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Protein

Germ cell-less protein-like 1

Gene

Gmcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport.

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Germ cell-less protein-like 1
Short name:
mGcl-1
Alternative name(s):
DP-interacting protein
Short name:
DIP
Gene namesi
Name:Gmcl1
Synonyms:Gcl, Gcl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1345156 Gmcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875211 – 524Germ cell-less protein-like 1Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1
Modified residuei66PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ920G9
MaxQBiQ920G9
PaxDbiQ920G9
PRIDEiQ920G9

PTM databases

iPTMnetiQ920G9
PhosphoSitePlusiQ920G9

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels throughout development and in adult tissues.

Developmental stagei

Highest levels in pachytene and diplotene stage spermatocytes and primordial germ cells of the male and the female.

Gene expression databases

BgeeiENSMUSG00000001157 Expressed in 272 organ(s), highest expression level in testis
CleanExiMM_GMCL1
ExpressionAtlasiQ920G9 baseline and differential
GenevisibleiQ920G9 MM

Interactioni

Subunit structurei

Interacts with TMPO-Beta, TSG101 and TFDP2. Interacts with EMD (By similarity).By similarity

Protein-protein interaction databases

BioGridi204775, 5 interactors
DIPiDIP-24259N
STRINGi10090.ENSMUSP00000001185

Structurei

3D structure databases

ProteinModelPortaliQ920G9
SMRiQ920G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 176BTBPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 53Nuclear localization signalSequence analysis7
Motifi83 – 89Nuclear localization signalSequence analysis7

Phylogenomic databases

eggNOGiKOG4682 Eukaryota
ENOG410XPEJ LUCA
GeneTreeiENSGT00390000003212
HOGENOMiHOG000232133
HOVERGENiHBG051741
InParanoidiQ920G9
KOiK10485
OMAiGAFCYCH
OrthoDBiEOG091G07ZV
PhylomeDBiQ920G9
TreeFamiTF316048

Family and domain databases

InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q920G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGALSSRVLR PAGRTEQPEP TPGAGGAARR SDAGEDAGHS FCYCPGGRKR
60 70 80 90 100
KRSSGTFCYC HPDSETDDDE DEGDEQQRLL NTPRRKKLKS TSKYIYQTLF
110 120 130 140 150
LNGENSDIKI CALGEEWSLH KIYLCQSGYF SSMFSGSWKE SSMNIIELEI
160 170 180 190 200
PDQNIDIEAL QVAFGSLYRD DVLIKPSRVV AILAAACMLQ LDGLIQQCGE
210 220 230 240 250
TMKETISVRT VCGYYTSAGT YGLDSVKKKC LEWLLNNLMT HQSVELFKEL
260 270 280 290 300
SINVMKQLIG SSNLFVMQVE MDVYTALKKW MFLQLVPSWN GSLKQLLTET
310 320 330 340 350
DVWFSKWKKD FEGTTFLETE QGKPFAPVFR HLRLQYIISD LASARIIEQD
360 370 380 390 400
SLVPSEWLAA VYKQQWLAML RAEQDSEVGP QEINKEELEG NSMRCGRKLA
410 420 430 440 450
KDGEYCWRWT GFNFGFDLLV TYTNRYIIFK RNTLNQPCSG SVSLQPRRSI
460 470 480 490 500
AFRLRLASFD SSGKLICSRA TGYQILTLEK DQEQVVMNLD SRLLIFPLYI
510 520
CCNFLYISPE KRTESNRHPE NPGH
Length:524
Mass (Da):59,654
Last modified:May 24, 2004 - v2
Checksum:i3DCC974A758D14C3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3V0Z2Q3V0Z2_MOUSE
Germ cell-less protein-like 1
Gmcl1 Gcl
199Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151P → L in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti177S → N in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti192D → N in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti198C → W in AAK69515 (PubMed:11591818).Curated1
Sequence conflicti386E → G in BAB23499 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163665 mRNA Translation: AAD52204.1
AF186095 mRNA Translation: AAF01415.1
AF282322 mRNA Translation: AAK69515.1
AK004716 mRNA Translation: BAB23499.1
BC054767 mRNA Translation: AAH54767.1
CCDSiCCDS20316.1
PIRiJC7090
RefSeqiNP_035948.3, NM_011818.3
UniGeneiMm.321452

Genome annotation databases

EnsembliENSMUST00000001185; ENSMUSP00000001185; ENSMUSG00000001157
GeneIDi23885
KEGGimmu:23885
UCSCiuc009csl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163665 mRNA Translation: AAD52204.1
AF186095 mRNA Translation: AAF01415.1
AF282322 mRNA Translation: AAK69515.1
AK004716 mRNA Translation: BAB23499.1
BC054767 mRNA Translation: AAH54767.1
CCDSiCCDS20316.1
PIRiJC7090
RefSeqiNP_035948.3, NM_011818.3
UniGeneiMm.321452

3D structure databases

ProteinModelPortaliQ920G9
SMRiQ920G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204775, 5 interactors
DIPiDIP-24259N
STRINGi10090.ENSMUSP00000001185

PTM databases

iPTMnetiQ920G9
PhosphoSitePlusiQ920G9

Proteomic databases

EPDiQ920G9
MaxQBiQ920G9
PaxDbiQ920G9
PRIDEiQ920G9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001185; ENSMUSP00000001185; ENSMUSG00000001157
GeneIDi23885
KEGGimmu:23885
UCSCiuc009csl.2 mouse

Organism-specific databases

CTDi64395
MGIiMGI:1345156 Gmcl1

Phylogenomic databases

eggNOGiKOG4682 Eukaryota
ENOG410XPEJ LUCA
GeneTreeiENSGT00390000003212
HOGENOMiHOG000232133
HOVERGENiHBG051741
InParanoidiQ920G9
KOiK10485
OMAiGAFCYCH
OrthoDBiEOG091G07ZV
PhylomeDBiQ920G9
TreeFamiTF316048

Miscellaneous databases

PROiPR:Q920G9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001157 Expressed in 272 organ(s), highest expression level in testis
CleanExiMM_GMCL1
ExpressionAtlasiQ920G9 baseline and differential
GenevisibleiQ920G9 MM

Family and domain databases

InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGMCL1_MOUSE
AccessioniPrimary (citable) accession number: Q920G9
Secondary accession number(s): Q9DBW5, Q9QUP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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