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Protein

Elongation of very long chain fatty acids protein 6

Gene

Elovl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation2 Publications

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs
UniPathwayi
UPA00094

Chemistry databases

SwissLipidsiSLP:000000454

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 6UniRule annotationCurated (EC:2.3.1.199UniRule annotation1 Publication)
Alternative name(s):
3-keto acyl-CoA synthase Elovl6UniRule annotation
ELOVL fatty acid elongase 6UniRule annotation
Short name:
ELOVL FA elongase 6UniRule annotation
Fatty acyl-CoA elongase
Long chain fatty acid elongase
Myelin-associated SUR4 protein
Very long chain 3-ketoacyl-CoA synthase 6UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 6UniRule annotation
Gene namesi
Name:Elovl6UniRule annotation
Synonyms:Face, Lce, Masr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2156528 Elovl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 51HelicalUniRule annotationAdd BLAST18
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Transmembranei136 – 156HelicalUniRule annotationAdd BLAST21
Transmembranei159 – 179HelicalUniRule annotationAdd BLAST21
Transmembranei197 – 217HelicalUniRule annotationAdd BLAST21
Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828461 – 267Elongation of very long chain fatty acids protein 6Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineUniRule annotation1

Post-translational modificationi

N-Glycosylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ920L5
PaxDbiQ920L5
PeptideAtlasiQ920L5
PRIDEiQ920L5

PTM databases

PhosphoSitePlusiQ920L5

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, liver, white adipose tissue (WAT), adult and fetal brain, cerebellum, spinal cord, testis, skin and peripheral nerve; where lipogenesis and steroidogenesis are active. Weakly expressed in kidney, heart, skeletal muscle, lung, and spleen.3 Publications

Inductioni

By SREBF1.2 Publications

Gene expression databases

BgeeiENSMUSG00000041220 Expressed in 309 organ(s), highest expression level in cochlea
ExpressionAtlasiQ920L5 baseline and differential
GenevisibleiQ920L5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071351

Chemistry databases

BindingDBiQ920L5

Structurei

3D structure databases

ProteinModelPortaliQ920L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family. ELOVL6 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3072 Eukaryota
ENOG410Z3FZ LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038943
HOVERGENiHBG099423
InParanoidiQ920L5
KOiK10203
OMAiEYEFERQ
OrthoDBiEOG091G0EKU
PhylomeDBiQ920L5
TreeFamiTF106467

Family and domain databases

HAMAPiMF_03206 VLCF_elongase_6, 1 hit
InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
IPR033675 ELOVL6
PANTHERiPTHR11157 PTHR11157, 1 hit
PTHR11157:SF42 PTHR11157:SF42, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q920L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMSVLTLQE YEFEKQFNEN EAIQWMQENW KKSFLFSALY AAFIFGGRHL
60 70 80 90 100
MNKRAKFELR KPLVLWSLTL AVFSIFGALR TGAYMLYILM TKGLKQSVCD
110 120 130 140 150
QSFYNGPVSK FWAYAFVLSK APELGDTIFI ILRKQKLIFL HWYHHITVLL
160 170 180 190 200
YSWYSYKDMV AGGGWFMTMN YGVHAVMYSY YALRAAGFRV SRKFAMFITL
210 220 230 240 250
SQITQMLMGC VINYLVFNWM QHDNDQCYSH FQNIFWSSLM YLSYLVLFCH
260
FFFEAYIGKV KKATKAE
Length:267
Mass (Da):31,610
Last modified:December 1, 2001 - v1
Checksum:i4026C9CB33FDDD23
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFE8A0A0G2JFE8_MOUSE
Elongation of very long chain fatty...
Elovl6
200Annotation score:
A0A0G2JFD6A0A0G2JFD6_MOUSE
Elongation of very long chain fatty...
Elovl6
74Annotation score:
A0A0G2JGX5A0A0G2JGX5_MOUSE
Elongation of very long chain fatty...
Elovl6
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144H → Q in BAC26252 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY053453 mRNA Translation: AAL14239.1
AB072039 mRNA Translation: BAB68544.1
AF480860 mRNA Translation: AAM13450.1
AK029029 mRNA Translation: BAC26252.1
AK167373 mRNA Translation: BAE39469.1
BC051041 mRNA Translation: AAH51041.1
BC098492 mRNA Translation: AAH98492.1
BC100576 mRNA Translation: AAI00577.1
CCDSiCCDS38632.1
RefSeqiNP_569717.1, NM_130450.2
UniGeneiMm.314113

Genome annotation databases

EnsembliENSMUST00000071402; ENSMUSP00000071351; ENSMUSG00000041220
ENSMUST00000199910; ENSMUSP00000142832; ENSMUSG00000041220
GeneIDi170439
KEGGimmu:170439
UCSCiuc008rid.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY053453 mRNA Translation: AAL14239.1
AB072039 mRNA Translation: BAB68544.1
AF480860 mRNA Translation: AAM13450.1
AK029029 mRNA Translation: BAC26252.1
AK167373 mRNA Translation: BAE39469.1
BC051041 mRNA Translation: AAH51041.1
BC098492 mRNA Translation: AAH98492.1
BC100576 mRNA Translation: AAI00577.1
CCDSiCCDS38632.1
RefSeqiNP_569717.1, NM_130450.2
UniGeneiMm.314113

3D structure databases

ProteinModelPortaliQ920L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000071351

Chemistry databases

BindingDBiQ920L5
ChEMBLiCHEMBL5726
SwissLipidsiSLP:000000454

PTM databases

PhosphoSitePlusiQ920L5

Proteomic databases

MaxQBiQ920L5
PaxDbiQ920L5
PeptideAtlasiQ920L5
PRIDEiQ920L5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071402; ENSMUSP00000071351; ENSMUSG00000041220
ENSMUST00000199910; ENSMUSP00000142832; ENSMUSG00000041220
GeneIDi170439
KEGGimmu:170439
UCSCiuc008rid.1 mouse

Organism-specific databases

CTDi79071
MGIiMGI:2156528 Elovl6

Phylogenomic databases

eggNOGiKOG3072 Eukaryota
ENOG410Z3FZ LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038943
HOVERGENiHBG099423
InParanoidiQ920L5
KOiK10203
OMAiEYEFERQ
OrthoDBiEOG091G0EKU
PhylomeDBiQ920L5
TreeFamiTF106467

Enzyme and pathway databases

UniPathwayi
UPA00094

ReactomeiR-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

ChiTaRSiElovl6 mouse
PROiPR:Q920L5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041220 Expressed in 309 organ(s), highest expression level in cochlea
ExpressionAtlasiQ920L5 baseline and differential
GenevisibleiQ920L5 MM

Family and domain databases

HAMAPiMF_03206 VLCF_elongase_6, 1 hit
InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
IPR033675 ELOVL6
PANTHERiPTHR11157 PTHR11157, 1 hit
PTHR11157:SF42 PTHR11157:SF42, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELOV6_MOUSE
AccessioniPrimary (citable) accession number: Q920L5
Secondary accession number(s): Q8CE45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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