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Protein

Fc receptor-like A

Gene

Fcrla

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be implicated in B-cell differentiation and lymphomagenesis.

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name:
FcRX
Gene namesi
Name:Fcrla
Synonyms:Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138647 Fcrla

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000022793631 – 352Fc receptor-like AAdd BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi109 ↔ 153PROSITE-ProRule annotation
Disulfide bondi202 ↔ 250PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ920A9
PaxDbiQ920A9
PRIDEiQ920A9

PTM databases

iPTMnetiQ920A9
PhosphoSitePlusiQ920A9

Expressioni

Tissue specificityi

Highly expressed in spleen. Expressed in immature B-cell and B-cell lines.1 Publication

Gene expression databases

BgeeiENSMUSG00000038421 Expressed in 78 organ(s), highest expression level in bone marrow
CleanExiMM_FCRL1
MM_FCRLA
ExpressionAtlasiQ920A9 baseline and differential
GenevisibleiQ920A9 MM

Interactioni

Subunit structurei

Monomer or homodimer; disulfide-linked.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Traf2P394295EBI-646587,EBI-520016

Protein-protein interaction databases

IntActiQ920A9, 1 interactor
STRINGi10090.ENSMUSP00000036380

Structurei

3D structure databases

ProteinModelPortaliQ920A9
SMRiQ920A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 169Ig-like C2-type 1Add BLAST90
Domaini182 – 260Ig-like C2-type 2Add BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi289 – 294Poly-Pro6

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHSR Eukaryota
ENOG4111EGY LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG059243
InParanoidiQ920A9
OMAiPPGPNKE
OrthoDBiEOG091G0ETN
PhylomeDBiQ920A9
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q920A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLSCTLTQW ALYVCPAVLL ATQMLLAASS ETLKCEGLVS TEQGSCQAAA
60 70 80 90 100
EEDEGDEDDG DMTQSSEAGF QFKGYTFSKP FHLSVSYDWL ILQGPATLIF
110 120 130 140 150
EGDTLVLHCR AWQDWPLTQV IFYREGSALG PPGPKSEFSI TMVQKSDGGH
160 170 180 190 200
YHCSGIFRSP GPGSREAASP VAITVQELFA APVLKALPSS EPQEGGSVTL
210 220 230 240 250
SCQTKLALQR SASRLLFSFY KDGRSLSVRG VSSELKIPKA SEEHSGSYWC
260 270 280 290 300
EAVTEDRQIS KQSPQLEIWV QALQKPTASE TPPTEALGPL PPPPASSAEQ
310 320 330 340 350
PRFSSPDPHL HHQMQLLLKQ IQDVRALLGH LVMELRDLSV YLKPGTTKVA

DK
Length:352
Mass (Da):38,348
Last modified:December 1, 2001 - v1
Checksum:i68836C3C2B6077B7
GO
Isoform 2 (identifier: Q920A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: A → AA

Show »
Length:353
Mass (Da):38,420
Checksum:i6FAB4687B4E92B3C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CX78E0CX78_MOUSE
Fc receptor-like A
Fcrla
216Annotation score:
F7DEW9F7DEW9_MOUSE
Fc receptor-like A
Fcrla
177Annotation score:
E0CY58E0CY58_MOUSE
Fc receptor-like A
Fcrla
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Missing in BAE42968 (PubMed:16141072).Curated1
Sequence conflicti22T → I in BAE42968 (PubMed:16141072).Curated1
Sequence conflicti30S → L in BAE42968 (PubMed:16141072).Curated1
Sequence conflicti69G → D in BAE42968 (PubMed:16141072).Curated1
Sequence conflicti108H → Y in BAE42968 (PubMed:16141072).Curated1
Sequence conflicti291 – 293PPP → LPA in AAL58112 (PubMed:11891275).Curated3
Sequence conflicti321I → M in BAE42968 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01761027A → AA in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329487 mRNA Translation: AAL23897.1
AF426462 mRNA Translation: AAL58112.1
AF531424 mRNA Translation: AAM97592.1
AK041572 mRNA Translation: BAC30990.1
AK172370 mRNA Translation: BAE42968.1
BC064708 mRNA Translation: AAH64708.1
CCDSiCCDS48439.1 [Q920A9-1]
CCDS48440.1 [Q920A9-2]
RefSeqiNP_001153687.1, NM_001160215.1 [Q920A9-2]
NP_660123.1, NM_145141.2 [Q920A9-1]
UniGeneiMm.1850

Genome annotation databases

EnsembliENSMUST00000046322; ENSMUSP00000036380; ENSMUSG00000038421 [Q920A9-2]
ENSMUST00000159171; ENSMUSP00000124853; ENSMUSG00000038421 [Q920A9-1]
GeneIDi98752
KEGGimmu:98752
UCSCiuc007dmq.2 mouse [Q920A9-1]
uc007dmr.2 mouse [Q920A9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329487 mRNA Translation: AAL23897.1
AF426462 mRNA Translation: AAL58112.1
AF531424 mRNA Translation: AAM97592.1
AK041572 mRNA Translation: BAC30990.1
AK172370 mRNA Translation: BAE42968.1
BC064708 mRNA Translation: AAH64708.1
CCDSiCCDS48439.1 [Q920A9-1]
CCDS48440.1 [Q920A9-2]
RefSeqiNP_001153687.1, NM_001160215.1 [Q920A9-2]
NP_660123.1, NM_145141.2 [Q920A9-1]
UniGeneiMm.1850

3D structure databases

ProteinModelPortaliQ920A9
SMRiQ920A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ920A9, 1 interactor
STRINGi10090.ENSMUSP00000036380

PTM databases

iPTMnetiQ920A9
PhosphoSitePlusiQ920A9

Proteomic databases

EPDiQ920A9
PaxDbiQ920A9
PRIDEiQ920A9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046322; ENSMUSP00000036380; ENSMUSG00000038421 [Q920A9-2]
ENSMUST00000159171; ENSMUSP00000124853; ENSMUSG00000038421 [Q920A9-1]
GeneIDi98752
KEGGimmu:98752
UCSCiuc007dmq.2 mouse [Q920A9-1]
uc007dmr.2 mouse [Q920A9-2]

Organism-specific databases

CTDi84824
MGIiMGI:2138647 Fcrla

Phylogenomic databases

eggNOGiENOG410IHSR Eukaryota
ENOG4111EGY LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG059243
InParanoidiQ920A9
OMAiPPGPNKE
OrthoDBiEOG091G0ETN
PhylomeDBiQ920A9
TreeFamiTF335097

Miscellaneous databases

PROiPR:Q920A9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038421 Expressed in 78 organ(s), highest expression level in bone marrow
CleanExiMM_FCRL1
MM_FCRLA
ExpressionAtlasiQ920A9 baseline and differential
GenevisibleiQ920A9 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRLA_MOUSE
AccessioniPrimary (citable) accession number: Q920A9
Secondary accession number(s): Q3T9Q2, Q8K3U9, Q8VHP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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