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Protein

Thioredoxin-like protein 1

Gene

Txnl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
Thioredoxin-related protein
Gene namesi
Name:Txnl1
Synonyms:Trp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi621717 Txnl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200181 – 289Thioredoxin-like protein 1Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-activeBy similarity
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ920J4
PRIDEiQ920J4

PTM databases

iPTMnetiQ920J4
PhosphoSitePlusiQ920J4

Expressioni

Gene expression databases

BgeeiENSRNOG00000018818
ExpressionAtlasiQ920J4 baseline and differential
GenevisibleiQ920J4 RN

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250856, 1 interactor
IntActiQ920J4, 2 interactors
MINTiQ920J4
STRINGi10116.ENSRNOP00000025510

Structurei

3D structure databases

ProteinModelPortaliQ920J4
SMRiQ920J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOGENOMiHOG000189802
HOVERGENiHBG055982
InParanoidiQ920J4

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q920J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDLSFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTLFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,249
Last modified:January 23, 2007 - v3
Checksum:i208973DC16B61E01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140358 mRNA Translation: AAK98516.1
BC098908 mRNA Translation: AAH98908.1
RefSeqiNP_543163.1, NM_080887.2
UniGeneiRn.40430

Genome annotation databases

EnsembliENSRNOT00000025510; ENSRNOP00000025510; ENSRNOG00000018818
GeneIDi140922
KEGGirno:140922
UCSCiRGD:621717 rat

Similar proteinsi

Entry informationi

Entry nameiTXNL1_RAT
AccessioniPrimary (citable) accession number: Q920J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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