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Protein

Secretoglobin family 3A member 1

Gene

Scgb3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Secreted cytokine-like protein. Inhibits cell growth in vitro.By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of myoblast fusion Source: MGI

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 3A member 1
Alternative name(s):
Cytokine HIN-1
High in normal 1
Pneumo secretory protein 2
Short name:
PnSP-2
Uteroglobin-related protein 2
Gene namesi
Name:Scgb3a1
Synonyms:Hin1, Pnsp2, Ugrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915912 Scgb3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003638422 – 104Secretoglobin family 3A member 1Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ920D7
PaxDbiQ920D7
PRIDEiQ920D7

Expressioni

Tissue specificityi

Highly expressed in lung, where it localizes to epithelial cells lining the trachea and bronchi (PubMed:12406855, PubMed:12175512). Expression in lung is mainly restricted to bronchi, submucosal glands of the trachea, and tracheal epithelium, with little expression in terminal bronchioles (PubMed:12406855). Expressed in uterus where it localizes to epithelial cells of the uterine glands (PubMed:12175512). Also detected in heart, stomach and small intestine (PubMed:12175512).2 Publications

Developmental stagei

Detected in lung at embryonic stage E18.5. During gestation, expressed in the mammary gland from 6.5 days post coitum (dpc) with highest expression at 10.5 dpc. Expression then declines, but later increases again during mammary gland involution at 4-21 days post partum.1 Publication

Gene expression databases

BgeeiENSMUSG00000064057 Expressed in 68 organ(s), highest expression level in trachea
CleanExiMM_SCGB3A1
ExpressionAtlasiQ920D7 baseline and differential
GenevisibleiQ920D7 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043325

Structurei

3D structure databases

SMRiQ920D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the secretoglobin family. UGRP subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J536 Eukaryota
ENOG4111BGJ LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ920D7
OMAiFNPLKFM
OrthoDBiEOG091G18VS
PhylomeDBiQ920D7
TreeFamiTF336928

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q920D7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLTTTFLVL CVALLSDSGV AFFMDSLAKP AVEPVAALAP AAEAVAGAVP
60 70 80 90 100
SLPLSHLAIL RFILASMGIP LDPLIEGSRK CVTELGPEAV GAVKSLLGVL

TMFG
Length:104
Mass (Da):10,591
Last modified:December 1, 2001 - v1
Checksum:iD62F0E601FB57A6D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CJC6Q8CJC6_MOUSE
Secretoglobin family 3A member 1
Scgb3a1 mCG_125225
94Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313456 mRNA Translation: AAL26216.1
AF436840 mRNA Translation: AAQ04482.1
CCDSiCCDS24619.1
RefSeqiNP_473378.1, NM_054037.2
UniGeneiMm.22802

Genome annotation databases

EnsembliENSMUST00000043873; ENSMUSP00000043325; ENSMUSG00000064057
GeneIDi68662
KEGGimmu:68662
UCSCiuc007iqw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313456 mRNA Translation: AAL26216.1
AF436840 mRNA Translation: AAQ04482.1
CCDSiCCDS24619.1
RefSeqiNP_473378.1, NM_054037.2
UniGeneiMm.22802

3D structure databases

SMRiQ920D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043325

Proteomic databases

MaxQBiQ920D7
PaxDbiQ920D7
PRIDEiQ920D7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043873; ENSMUSP00000043325; ENSMUSG00000064057
GeneIDi68662
KEGGimmu:68662
UCSCiuc007iqw.2 mouse

Organism-specific databases

CTDi92304
MGIiMGI:1915912 Scgb3a1

Phylogenomic databases

eggNOGiENOG410J536 Eukaryota
ENOG4111BGJ LUCA
GeneTreeiENSGT00420000029848
HOGENOMiHOG000128185
HOVERGENiHBG079305
InParanoidiQ920D7
OMAiFNPLKFM
OrthoDBiEOG091G18VS
PhylomeDBiQ920D7
TreeFamiTF336928

Miscellaneous databases

PROiPR:Q920D7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064057 Expressed in 68 organ(s), highest expression level in trachea
CleanExiMM_SCGB3A1
ExpressionAtlasiQ920D7 baseline and differential
GenevisibleiQ920D7 MM

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSG3A1_MOUSE
AccessioniPrimary (citable) accession number: Q920D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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