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Protein

Influenza virus NS1A-binding protein homolog

Gene

Ivns1abp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity).By similarity3 Publications
Isoform 2: May play a role in cell cycle progression in the nucleus.1 Publication

Miscellaneous

Transgenic mice overexpressing Ivns1abp develop normally with no gross abnormalities up to 7-month old. However, they display a marked resistance to the cardiotoxic effect of doxorubicin which is an anti-neoplastic agent known to affect actin skeleton and an effective drug for cancer therapy with cardiotoxicity as side effect. Overexpression of Ivns1abp in the heart protect cardiomyocytes from apoptosis and improved survival rate after doxorubicin injection.1 Publication
Disorganized actin skeleton is observed in cells transfected with isoform 2 (Nd1-S), which lacks the six kelch repeats.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Influenza virus NS1A-binding protein homolog
Short name:
NS1-BP
Short name:
NS1-binding protein homolog
Alternative name(s):
Kelch family protein Nd1-L
ND1-L2
Nd1-S
Gene namesi
Name:Ivns1abp
Synonyms:Kiaa0850, Nd1, Nd1L, Nd1S, Ns1, Ns1bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2152389 Ivns1abp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally with no gross abnormalities. However, they display marked sensitivity to doxorubicin cardiotoxicity with increased number of cardiomyocytes apoptosis. Analysis of hearts from knockout mice reveal vacuolization and edema of cardiomaycytes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850781 – 642Influenza virus NS1A-binding protein homologAdd BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246PhosphoserineCombined sources1
Modified residuei277PhosphoserineBy similarity1
Modified residuei322PhosphoserineCombined sources1
Modified residuei336PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ920Q8
PeptideAtlasiQ920Q8
PRIDEiQ920Q8

PTM databases

iPTMnetiQ920Q8
PhosphoSitePlusiQ920Q8

Expressioni

Tissue specificityi

Ubiquitous expression. In the heart, the highest expression is detected in the ventricles and the lowest in the atria. Expressed in dendrites and spines in neurons.3 Publications

Developmental stagei

Barely detected in the heart at E15.5, but clearly expressed in newborn heart with increased amount up to 8 weeks of age.1 Publication

Inductioni

Decreased expression in various organs and cultured cell lines by doxorubicin treatment which may reduce mRNA stability.2 Publications

Gene expression databases

BgeeiENSMUSG00000023150 Expressed in 326 organ(s), highest expression level in female gonad
CleanExiMM_IVNS1ABP
ExpressionAtlasiQ920Q8 baseline and differential
GenevisibleiQ920Q8 MM

Interactioni

Subunit structurei

Homodimer; through the BTB domain. Interacts with AHR/Aryl hydrocarbon receptor (By similarity).By similarity

Protein-protein interaction databases

BioGridi228184, 7 interactors
IntActiQ920Q8, 2 interactors
STRINGi10090.ENSMUSP00000023918

Structurei

3D structure databases

ProteinModelPortaliQ920Q8
SMRiQ920Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 99BTBPROSITE-ProRule annotationAdd BLAST68
Domaini134 – 233BACKAdd BLAST100
Repeati369 – 415Kelch 1Add BLAST47
Repeati416 – 463Kelch 2Add BLAST48
Repeati465 – 512Kelch 3Add BLAST48
Repeati513 – 559Kelch 4Add BLAST47
Repeati561 – 606Kelch 5Add BLAST46
Repeati608 – 642Kelch 6Add BLAST35

Domaini

When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP.By similarity

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOVERGENiHBG082407
InParanoidiQ920Q8
KOiK15046
OMAiPESNEWS
OrthoDBiEOG091G024F
PhylomeDBiQ920Q8
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029849 NS1BP
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24411:SF7 PTHR24411:SF7, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q920Q8-1) [UniParc]FASTAAdd to basket
Also known as: Nd1-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL
60 70 80 90 100
ACCSPYLFEI FNSDSDPHGV SHVKLDDLNP EAVEVLLNYA YTAQLKADKE
110 120 130 140 150
LVKDVYSAAK KLKMDRVKQV CGDYLLSRMD VTSCISYRNF ASCMGDSRLL
160 170 180 190 200
NKVDAYIQEH LLQISEEEEF LKLPRLKLEV MLEDNVCLPS NGKLYTKVIN
210 220 230 240 250
WVQRSIWENG DSLEELMEEV QTLYYSADHK LLDGNPLDGQ AEVFGSDDDH
260 270 280 290 300
IQFVQKKPPR ENGHKQISGS STGCLSSPNA SMQSPKHEWK IVASEKTSNN
310 320 330 340 350
TYLCLAVLDS TFCVIFLHGR NSPQSSPTST PKLSKSLSFE MQPDELLEKP
360 370 380 390 400
MSPMQYARSG LGTAEMNGKL IAAGGYNREE CLRTVECYDP HTDHWSFLAP
410 420 430 440 450
MRTPRARFQM AVLMGQLYVV GGSNGHSDDL SCGEMYDPNI DDWTPVPELR
460 470 480 490 500
TNRCNAGVCA LNGKLYIVGG SDPYGQKGLK NCDVFDPVTK SWTSCAPLNI
510 520 530 540 550
RRHQSAVCEL GGYLYIIGGA ESWNCLNTVE RYNPENNTWT LIAPMNVARR
560 570 580 590 600
GAGVAVLDGK LFVGGGFDGS HAISCVEMYD PTRNEWKMMG NMTSPRSNAG
610 620 630 640
ITTVGNTIYA VGGFDGNEFL NTVEVYNPQS NEWSPYTKIF QF
Length:642
Mass (Da):71,581
Last modified:May 1, 2007 - v2
Checksum:i7240360079C16B50
GO
Isoform 2 (identifier: Q920Q8-2) [UniParc]FASTAAdd to basket
Also known as: Nd1-S

The sequence of this isoform differs from the canonical sequence as follows:
     221-221: Q → Y
     222-642: Missing.

Show »
Length:221
Mass (Da):25,333
Checksum:i9A8EC762FEB9A7E5
GO
Isoform 3 (identifier: Q920Q8-3) [UniParc]FASTAAdd to basket
Also known as: Nd1-L2

The sequence of this isoform differs from the canonical sequence as follows:
     179-218: Missing.

Show »
Length:602
Mass (Da):66,916
Checksum:i1E9680A37A479696
GO
Isoform 4 (identifier: Q920Q8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-219: Missing.

Note: No experimental confirmation available.
Show »
Length:600
Mass (Da):66,673
Checksum:iAFE7313C1D09DE2D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQT3A0A087WQT3_MOUSE
Influenza virus NS1A-binding protei...
Ivns1abp
77Annotation score:

Sequence cautioni

The sequence BAC98039 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106Y → H in BAE26822 (PubMed:16141072).Curated1
Sequence conflicti201W → R in BAE34935 (PubMed:16141072).Curated1
Sequence conflicti285P → T in BAE27084 (PubMed:16141072).Curated1
Sequence conflicti295E → K in BAE27084 (PubMed:16141072).Curated1
Sequence conflicti544P → S in AAH04092 (PubMed:15489334).Curated1
Sequence conflicti548A → S in BAE27084 (PubMed:16141072).Curated1
Sequence conflicti549R → K in BAB69058 (PubMed:12213805).Curated1
Sequence conflicti589M → I in BAE27084 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024810178 – 219Missing in isoform 4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_024811179 – 218Missing in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_024812221Q → Y in isoform 2. 3 Publications1
Alternative sequenceiVSP_024813222 – 642Missing in isoform 2. 3 PublicationsAdd BLAST421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055737 mRNA Translation: BAB69058.1
AB055738 mRNA Translation: BAB69059.1
DQ914522 mRNA Translation: ABI84241.1
AK129229 mRNA Translation: BAC98039.1 Different initiation.
AK007291 mRNA Translation: BAB24936.1
AK144835 mRNA Translation: BAE26089.1
AK145071 mRNA Translation: BAE26221.1
AK146001 mRNA Translation: BAE26822.1
AK146329 mRNA Translation: BAE27084.1
AK146494 mRNA Translation: BAE27212.1
AK146645 mRNA Translation: BAE27326.1
AK159254 mRNA Translation: BAE34935.1
BC004092 mRNA Translation: AAH04092.1
BC040250 mRNA Translation: AAH40250.1
CCDSiCCDS15358.1 [Q920Q8-4]
CCDS15359.1 [Q920Q8-1]
CCDS35735.1 [Q920Q8-2]
RefSeqiNP_001034600.1, NM_001039511.1 [Q920Q8-2]
NP_001034601.1, NM_001039512.1 [Q920Q8-4]
NP_473443.2, NM_054102.2 [Q920Q8-1]
UniGeneiMm.33764

Genome annotation databases

EnsembliENSMUST00000023918; ENSMUSP00000023918; ENSMUSG00000023150 [Q920Q8-1]
ENSMUST00000097543; ENSMUSP00000095150; ENSMUSG00000023150 [Q920Q8-4]
ENSMUST00000111887; ENSMUSP00000107518; ENSMUSG00000023150 [Q920Q8-2]
ENSMUST00000186745; ENSMUSP00000140708; ENSMUSG00000023150 [Q920Q8-2]
GeneIDi117198
KEGGimmu:117198
UCSCiuc007cym.1 mouse [Q920Q8-2]
uc007cyn.1 mouse [Q920Q8-1]
uc007cyo.1 mouse [Q920Q8-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055737 mRNA Translation: BAB69058.1
AB055738 mRNA Translation: BAB69059.1
DQ914522 mRNA Translation: ABI84241.1
AK129229 mRNA Translation: BAC98039.1 Different initiation.
AK007291 mRNA Translation: BAB24936.1
AK144835 mRNA Translation: BAE26089.1
AK145071 mRNA Translation: BAE26221.1
AK146001 mRNA Translation: BAE26822.1
AK146329 mRNA Translation: BAE27084.1
AK146494 mRNA Translation: BAE27212.1
AK146645 mRNA Translation: BAE27326.1
AK159254 mRNA Translation: BAE34935.1
BC004092 mRNA Translation: AAH04092.1
BC040250 mRNA Translation: AAH40250.1
CCDSiCCDS15358.1 [Q920Q8-4]
CCDS15359.1 [Q920Q8-1]
CCDS35735.1 [Q920Q8-2]
RefSeqiNP_001034600.1, NM_001039511.1 [Q920Q8-2]
NP_001034601.1, NM_001039512.1 [Q920Q8-4]
NP_473443.2, NM_054102.2 [Q920Q8-1]
UniGeneiMm.33764

3D structure databases

ProteinModelPortaliQ920Q8
SMRiQ920Q8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228184, 7 interactors
IntActiQ920Q8, 2 interactors
STRINGi10090.ENSMUSP00000023918

PTM databases

iPTMnetiQ920Q8
PhosphoSitePlusiQ920Q8

Proteomic databases

PaxDbiQ920Q8
PeptideAtlasiQ920Q8
PRIDEiQ920Q8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023918; ENSMUSP00000023918; ENSMUSG00000023150 [Q920Q8-1]
ENSMUST00000097543; ENSMUSP00000095150; ENSMUSG00000023150 [Q920Q8-4]
ENSMUST00000111887; ENSMUSP00000107518; ENSMUSG00000023150 [Q920Q8-2]
ENSMUST00000186745; ENSMUSP00000140708; ENSMUSG00000023150 [Q920Q8-2]
GeneIDi117198
KEGGimmu:117198
UCSCiuc007cym.1 mouse [Q920Q8-2]
uc007cyn.1 mouse [Q920Q8-1]
uc007cyo.1 mouse [Q920Q8-4]

Organism-specific databases

CTDi10625
MGIiMGI:2152389 Ivns1abp
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOVERGENiHBG082407
InParanoidiQ920Q8
KOiK15046
OMAiPESNEWS
OrthoDBiEOG091G024F
PhylomeDBiQ920Q8
TreeFamiTF329218

Miscellaneous databases

ChiTaRSiIvns1abp mouse
PROiPR:Q920Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023150 Expressed in 326 organ(s), highest expression level in female gonad
CleanExiMM_IVNS1ABP
ExpressionAtlasiQ920Q8 baseline and differential
GenevisibleiQ920Q8 MM

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR029849 NS1BP
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24411:SF7 PTHR24411:SF7, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNS1BP_MOUSE
AccessioniPrimary (citable) accession number: Q920Q8
Secondary accession number(s): Q06BK6
, Q3TXI1, Q3UJE3, Q3UJS1, Q3UKH9, Q3UMK9, Q6ZQ34, Q99KN0, Q9D978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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