (03 Oct 2012)
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Protein

Alsin

Gene

Als2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alsin
Alternative name(s):
Amyotrophic lateral sclerosis 2 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Als2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921268 Als2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809041 – 1651AlsinAdd BLAST1651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei459PhosphoserineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei504PhosphothreonineBy similarity1
Modified residuei527N6-acetyllysineCombined sources1
Modified residuei1329PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q920R0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q920R0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q920R0

PeptideAtlas

More...
PeptideAtlasi
Q920R0

PRoteomics IDEntifications database

More...
PRIDEi
Q920R0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q920R0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q920R0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q920R0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026024 Expressed in 107 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q920R0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q920R0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heteromeric complex with ALS2CL.

Interacts with ALS2CL (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
216427, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027178

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati59 – 108RCC1 1CuratedAdd BLAST50
Repeati109 – 167RCC1 2CuratedAdd BLAST59
Repeati169 – 218RCC1 3CuratedAdd BLAST50
Repeati519 – 570RCC1 4CuratedAdd BLAST52
Repeati572 – 621RCC1 5CuratedAdd BLAST50
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini684 – 879DHPROSITE-ProRule annotationAdd BLAST196
Domaini895 – 1001PHCuratedAdd BLAST107
Repeati1043 – 1065MORN 1Add BLAST23
Repeati1066 – 1088MORN 2Add BLAST23
Repeati1094 – 1116MORN 3Add BLAST23
Repeati1117 – 1139MORN 4Add BLAST23
Repeati1145 – 1167MORN 5Add BLAST23
Repeati1169 – 1191MORN 6Add BLAST23
Repeati1192 – 1214MORN 7Add BLAST23
Repeati1215 – 1238MORN 8Add BLAST24
Domaini1507 – 1651VPS9PROSITE-ProRule annotationAdd BLAST145

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q920R0

KEGG Orthology (KO)

More...
KOi
K04575

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQHIGAF

Database of Orthologous Groups

More...
OrthoDBi
37470at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331793

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1050.80, 1 hit
1.20.900.10, 1 hit
2.130.10.30, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003123 VPS9
IPR037191 VPS9_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02493 MORN, 7 hits
PF00415 RCC1, 4 hits
PF00621 RhoGEF, 1 hit
PF02204 VPS9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00698 MORN, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109993 SSF109993, 1 hit
SSF48065 SSF48065, 1 hit
SSF50985 SSF50985, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 4 hits
PS51205 VPS9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q920R0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSKKKSSTE AEGSKERGLV HVWQAGSFSL TPERLPGWGG KTVLQAALGV
60 70 80 90 100
RHGVLLTEDG EVYSFGTLPW KSESAEICPS SPLLESALVG HHVITVATGS
110 120 130 140 150
FHSGAVTESG VVYMWGENAA GQCAVANQQY VPEPSPVSIS DSETSPSLAV
160 170 180 190 200
RILQLACGEE HTLALSLSRE IWAWGTGCQL GLITTTFPVT KPQKVEHLAG
210 220 230 240 250
RVVLQVACGA FHSLALVQCL PPQDLKPVPE RCNQCSQLLI TMTDKEDHVI
260 270 280 290 300
ISDSHCCPLG VTLSESQAEK HASPAPSPHP EALDEQGEVF ENTVVEAELN
310 320 330 340 350
MGSSQTTSGS AISTQQNVVG TAEVSSARTA PSYPDTHAVT AYLQKLSEHS
360 370 380 390 400
MRENHEPGEK PPQVQPLVEE AVPDLHSPPT TSTSALNSLV VSCASAVGVR
410 420 430 440 450
VAATYEAGAL SLKKVMNFYS TAPCETAAQS GSASTGPESL KDLREEQVKQ
460 470 480 490 500
ESLQGKKSSS LMDIREEELE GGSRRLSLPG LLSQVSPRLL RKAARVKTRT
510 520 530 540 550
VVLTPTYSGE ADALLPSLRT EVWTWGKGKE GQLGHGDVLP RLQPLCVKCL
560 570 580 590 600
DGKEVIHLEA GGSHSLALTA KSQVYSWGSN TFGQLGHSEF PTTVPRLSKV
610 620 630 640 650
SSENGVWSVA AGQDYSLFLV DTEDFQPGLY YSGRQDRAEG DTLPENPSGT
660 670 680 690 700
KTPVLLSCSK LGYISRVTAG KDSYLALVDK NIMGYIASLH ELASTERRFY
710 720 730 740 750
SKLSEIKSQI LRPLLSLENL GTVTTVQLLQ EVASRFSKLC YLIGQHGASL
760 770 780 790 800
SSYLQGMKEA SSLVIMKHSS LFLDSYTEYC TSVSNFLVMG GFQLLAKPAI
810 820 830 840 850
DFLNKNQELL QDLSEVNDEN TQLMEILNML FFLPIRRLHN YAKVLLKLAT
860 870 880 890 900
CFEVTSPEYQ KLQDSSSCYE SLALHLGKKR KEAEYTLSFW KTFPGKMTDS
910 920 930 940 950
LRKPERRLLC ESSNRALSLQ HAGRFSVNWF ILFNDALVHA QFSTHHVFPL
960 970 980 990 1000
ATLWAEPLSE EAGSVNGLKI TTPEEQFTLI SSTPQEKTKW LRAISQAVDQ
1010 1020 1030 1040 1050
ALRGTSDFPL YGGGSSVQRQ EPPISRSAKY TFYKDTRLKD ATYDGRWLSG
1060 1070 1080 1090 1100
KPHGRGVLKW PDGKMYSGMF RNGLEDGYGE YRIPNKALNK EDHYVGHWKE
1110 1120 1130 1140 1150
GKMCGQGVYS YASGEVFEGC FQDNMRHGHG LLRSGKLTSS SPSMFIGQWV
1160 1170 1180 1190 1200
MDKKAGYGVF DDITRGEKYM GMWQDDVCQG NGVVVTQFGL YYEGNFHLNK
1210 1220 1230 1240 1250
MMGNGVLLSE DDTIYEGEFS DDWTLSGKGT LTMPHGDYIE GYFSGEWGSG
1260 1270 1280 1290 1300
IKITGTYFKP SLYESDKDKP KAFRKLGNLA VAADEKWRAV FEECWRQLGC
1310 1320 1330 1340 1350
ESPGQGEVWK AWDNIAVALT TNRRQHKDSP EILSRSQTQT LESLEYIPQH
1360 1370 1380 1390 1400
IGAFSVEKYD DIKKYLIKAC DTPLHPLGRL VETLVAVYRM TYVGVGANRR
1410 1420 1430 1440 1450
LLQEAVKEIK SYLKRIFQLV RFLFPELPEE GSTIPLSAPL PTGRRSFCTG
1460 1470 1480 1490 1500
KSDSRSESPE PGYVVTSSGL LLPVLLPRLY PPLFMLYALD NDREEDIYWE
1510 1520 1530 1540 1550
CVLRLNKQPD IALLGFLGVQ KKFWPATLSI LGESKKVLST TKDACFASAV
1560 1570 1580 1590 1600
ECLQQISTTF TPSDKLKVIQ QTFEEISQSV LASLQEDFLW SMDDLFPVFL
1610 1620 1630 1640 1650
YVVLRARIRN LGSEVHLIED LMDPFLQHGE QGIMFTTLKA CYFQIQREKL

N
Length:1,651
Mass (Da):182,566
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9A9DBCA1ED423B2
GO
Isoform 2Curated (identifier: Q920R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     855-928: TSPEYQKLQD...LQHAGRFSVN → VGFVCAPPNT...MRSDALFWSV
     929-1651: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:928
Mass (Da):100,103
Checksum:iF4EF20522FF88C32
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSC7A0A087WSC7_MOUSE
Alsin
Als2
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti318V → I in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti318V → I in AAH31479 (PubMed:15489334).Curated1
Sequence conflicti469L → S in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti469L → S in AAH31479 (PubMed:15489334).Curated1
Sequence conflicti764V → F in AAH46828 (PubMed:15489334).Curated1
Sequence conflicti1206V → L in BAB29271 (PubMed:16141072).Curated1
Sequence conflicti1296R → H in BAB69016 (PubMed:11586298).Curated1
Sequence conflicti1452S → L in BAB69016 (PubMed:11586298).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050525855 – 928TSPEY…RFSVN → VGFVCAPPNTREAKSQSSLF ALSLLKMLGPGAGEMAQWVR APDCSSEGLEFKSQQPHGGS QPPVMRSDALFWSV in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_050526929 – 1651Missing in isoform 2. 1 PublicationAdd BLAST723

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB053307 mRNA Translation: BAB69016.1
AC153652 Genomic DNA No translation available.
CH466548 Genomic DNA Translation: EDL00124.1
BC031479 mRNA Translation: AAH31479.1
BC046828 mRNA Translation: AAH46828.1
AK014320 mRNA Translation: BAB29271.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35583.1 [Q920R0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001153420.2, NM_001159948.2 [Q920R0-1]
NP_082993.4, NM_028717.6 [Q920R0-1]
NP_666221.1, NM_146109.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027178; ENSMUSP00000027178; ENSMUSG00000026024 [Q920R0-1]
ENSMUST00000163058; ENSMUSP00000125753; ENSMUSG00000026024 [Q920R0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
74018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74018

UCSC genome browser

More...
UCSCi
uc007bdm.2 mouse [Q920R0-1]
uc007bdn.2 mouse [Q920R0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053307 mRNA Translation: BAB69016.1
AC153652 Genomic DNA No translation available.
CH466548 Genomic DNA Translation: EDL00124.1
BC031479 mRNA Translation: AAH31479.1
BC046828 mRNA Translation: AAH46828.1
AK014320 mRNA Translation: BAB29271.2
CCDSiCCDS35583.1 [Q920R0-1]
RefSeqiNP_001153420.2, NM_001159948.2 [Q920R0-1]
NP_082993.4, NM_028717.6 [Q920R0-1]
NP_666221.1, NM_146109.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi216427, 4 interactors
STRINGi10090.ENSMUSP00000027178

PTM databases

iPTMnetiQ920R0
PhosphoSitePlusiQ920R0
SwissPalmiQ920R0

Proteomic databases

EPDiQ920R0
jPOSTiQ920R0
PaxDbiQ920R0
PeptideAtlasiQ920R0
PRIDEiQ920R0

Genome annotation databases

EnsembliENSMUST00000027178; ENSMUSP00000027178; ENSMUSG00000026024 [Q920R0-1]
ENSMUST00000163058; ENSMUSP00000125753; ENSMUSG00000026024 [Q920R0-1]
GeneIDi74018
KEGGimmu:74018
UCSCiuc007bdm.2 mouse [Q920R0-1]
uc007bdn.2 mouse [Q920R0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57679
MGIiMGI:1921268 Als2

Phylogenomic databases

eggNOGiKOG0231 Eukaryota
KOG1426 Eukaryota
COG4642 LUCA
GeneTreeiENSGT00940000155861
HOGENOMiHOG000033908
InParanoidiQ920R0
KOiK04575
OMAiPQHIGAF
OrthoDBi37470at2759
TreeFamiTF331793

Enzyme and pathway databases

ReactomeiR-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Als2 mouse

Protein Ontology

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PROi
PR:Q920R0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026024 Expressed in 107 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ920R0 baseline and differential
GenevisibleiQ920R0 MM

Family and domain databases

Gene3Di1.20.1050.80, 1 hit
1.20.900.10, 1 hit
2.130.10.30, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003409 MORN
IPR011993 PH-like_dom_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003123 VPS9
IPR037191 VPS9_dom_sf
PfamiView protein in Pfam
PF02493 MORN, 7 hits
PF00415 RCC1, 4 hits
PF00621 RhoGEF, 1 hit
PF02204 VPS9, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00698 MORN, 8 hits
SUPFAMiSSF109993 SSF109993, 1 hit
SSF48065 SSF48065, 1 hit
SSF50985 SSF50985, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 4 hits
PS51205 VPS9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q920R0
Secondary accession number(s): G5E868, Q8JZR1, Q9CXJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 3, 2012
Last modified: October 16, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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