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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

Sdha

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Sdha)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei267FADBy similarity1
Binding sitei288SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1
Active sitei332Proton acceptorBy similarity1
Binding sitei399SubstrateBy similarity1
Binding sitei432FADBy similarity1
Binding sitei443SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 65FADBy similarity6
Nucleotide bindingi83 – 98FADBy similarityAdd BLAST16
Nucleotide bindingi448 – 449FADBy similarity2

GO - Molecular functioni

  • electron transfer activity Source: GO_Central
  • flavin adenine dinucleotide binding Source: InterPro
  • succinate dehydrogenase (ubiquinone) activity Source: RGD

GO - Biological processi

  • anaerobic respiration Source: GO_Central
  • mitochondrial electron transport, succinate to ubiquinone Source: GO_Central
  • nervous system development Source: Ensembl
  • respiratory electron transport chain Source: RGD
  • succinate metabolic process Source: RGD
  • tricarboxylic acid cycle Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.3.5.1 5301
ReactomeiR-RNO-71403 Citric acid cycle (TCA cycle)
SABIO-RKiQ920L2
UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
Fp
Gene namesi
Name:Sdha
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621557 Sdha

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000001033835 – 656Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Tele-8alpha-FAD histidineBy similarity1
Modified residuei171N6-acetyllysine; alternateBy similarity1
Modified residuei171N6-succinyllysine; alternateBy similarity1
Modified residuei174N6-acetyllysineBy similarity1
Modified residuei207Phosphotyrosine; by SRCBy similarity1
Modified residuei242N6-acetyllysine; alternateBy similarity1
Modified residuei242N6-succinyllysine; alternateBy similarity1
Modified residuei327N6-acetyllysine; alternateBy similarity1
Modified residuei327N6-succinyllysine; alternateBy similarity1
Modified residuei415N6-acetyllysineBy similarity1
Modified residuei472N6-acetyllysineBy similarity1
Modified residuei477N6-acetyllysine; alternateBy similarity1
Modified residuei477N6-succinyllysine; alternateBy similarity1
Modified residuei490N6-acetyllysine; alternateBy similarity1
Modified residuei490N6-succinyllysine; alternateBy similarity1
Modified residuei509N6-acetyllysineBy similarity1
Modified residuei530N6-acetyllysine; alternateBy similarity1
Modified residuei530N6-succinyllysine; alternateBy similarity1
Modified residuei542N6-acetyllysineBy similarity1
Modified residuei590N6-acetyllysineBy similarity1
Modified residuei600N6-acetyllysineBy similarity1
Modified residuei607N6-succinyllysineBy similarity1
Modified residuei616N6-acetyllysineBy similarity1
Modified residuei625N6-acetyllysineBy similarity1
Modified residuei628N6-acetyllysineBy similarity1
Modified residuei639N6-acetyllysineBy similarity1

Post-translational modificationi

Acetylated. Deacetylated by SIRT3.By similarity
Phosphorylation at Tyr-207 is important for efficient electron transfer in complex II and the prevention of ROS generation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ920L2
PRIDEiQ920L2

2D gel databases

World-2DPAGEi0004:Q920L2

PTM databases

CarbonylDBiQ920L2
iPTMnetiQ920L2
PhosphoSitePlusiQ920L2

Expressioni

Gene expression databases

BgeeiENSRNOG00000013331
GenevisibleiQ920L2 RN

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250905, 1 interactor
ComplexPortaliCPX-564 Mitochondrial respiratory chain complex II
CORUMiQ920L2
IntActiQ920L2, 1 interactor
STRINGi10116.ENSRNOP00000018336

Structurei

3D structure databases

ProteinModelPortaliQ920L2
SMRiQ920L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
GeneTreeiENSGT00910000144277
HOGENOMiHOG000160475
HOVERGENiHBG001461
InParanoidiQ920L2
KOiK00234
OMAiGDSPWEH
OrthoDBiEOG091G041Z
PhylomeDBiQ920L2

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q920L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVGAVSRL LRGRRLALAG ATRGFHFSVG ESKKASAKVS DAISTQYPVV
60 70 80 90 100
DHEFDAVVVG AGGAGLRAAF GLSEAGFNTA CLTKLFPTRS HTVAAQGGIN
110 120 130 140 150
AALGNMEEDN WRWHFYDTVK GSDWLGDQDA IHYMTEQAPA SVVELENYGM
160 170 180 190 200
PFSRTEDGRI YQRAFGGQSL KFGKGGQAHR CCCVADRTGH SLLHTLYGRS
210 220 230 240 250
LRYDTSYFVE YFALDLLMEN GECRGVIALC IEDGSIHRIR AKNTIIATGG
260 270 280 290 300
YGRTYFSCTS AHTSTGDGTA MVTRAGLPCQ DLEFVQFHPT GIYGAGCLIT
310 320 330 340 350
EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT LEIREGRGCG
360 370 380 390 400
PEKDHVYLQL HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY
410 420 430 440 450
NMGGIPTNYK GQVLKHVNGQ DQIVPGLYAC GEAACASVHG ANRLGANSLL
460 470 480 490 500
DLVVFGRACA LSIAESCRPG DKVPPIKANA GEESVMNLDK LRFADGSVRT
510 520 530 540 550
SELRLSMQKS MQSHAAVFRV GSVLQEGCEK VSQLYGDLQH LKTFDRGMVW
560 570 580 590 600
NTDLVETLEL QNLMLCALQT IYGAEARKES RGAHAREDYK VRIDEYDYSK
610 620 630 640 650
PIEGQQKKPF AEHWRKHTLS YVDTKTGKVT LDYRPVIDKT LNEADCATVP

PAIRSY
Length:656
Mass (Da):71,615
Last modified:December 1, 2001 - v1
Checksum:i9E820F7FF7EC3B36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072907 mRNA Translation: BAB69818.1
RefSeqiNP_569112.1, NM_130428.1
UniGeneiRn.228607

Genome annotation databases

EnsembliENSRNOT00000018336; ENSRNOP00000018336; ENSRNOG00000013331
GeneIDi157074
KEGGirno:157074
UCSCiRGD:621557 rat

Similar proteinsi

Entry informationi

Entry nameiSDHA_RAT
AccessioniPrimary (citable) accession number: Q920L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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