Caspase 9

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cysteine-type endopeptidase activity Source: RGD
• cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: RGD
• cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cysteine-type peptidase activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures."
    Li T., Fan Y., Luo Y., Xiao B., Lu C.
    Exp Neurol 197:301-308(2006) [PubMed] [Europe PMC] [Abstract]
  • "Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis."
    Haidara K., Marion M., Gascon-Barre M., Denizeau F., Averill-Bates D.A.
    Toxicol Appl Pharmacol 229:65-76(2008) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGD
• peptidase activity Source: RGD
• protein kinase binding Source: RGD
• SH3 domain binding Source: RGD

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle."
    Chung L., Ng Y.C.
    Biochim Biophys Acta 1762:103-109(2006) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells."
    Song Y., Liang X., Hu Y., Wang Y., Yu H., Yang K.
    Toxicology 253:53-61(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to dexamethasone stimulus Source: RGD
• cellular response to DNA damage stimulus Source: RGD
• cellular response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo."
    Tsai N.M., Chen Y.L., Lee C.C., Lin P.C., Cheng Y.L., Chang W.L., Lin S.Z., Harn H.J.
    J Neurochem 99:1251-1262(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV Source: RGD
• glial cell apoptotic process Source: RGDInferred from expression patternⁱ
  • "Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation."
    Bhattacharjee M., Acharya S., Ghosh A., Sarkar P., Chatterjee S., Kumar P., Chaudhuri S.
    Int Immunol 20:1489-1505(2008) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway in response to DNA damage Source: RGD
• kidney development Source: RGDInferred from expression patternⁱ
  • "Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related Proteins in Rat Renal Proximal Tubules during Development."
    Song X.F., Tian H., Zhang P., Zhang Z.X.
    Nephron 135:77-86(2017) [PubMed] [Europe PMC] [Abstract]
• leukocyte apoptotic process Source: RGDInferred from expression patternⁱ
  • "Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells."
    Yin H., Ye X., Niu Q., Wang C., Li Y.
    Lasers Med Sci 31:817-824(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage."
    Tabuchi K., Pak K., Chavez E., Ryan A.F.
    Neuroscience 149:213-222(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron apoptotic process Source: RGD
• proteolysis Source: RGDInferred from direct assayⁱ
  • "Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis."
    Haidara K., Marion M., Gascon-Barre M., Denizeau F., Averill-Bates D.A.
    Toxicol Appl Pharmacol 229:65-76(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of response to DNA damage stimulus Source: RGD
• response to antibiotic Source: RGDInferred from expression patternⁱ
  • "[Apoptosis of type II alveolar epithelial cell induced by bleomycin in lung fibrotic rat]."
    Kong L., Gao Y.Q., Wang J.F., Niu J.Z., Zhang X.X.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 29:782-786(2007) [PubMed] [Europe PMC] [Abstract]
• response to cobalt ion Source: RGDInferred from expression patternⁱ
  • "Estradiol protects PC12 cells against CoCl2-induced apoptosis."
    Jung J.Y., Roh K.H., Jeong Y.J., Kim S.H., Lee E.J., Kim M.S., Oh W.M., Oh H.K., Kim W.J.
    Brain Res Bull 76:579-585(2008) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estradiol protects PC12 cells against CoCl2-induced apoptosis."
    Jung J.Y., Roh K.H., Jeong Y.J., Kim S.H., Lee E.J., Kim M.S., Oh W.M., Oh H.K., Kim W.J.
    Brain Res Bull 76:579-585(2008) [PubMed] [Europe PMC] [Abstract]
• response to ischemia Source: RGDInferred from expression patternⁱ
  • "Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury."
    Scarabelli T.M., Stephanou A., Pasini E., Comini L., Raddino R., Knight R.A., Latchman D.S.
    Circ Res 90:745-748(2002) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: RGDInferred from expression patternⁱ
  • "Caspase activation in fetal rat brain following experimental intrauterine inflammation."
    Sharangpani A., Takanohashi A., Bell M.J.
    Brain Res 1200:138-145(2008) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from direct assayⁱ
  • "Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination."
    Malejka-Giganti D., Parkin D.R., Bennett K.K., Lu Y., Decker R.W., Niehans G.A., Bliss R.L.
    Eur J Cancer Prev 16:130-141(2007) [PubMed] [Europe PMC] [Abstract]
• response to UV Source: RGD
• signal transduction in response to DNA damage Source: RGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD
• protein kinase binding Source: RGD
• SH3 domain binding Source: RGD

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEEADRQLLR RCRVRLVREL QVAELWDALL SRELFTRDMI EDIQRAGSGS 
        60         70         80         90        100
RRDQARQLVI DLETRGRQAL PRFISCLEDT GQGSLASFLQ SSGQAAKQDP 
       110        120        130        140        150
EAVTPLDHLV PVVLGPMGLK SKEQKVVKLD PSQPALGNLT PVVLGPEELW 
       160        170 
PTRLRPEVLT PETPRPVDIG SGRAHDV                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ