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Protein

RNA-binding protein Musashi homolog 2

Gene

Msi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.2 Publications

GO - Molecular functioni

  • poly(U) RNA binding Source: MGI
  • single-stranded RNA binding Source: MGI

GO - Biological processi

  • stem cell development Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog 2
Short name:
Musashi-2
Gene namesi
Name:Msi2
Synonyms:Msi2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1923876 Msi2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816531 – 346RNA-binding protein Musashi homolog 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei228Omega-N-methylarginineCombined sources1
Modified residuei261Omega-N-methylarginineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ920Q6
PRIDEiQ920Q6

PTM databases

iPTMnetiQ920Q6
PhosphoSitePlusiQ920Q6

Expressioni

Tissue specificityi

Ubiquitous. Expressed in proliferating neural precursor cells.2 Publications

Inductioni

Up-regulated in astrocytes after brain injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000069769 Expressed in 259 organ(s), highest expression level in pineal body
CleanExiMM_MSI2
ExpressionAtlasiQ920Q6 baseline and differential
GenevisibleiQ920Q6 MM

Interactioni

Protein-protein interaction databases

BioGridi218215, 1 interactor
IntActiQ920Q6, 6 interactors
MINTiQ920Q6
STRINGi10090.ENSMUSP00000090470

Structurei

3D structure databases

ProteinModelPortaliQ920Q6
SMRiQ920Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 111RRM 1PROSITE-ProRule annotationAdd BLAST91
Domaini110 – 187RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 260Poly-Ala8

Sequence similaritiesi

Belongs to the Musashi family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ920Q6
KOiK14411
OMAiSGFSHGI
OrthoDBiEOG091G1CPI
PhylomeDBiQ920Q6

Family and domain databases

CDDicd12576 RRM1_MSI, 1 hit
cd12323 RRM2_MSI, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034130 MSI_RRM1
IPR034126 MSI_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q920Q6-1) [UniParc]FASTAAdd to basket
Also known as: Msi2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEANGSPGTS GSANDSQHDP GKMFIGGLSW QTSPDSLRDY FSKFGEIREC
60 70 80 90 100
MVMRDPTTKR SRGFGFVTFA DPASVDKVLG QPHHELDSKT IDPKVAFPRR
110 120 130 140 150
AQPKMVTRTK KIFVGGLSAN TVVEDVKQYF EQFGKVEDAM LMFDKTTNRH
160 170 180 190 200
RGFGFVTFEN EDVVEKVCEI HFHEINNKMV ECKKAQPKEV MFPPGTRGRA
210 220 230 240 250
RGLPYTMDAF MLGMGMLGYP NFVATYGRGY PGFAPSYGYQ FPGFPAAAYG
260 270 280 290 300
PVAAAAVAAA RGSVLNSYSA QPNFGAPASP AGSNPARPGG FPGANSPGPV
310 320 330 340
ADLYGPASQD SGVGNYISAA SPQPGSGFGH GIAGPLIATA FTNGYH
Length:346
Mass (Da):36,939
Last modified:December 1, 2001 - v1
Checksum:iC2C75F2D7077AF61
GO
Isoform 2 (identifier: Q920Q6-2) [UniParc]FASTAAdd to basket
Also known as: Msi2S

The sequence of this isoform differs from the canonical sequence as follows:
     264-281: Missing.

Show »
Length:328
Mass (Da):35,166
Checksum:i6EB14C42397CA627
GO
Isoform 3 (identifier: Q920Q6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-282: VLNSYSAQPNFGAPASPAG → GRKVYGAGGSQACLVCRGR
     283-346: Missing.

Note: No experimental confirmation available.
Show »
Length:282
Mass (Da):30,893
Checksum:i156B6685DC0EE4B8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AT13B1AT13_MOUSE
RNA-binding protein Musashi homolog...
Msi2
158Annotation score:
B1AT10B1AT10_MOUSE
RNA-binding protein Musashi homolog...
Msi2
113Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011172264 – 282VLNSY…ASPAG → GRKVYGAGGSQACLVCRGR in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_011173264 – 281Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_011174283 – 346Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056102 mRNA Translation: BAB69484.1
AB056103 mRNA Translation: BAB69485.1
BK001483 mRNA Translation: DAA01567.1
AK049637 mRNA Translation: BAC33851.1
AK049688 mRNA Translation: BAC33873.1
AK051269 mRNA Translation: BAC34584.1
CCDSiCCDS56796.1 [Q920Q6-1]
RefSeqiNP_473384.1, NM_054043.3 [Q920Q6-1]
XP_006534505.1, XM_006534442.3
UniGeneiMm.400451
Mm.428433
Mm.474737

Genome annotation databases

EnsembliENSMUST00000092794; ENSMUSP00000090470; ENSMUSG00000069769 [Q920Q6-1]
ENSMUST00000107909; ENSMUSP00000103542; ENSMUSG00000069769 [Q920Q6-2]
GeneIDi76626
KEGGimmu:76626
UCSCiuc007kvl.2 mouse [Q920Q6-1]
uc007kvn.2 mouse [Q920Q6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056102 mRNA Translation: BAB69484.1
AB056103 mRNA Translation: BAB69485.1
BK001483 mRNA Translation: DAA01567.1
AK049637 mRNA Translation: BAC33851.1
AK049688 mRNA Translation: BAC33873.1
AK051269 mRNA Translation: BAC34584.1
CCDSiCCDS56796.1 [Q920Q6-1]
RefSeqiNP_473384.1, NM_054043.3 [Q920Q6-1]
XP_006534505.1, XM_006534442.3
UniGeneiMm.400451
Mm.428433
Mm.474737

3D structure databases

ProteinModelPortaliQ920Q6
SMRiQ920Q6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218215, 1 interactor
IntActiQ920Q6, 6 interactors
MINTiQ920Q6
STRINGi10090.ENSMUSP00000090470

PTM databases

iPTMnetiQ920Q6
PhosphoSitePlusiQ920Q6

Proteomic databases

PaxDbiQ920Q6
PRIDEiQ920Q6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092794; ENSMUSP00000090470; ENSMUSG00000069769 [Q920Q6-1]
ENSMUST00000107909; ENSMUSP00000103542; ENSMUSG00000069769 [Q920Q6-2]
GeneIDi76626
KEGGimmu:76626
UCSCiuc007kvl.2 mouse [Q920Q6-1]
uc007kvn.2 mouse [Q920Q6-3]

Organism-specific databases

CTDi124540
MGIiMGI:1923876 Msi2

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ920Q6
KOiK14411
OMAiSGFSHGI
OrthoDBiEOG091G1CPI
PhylomeDBiQ920Q6

Miscellaneous databases

ChiTaRSiMsi2 mouse
PROiPR:Q920Q6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069769 Expressed in 259 organ(s), highest expression level in pineal body
CleanExiMM_MSI2
ExpressionAtlasiQ920Q6 baseline and differential
GenevisibleiQ920Q6 MM

Family and domain databases

CDDicd12576 RRM1_MSI, 1 hit
cd12323 RRM2_MSI, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034130 MSI_RRM1
IPR034126 MSI_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMSI2H_MOUSE
AccessioniPrimary (citable) accession number: Q920Q6
Secondary accession number(s): Q8BQ90, Q920Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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