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Protein

Opticin

Gene

Optc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds collagen fibrils.By similarity

GO - Biological processi

  • negative regulation of angiogenesis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Opticin
Alternative name(s):
Oculoglycan
Gene namesi
Name:Optc
Synonyms:Opt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2151113 Optc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003276620 – 328OpticinAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei69SulfotyrosineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 318By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

MaxQBiQ920A0
PaxDbiQ920A0
PRIDEiQ920A0

PTM databases

PhosphoSitePlusiQ920A0

Expressioni

Tissue specificityi

Present in the presumptive ciliary body during development and in the nonpigmented ciliary epithelium of the adult eye.

Gene expression databases

CleanExiMM_OPTC

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120568

Structurei

3D structure databases

ProteinModelPortaliQ920A0
SMRiQ920A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 149LRRNTAdd BLAST38
Repeati150 – 171LRR 1Add BLAST22
Repeati174 – 195LRR 2Add BLAST22
Repeati198 – 219LRR 3Add BLAST22
Repeati244 – 265LRR 4Add BLAST22
Repeati266 – 286LRR 5Add BLAST21
Repeati296 – 316LRR 6Add BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 110Ser/Thr-richAdd BLAST32
Compositional biasi124 – 136Cys-richAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000273909
HOVERGENiHBG006850
InParanoidiQ920A0
KOiK08128
PhylomeDBiQ920A0

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q920A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLAFLSLL SLVLQKAETA SLLGEREREE QSPEEGDTYA SLYVGNHTLS
60 70 80 90 100
IEDYNEVIDL SNYEELADYG DQIPEAKISN LTLPTRTSPT STVAQKTLSP
110 120 130 140 150
NLTMAVPTTT GLLNSQSSHG LPTCLVCVCL GSSVYCDDAD LENIPPLPQM
160 170 180 190 200
TTYLYARFNH ISHIQAGDFK GLTKLRRIDL SGNSISSIHN DALRLLPALQ
210 220 230 240 250
DLILPENQLA ALPVLPSGIE FLDVRLNRLQ SSGIQPEAFV ALKKLQFLYL
260 270 280 290 300
ANNMLDSIPG PLPLSLRSLH LQNNMIETME SDTFCDTGEH RHERRQLEDI
310 320
RLDGNPINLS LFPEAYFCLP RLPVGHFT
Length:328
Mass (Da):36,422
Last modified:July 27, 2011 - v2
Checksum:i3DF84F66FFC66DF3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVW2G3UVW2_MOUSE
Opticin
Optc mCG_6928
381Annotation score:
E9PUR1E9PUR1_MOUSE
Opticin
Optc
328Annotation score:
F6Z4X6F6Z4X6_MOUSE
Opticin
Optc
300Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168D → Y in AAL12836 (PubMed:11527931).Curated1
Sequence conflicti168D → Y in AAL12835 (PubMed:11527931).Curated1
Sequence conflicti285 – 287CDT → SLS in AAL12836 (PubMed:11527931).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333980 mRNA Translation: AAL12835.1
AF333981 Genomic DNA Translation: AAL12836.1
AY077682 mRNA Translation: AAL78287.1
RefSeqiNP_473417.2, NM_054076.3
UniGeneiMm.59985

Genome annotation databases

GeneIDi269120
KEGGimmu:269120

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333980 mRNA Translation: AAL12835.1
AF333981 Genomic DNA Translation: AAL12836.1
AY077682 mRNA Translation: AAL78287.1
RefSeqiNP_473417.2, NM_054076.3
UniGeneiMm.59985

3D structure databases

ProteinModelPortaliQ920A0
SMRiQ920A0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120568

PTM databases

PhosphoSitePlusiQ920A0

Proteomic databases

MaxQBiQ920A0
PaxDbiQ920A0
PRIDEiQ920A0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi269120
KEGGimmu:269120

Organism-specific databases

CTDi26254
MGIiMGI:2151113 Optc

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000273909
HOVERGENiHBG006850
InParanoidiQ920A0
KOiK08128
PhylomeDBiQ920A0

Miscellaneous databases

ChiTaRSiItpr1 mouse
PROiPR:Q920A0
SOURCEiSearch...

Gene expression databases

CleanExiMM_OPTC

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOPT_MOUSE
AccessioniPrimary (citable) accession number: Q920A0
Secondary accession number(s): Q8K3K2, Q91ZZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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