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Protein

Sialic acid-binding Ig-like lectin 5

Gene

Siglec5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114Sialic acidBy similarity1
Binding sitei120Sialic acidBy similarity1
Binding sitei122Sialic acidBy similarity1

GO - Molecular functioni

  • monosaccharide binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 5
Short name:
Siglec-5
Alternative name(s):
Sialic acid-binding Ig-like lectin F
Short name:
Siglec-F
Short name:
mSiglec-F
CD_antigen: CD170
Gene namesi
Name:Siglec5
Synonyms:Siglecf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2681107 Siglec5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 439ExtracellularSequence analysisAdd BLAST423
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 569CytoplasmicSequence analysisAdd BLAST109

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001494517 – 569Sialic acid-binding Ig-like lectin 5Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 163PROSITE-ProRule annotation
Disulfide bondi40 ↔ 96PROSITE-ProRule annotation
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 206PROSITE-ProRule annotation
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 308PROSITE-ProRule annotation
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ920G3
PaxDbiQ920G3
PRIDEiQ920G3

PTM databases

iPTMnetiQ920G3
PhosphoSitePlusiQ920G3

Expressioni

Tissue specificityi

Predominantly expressed by immature monocytic/myeloid lineage cells in bone marrow. Also found at lower levels in mature neutrophils and monocytes.

Gene expression databases

BgeeiENSMUSG00000039013 Expressed in 71 organ(s), highest expression level in bone marrow
CleanExiMM_SIGLEC5
ExpressionAtlasiQ920G3 baseline and differential
GenevisibleiQ920G3 MM

Interactioni

Protein-protein interaction databases

IntActiQ920G3, 4 interactors
STRINGi10090.ENSMUSP00000012798

Structurei

3D structure databases

ProteinModelPortaliQ920G3
SMRiQ920G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 116Ig-like V-typeAdd BLAST99
Domaini139 – 224Ig-like C2-type 1Add BLAST86
Domaini229 – 324Ig-like C2-type 2Add BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi536 – 541ITIM motif6
Motifi559 – 564SLAM-like motif6

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJT6 Eukaryota
ENOG410YKZU LUCA
GeneTreeiENSGT00760000119139
HOGENOMiHOG000236324
HOVERGENiHBG036161
InParanoidiQ920G3
KOiK06549
OMAiISWTRES
OrthoDBiEOG091G0702
PhylomeDBiQ920G3
TreeFamiTF332441

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q920G3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWAWLLPLL WAGCLATDGY SLSVTGSVTV QEGLCVFVAC QVQYPNSKGP
60 70 80 90 100
VFGYWFREGA NIFSGSPVAT NDPQRSVLKE AQGRFYLMGK ENSHNCSLDI
110 120 130 140 150
RDAQKIDTGT YFFRLDGSVK YSFQKSMLSV LVIALTEVPN IQVTSTLVSG
160 170 180 190 200
NSTKLLCSVP WACEQGTPPI FSWMSSALTS LGHRTTLSSE LNLTPRPQDN
210 220 230 240 250
GTNLTCQVNL PGTGVTVERT QQLSVIYAPQ KMTIRVSWGD DTGTKVLQSG
260 270 280 290 300
ASLQIQEGES LSLVCMADSN PPAVLSWERP TQKPFQLSTP AELQLPRAEL
310 320 330 340 350
EDQGKYICQA QNSQGAQTAS VSLSIRSLLQ LLGPSCSFEG QGLHCSCSSR
360 370 380 390 400
AWPAPSLRWR LGEGVLEGNS SNGSFTVKSS SAGQWANSSL ILSMEFSSNH
410 420 430 440 450
RLSCEAWSDN RVQRATILLV SGPKVSQAGK SETSRGTVLG AIWGAGLMAL
460 470 480 490 500
LAVCLCLIFF TVKVLRKKSA LKVAATKGNH LAKNPASTIN SASITSSNIA
510 520 530 540 550
LGYPIQGHLN EPGSQTQKEQ PPLATVPDTQ KDEPELHYAS LSFQGPMPPK
560
PQNTEAMKSV YTEIKIHKC
Length:569
Mass (Da):61,476
Last modified:December 1, 2001 - v1
Checksum:i8093838090484FC1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZE2Q80ZE2_MOUSE
Sialic acid-binding Ig-like lectin ...
Siglecf Siglec5
523Annotation score:
B7ZN64B7ZN64_MOUSE
Sialic acid-binding Ig-like lectin ...
Siglecf Siglec5
535Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293371 mRNA Translation: AAL11043.1
CCDSiCCDS21167.1
RefSeqiNP_001257948.1, NM_001271019.1
NP_663556.1, NM_145581.2
UniGeneiMm.290569

Genome annotation databases

EnsembliENSMUST00000012798; ENSMUSP00000012798; ENSMUSG00000039013
ENSMUST00000122423; ENSMUSP00000113245; ENSMUSG00000039013
GeneIDi233186
KEGGimmu:233186
UCSCiuc009gml.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-F

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293371 mRNA Translation: AAL11043.1
CCDSiCCDS21167.1
RefSeqiNP_001257948.1, NM_001271019.1
NP_663556.1, NM_145581.2
UniGeneiMm.290569

3D structure databases

ProteinModelPortaliQ920G3
SMRiQ920G3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920G3, 4 interactors
STRINGi10090.ENSMUSP00000012798

PTM databases

iPTMnetiQ920G3
PhosphoSitePlusiQ920G3

Proteomic databases

MaxQBiQ920G3
PaxDbiQ920G3
PRIDEiQ920G3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012798; ENSMUSP00000012798; ENSMUSG00000039013
ENSMUST00000122423; ENSMUSP00000113245; ENSMUSG00000039013
GeneIDi233186
KEGGimmu:233186
UCSCiuc009gml.2 mouse

Organism-specific databases

CTDi233186
MGIiMGI:2681107 Siglec5

Phylogenomic databases

eggNOGiENOG410IJT6 Eukaryota
ENOG410YKZU LUCA
GeneTreeiENSGT00760000119139
HOGENOMiHOG000236324
HOVERGENiHBG036161
InParanoidiQ920G3
KOiK06549
OMAiISWTRES
OrthoDBiEOG091G0702
PhylomeDBiQ920G3
TreeFamiTF332441

Miscellaneous databases

PROiPR:Q920G3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039013 Expressed in 71 organ(s), highest expression level in bone marrow
CleanExiMM_SIGLEC5
ExpressionAtlasiQ920G3 baseline and differential
GenevisibleiQ920G3 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSIGL5_MOUSE
AccessioniPrimary (citable) accession number: Q920G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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