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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

Ms4a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP) (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:Ms4a3
Synonyms:Htm4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2158468 Ms4a3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 58ExtracellularSequence analysisAdd BLAST11
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 97CytoplasmicSequence analysisAdd BLAST18
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 148ExtracellularSequence analysisAdd BLAST30
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 213CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586331 – 213Membrane-spanning 4-domains subfamily A member 3Add BLAST213

Proteomic databases

PaxDbiQ920C4
PRIDEiQ920C4

PTM databases

PhosphoSitePlusiQ920C4

Expressioni

Tissue specificityi

Expressed at low levels only in specific immune tissues, such as, spleen, bone marrow and peripheral blood leukocytes.

Gene expression databases

BgeeiENSMUSG00000024681 Expressed in 38 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ920C4 baseline and differential
GenevisibleiQ920C4 MM

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108608

Structurei

3D structure databases

ProteinModelPortaliQ920C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 64Poly-Phe6

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.By similarity

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZNT Eukaryota
ENOG411140Q LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000113657
HOVERGENiHBG052512
InParanoidiQ920C4
KOiK22190
OMAiPIWGAVF
OrthoDBiEOG091G0IBB
PhylomeDBiQ920C4
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequencei

Sequence statusi: Complete.

Q920C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPEETGGSV YQPLDESRHV QRGVLQALGA IQILNGILIL ALGIFLVCLQ
60 70 80 90 100
HVSHHFRHFF FFTFYTGYPL WGAVFFISSG SLTVAAGRNP TRMLMQNSFG
110 120 130 140 150
INIASTTIAF VGTVFLSVHL AFNTQAFKGC QSSPSPDVCI SLGSSSDGLV
160 170 180 190 200
SLMLILTLLE LSVTISISAM WCLGNVCGLR EAITSPPNSV ESGILPEGSD
210
SENLNTQPQA SEE
Length:213
Mass (Da):22,872
Last modified:December 1, 2001 - v1
Checksum:iA3C0A60F602C2BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA Translation: AAL16955.1
AK036464 mRNA Translation: BAC29440.1
AF280401 mRNA Translation: AAK37993.1
CCDSiCCDS29605.1
RefSeqiNP_573509.1, NM_133246.5
UniGeneiMm.240438

Genome annotation databases

EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681
ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681
GeneIDi170813
KEGGimmu:170813
UCSCiuc008gsp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321128 mRNA Translation: AAL16955.1
AK036464 mRNA Translation: BAC29440.1
AF280401 mRNA Translation: AAK37993.1
CCDSiCCDS29605.1
RefSeqiNP_573509.1, NM_133246.5
UniGeneiMm.240438

3D structure databases

ProteinModelPortaliQ920C4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108608

PTM databases

PhosphoSitePlusiQ920C4

Proteomic databases

PaxDbiQ920C4
PRIDEiQ920C4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112984; ENSMUSP00000108608; ENSMUSG00000024681
ENSMUST00000186023; ENSMUSP00000140508; ENSMUSG00000024681
GeneIDi170813
KEGGimmu:170813
UCSCiuc008gsp.2 mouse

Organism-specific databases

CTDi932
MGIiMGI:2158468 Ms4a3

Phylogenomic databases

eggNOGiENOG410IZNT Eukaryota
ENOG411140Q LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000113657
HOVERGENiHBG052512
InParanoidiQ920C4
KOiK22190
OMAiPIWGAVF
OrthoDBiEOG091G0IBB
PhylomeDBiQ920C4
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q920C4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024681 Expressed in 38 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ920C4 baseline and differential
GenevisibleiQ920C4 MM

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMS4A3_MOUSE
AccessioniPrimary (citable) accession number: Q920C4
Secondary accession number(s): Q99MX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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