Mlycd

Functionⁱ

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.3 Publications

Catalytic activityⁱ

Malonyl-CoA = acetyl-CoA + CO₂.3 Publications

Activity regulationⁱ

Malonyl-CoA decarboxylase activity does not require any cofactors or divalent metal ions.By similarity

Kineticsⁱ

K_M=
0.36 mM for malonyl-CoA
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Rat malonyl-CoA decarboxylase; cloning, expression in E. coli and its biochemical characterization."
  Lee G.Y., Bahk Y.Y., Kim Y.S.
  J. Biochem. Mol. Biol. 35:213-219(2002) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL), CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.

Pathwayⁱ: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from malonyl-CoA.
Proteins known to be involved in this subpathway in this organism are:

Malonyl-CoA decarboxylase, mitochondrial (Mlycd)

This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from malonyl-CoA, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	210	Essential for catalytic activity	1
Active siteⁱ	328	Proton acceptorBy similarity	1
Binding siteⁱ	328	Malonyl-CoABy similarity	1
Active siteⁱ	422	Proton donorBy similarity	1
Binding siteⁱ	422	Malonyl-CoABy similarity	1

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
malonyl-CoA decarboxylase activity
Source: RGD
Inferred from direct assayⁱ
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acetyl-CoA biosynthetic process
Source: RGD
Inferred from direct assayⁱ
- 17316539
fatty acid biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15105298
fatty acid oxidation
Source: RGD
Inferred from direct assayⁱ
- 17316539
malonyl-CoA catabolic process Source: UniProtKB
positive regulation of fatty acid oxidation Source: UniProtKB
regulation of fatty acid beta-oxidation
Source: RGD
Inferred from direct assayⁱ
- 10516138
regulation of fatty acid oxidation
Source: RGD
Inferred from mutant phenotypeⁱ
- 15105298
regulation of glucose metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15105298
response to ischemia
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15105298

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390247 Beta-oxidation of very long chain fatty acids R-RNO-9033241 Peroxisomal protein import
SABIO-RKⁱ	Q920F5
UniPathwayⁱ	UPA00340;UER00710

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Malonyl-CoA decarboxylase, mitochondrial (EC:4.1.1.9) Short name: MCD
Gene namesⁱ	Name:Mlycd
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 19

Organism-specific databases

Rat genome database More...RGDⁱ	620234 Mlycd

RGDⁱ

620234 Mlycd

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Peroxisome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	210	K → M: Abolishes catalytic activity. 1 Publication	1
Mutagenesisⁱ	308	K → M: 40% reduction in catalytic activity. 1 Publication	1
Mutagenesisⁱ	388	K → M: 40% reduction in catalytic activity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 38	MitochondrionSequence analysisAdd BLAST		38
ChainⁱPRO_0000021092	39 – 492	Malonyl-CoA decarboxylase, mitochondrialAdd BLAST		454

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	58	N6-acetyllysine1 Publication	1
Modified residueⁱ	167	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	167	N6-succinyllysine; alternateBy similarity	1
Disulfide bondⁱ	205	InterchainSequence analysis
Modified residueⁱ	210	N6-acetyllysine1 Publication	1
Modified residueⁱ	221	N6-succinyllysineBy similarity	1
Modified residueⁱ	316	N6-acetyllysine1 Publication	1
Modified residueⁱ	385	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	385	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	388	N6-acetyllysine1 Publication	1
Modified residueⁱ	441	N6-acetyllysine1 Publication	1
Modified residueⁱ	471	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Acetylation at Lys-471 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-471 by SIRT4 represses activity, leading to promote lipogenesis (By similarity).By similarity

Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria.Curated

Keywords - PTMⁱ

Acetylation, Disulfide bond

Proteomic databases

PaxDbⁱ	Q920F5
PRIDEⁱ	Q920F5

PTM databases

iPTMnetⁱ	Q920F5
PhosphoSitePlusⁱ	Q920F5

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, heart, skeletal muscles and adipose tissues (at protein level). Ubiquitous. Strongly expressed in liver, kidney, heart, skeletal muscle and adipose tissues. Weakly expressed in brain.4 Publications

Gene expression databases

Bgeeⁱ	ENSRNOG00000014522 Expressed in 10 organ(s), highest expression level in heart
Genevisibleⁱ	Q920F5 RN

Interactionⁱ

Subunit structureⁱ

Homotetramer. Dimer of dimers. The two subunits within a dimer display conformational differences suggesting that at any given moment, only one of the two subunits is competent for malonyl-CoA binding and catalytic activity. Under oxidizing conditions, can form disulfide-linked homotetramers (in vitro). Associates with the peroxisomal targeting signal receptor PEX5 (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000019923

STRINGⁱ

10116.ENSRNOP00000019923

Structureⁱ

3D structure databases

SMRⁱ	Q920F5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	39 – 189	Alpha-helical domainBy similarityAdd BLAST	151
Regionⁱ	190 – 492	Catalytic domainBy similarityAdd BLAST	303
Regionⁱ	298 – 304	Malonyl-CoA bindingBy similarity	7

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	490 – 492	Microbody targeting signalSequence analysis		3

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3018 Eukaryota COG1593 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005410
HOGENOMⁱ	HOG000141409
HOVERGENⁱ	HBG000825
InParanoidⁱ	Q920F5
KEGG Orthology (KO) More...KOⁱ	K01578
OMAⁱ	TGSCGLM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07WG
PhylomeDBⁱ	Q920F5
TreeFamⁱ	TF312959

Family and domain databases

Gene3Dⁱ	1.20.140.90, 1 hit
InterProⁱ	View protein in InterPro IPR038917 Malonyl_CoA_deC IPR007956 Malonyl_CoA_deC_C IPR035372 MCD_N IPR038351 MCD_N_sf
PANTHERⁱ	PTHR28641 PTHR28641, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05292 MCD, 1 hit PF17408 MCD_N, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

Note: According to PubMed:10229677, a single transcription start site has been demonstrated.

Isoform Mitochondrial (identifier: Q920F5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGLGPSLRA RRLLPLRYPP RPPGPRGPRL CSGLTASAMD ELLRRAVPPT 
        60         70         80         90        100
PAYELREKTP APAEGQCADF VSFYGGLAEA AQRAELLGRL AQGFGVDHGQ 
       110        120        130        140        150
VAEQSAGVLQ LRQQSREAAV LLQAEDRLRY ALVPRYRGLF HHISKLDGGV 
       160        170        180        190        200
RFLVQLRADL LEAQALKLVE GPHVREMNGV LKSMLSEWFS SGFLNLERVT 
       210        220        230        240        250
WHSPCEVLQK ISECEAVHPV KNWMDMKRRV GPYRRCYFFS HCSTPGDPLV 
       260        270        280        290        300
VLHVALTGDI SNNIQSIVKE CPPSETEEKN RIAAAVFYSI SLTQQGLQGV 
       310        320        330        340        350
ELGTFLIKRV VKELQKEFPH LGAFSSLSPI PGFTKWLLGL LNVQGKEYGR 
       360        370        380        390        400
NELFTDSECK EIAEVTGDPV HESLKGLLSS GEWAKSEKLA QALQGPLMRL 
       410        420        430        440        450
CAWYLYGEKH RGYALNPVAN FHLQNGAVMW RINWMADSSL KGLTSSCGLM 
       460        470        480        490 
VNYRYYLEET GPNSISYLGS KNIKASEQIL SLVAQFQSNS KL

Length:492

Mass (Da):54,762

Last modified:December 1, 2001 - v1

Checksum:ⁱD1FB65533B5A582E

GO

Isoform Cytoplasmic+peroxisomal (identifier: Q920F5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: Missing.

« Hide

        10         20         30         40         50
MDELLRRAVP PTPAYELREK TPAPAEGQCA DFVSFYGGLA EAAQRAELLG 
        60         70         80         90        100
RLAQGFGVDH GQVAEQSAGV LQLRQQSREA AVLLQAEDRL RYALVPRYRG 
       110        120        130        140        150
LFHHISKLDG GVRFLVQLRA DLLEAQALKL VEGPHVREMN GVLKSMLSEW 
       160        170        180        190        200
FSSGFLNLER VTWHSPCEVL QKISECEAVH PVKNWMDMKR RVGPYRRCYF 
       210        220        230        240        250
FSHCSTPGDP LVVLHVALTG DISNNIQSIV KECPPSETEE KNRIAAAVFY 
       260        270        280        290        300
SISLTQQGLQ GVELGTFLIK RVVKELQKEF PHLGAFSSLS PIPGFTKWLL 
       310        320        330        340        350
GLLNVQGKEY GRNELFTDSE CKEIAEVTGD PVHESLKGLL SSGEWAKSEK 
       360        370        380        390        400
LAQALQGPLM RLCAWYLYGE KHRGYALNPV ANFHLQNGAV MWRINWMADS 
       410        420        430        440        450
SLKGLTSSCG LMVNYRYYLE ETGPNSISYL GSKNIKASEQ ILSLVAQFQS 

NSKL

Note: May be produced by alternative initiation at Met-39 of isoform mitochondrial. Alternatively, represents a proteolytic processed form of the mitochondrial form (PubMed:10947976).1 Publication

Show »

Length:454

Mass (Da):50,685

Checksum:ⁱ92D3679A358E332B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	213	E → D in CAB46681 (PubMed:10229677).Curated	1
Sequence conflictⁱ	218	H → Q in CAB46681 (PubMed:10229677).Curated	1
Sequence conflictⁱ	301	E → G in CAB46681 (PubMed:10229677).Curated	1
Sequence conflictⁱ	412	Missing in CAB46681 (PubMed:10229677).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018818	1 – 38	Missing in isoform Cytoplasmic+peroxisomal. CuratedAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007704 mRNA Translation: CAB46681.1 AF304865 mRNA Translation: AAL09352.1 BC061845 mRNA Translation: AAH61845.1
NCBI Reference Sequences More...RefSeqⁱ	NP_445929.1, NM_053477.1
UniGeneⁱ	Rn.13468

Genome annotation databases

Ensemblⁱ	ENSRNOT00000019923; ENSRNOP00000019923; ENSRNOG00000014522 [Q920F5-1]
GeneIDⁱ	85239
KEGGⁱ	rno:85239
UCSC genome browser More...UCSCⁱ	RGD:620234 rat [Q920F5-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q920F5	Isoform Cytoplasmic+peroxisomal of Malonyl-CoA decarboxylase, mitochondrial		RAT		454	UniRef100_Q920F5
Malonyl-CoA decarboxylase (Fragment)		RAT		21

Protein	Similar proteins		Species	Score	Length	Source
Q920F5	Isoform Cytoplasmic+peroxisomal of Malonyl-CoA decarboxylase, mitochondrial		RAT		454	UniRef90_Q920F5
Uncharacterized protein		NEOLE		492
malonyl-CoA decarboxylase, mitochondrial		MESAU		492
UPI0003330A4D		JACJA		500
Malonyl-CoA decarboxylase (Fragment)		RAT		21

Protein	Similar proteins		Species	Score	Length	Source
Q920F5	Malonyl-CoA decarboxylase, mitochondrial	)	HUMAN		493	UniRef50_O95822
Malonyl-CoA decarboxylase, mitochondrial		MOUSE		492
Malonyl-CoA decarboxylase, mitochondrial		ANSAN		504
Malonyl-CoA decarboxylase		PANTR		493
Uncharacterized protein		CERAT		493
+248

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ007704 mRNA Translation: CAB46681.1 AF304865 mRNA Translation: AAL09352.1 BC061845 mRNA Translation: AAH61845.1
RefSeqⁱ	NP_445929.1, NM_053477.1
UniGeneⁱ	Rn.13468

3D structure databases

SMRⁱ	Q920F5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000019923

STRINGⁱ

10116.ENSRNOP00000019923

PTM databases

iPTMnetⁱ	Q920F5
PhosphoSitePlusⁱ	Q920F5

Proteomic databases

PaxDbⁱ	Q920F5
PRIDEⁱ	Q920F5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000019923; ENSRNOP00000019923; ENSRNOG00000014522 [Q920F5-1]
GeneIDⁱ	85239
KEGGⁱ	rno:85239
UCSCⁱ	RGD:620234 rat [Q920F5-1]

Organism-specific databases

CTDⁱ	23417
RGDⁱ	620234 Mlycd

Phylogenomic databases

eggNOGⁱ	KOG3018 Eukaryota COG1593 LUCA
GeneTreeⁱ	ENSGT00390000005410
HOGENOMⁱ	HOG000141409
HOVERGENⁱ	HBG000825
InParanoidⁱ	Q920F5
KOⁱ	K01578
OMAⁱ	TGSCGLM
OrthoDBⁱ	EOG091G07WG
PhylomeDBⁱ	Q920F5
TreeFamⁱ	TF312959

Enzyme and pathway databases

UniPathwayⁱ	UPA00340;UER00710
Reactomeⁱ	R-RNO-390247 Beta-oxidation of very long chain fatty acids R-RNO-9033241 Peroxisomal protein import
SABIO-RKⁱ	Q920F5

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q920F5

PROⁱ

PR:Q920F5

Gene expression databases

Bgeeⁱ	ENSRNOG00000014522 Expressed in 10 organ(s), highest expression level in heart
Genevisibleⁱ	Q920F5 RN

Family and domain databases

Gene3Dⁱ	1.20.140.90, 1 hit
InterProⁱ	View protein in InterPro IPR038917 Malonyl_CoA_deC IPR007956 Malonyl_CoA_deC_C IPR035372 MCD_N IPR038351 MCD_N_sf
PANTHERⁱ	PTHR28641 PTHR28641, 1 hit
Pfamⁱ	View protein in Pfam PF05292 MCD, 1 hit PF17408 MCD_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCMC_RAT
Accessionⁱ	Q920F5Primary (citable) accession number: Q920F5 Secondary accession number(s): Q9WUY2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - Q920F5 (DCMC_RAT)

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Malonyl-CoA decarboxylase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: acetyl-CoA biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Mitochondrion

Other locations

Cytosol

Mitochondrion

Peroxisome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: acetyl-CoA biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ