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Protein

Cytochrome P450 2K1

Gene

cyp2k1

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi447Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • aflatoxin B1 metabolic process Source: AgBase
  • lauric acid metabolic process Source: AgBase
  • lipid hydroxylation Source: AgBase

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2K1 (EC:1.14.14.1)
Alternative name(s):
CYPIIK1
Cytochrome P450 LMC2
Gene namesi
Name:cyp2k1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517731 – 504Cytochrome P450 2K1Add BLAST504

Proteomic databases

PRIDEiQ92090

Expressioni

Inductioni

Constitutively expressed.

Structurei

3D structure databases

ProteinModelPortaliQ92090
SMRiQ92090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q92090-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLIEDILQT SSTVTLLGTV LFLLVLYLRS SGSSSEEQGK EPPGPRPLPL
60 70 80 90 100
LGNMLQLDLK KPYCTLCELS KKYGSIFTVH FGPKKVVVLA GYKTVKQALV
110 120 130 140 150
NQAEDFGDRD ITPVFYDFNQ GHGILFANGD SWKEMRRFAL TNLRDFGMGK
160 170 180 190 200
KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ SVLYAVSNII SAIVYGSRFE
210 220 230 240 250
YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN LTRLKKNIAD
260 270 280 290 300
MKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL
310 320 330 340 350
VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SRVIGSRQTL
360 370 380 390 400
VEDRKNLPYT DAVIHETQRL ANIVPMSVPH TTSRDVTFQG YFIKKGTSVI
410 420 430 440 450
PLLTSVLQDD SEWESPNTFN PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE
460 470 480 490 500
GLARMELFLF FTSLLQRFRF SPPPGVTEDD LDLTPLLGFT LNPSPHQLCA

VSRV
Length:504
Mass (Da):56,792
Last modified:November 1, 1996 - v1
Checksum:i3EFAE8D78D5EB21F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6 – 7DI → GL in allele CYP2K1v2. 2
Natural varianti37E → G in allele CYP2K1v2. 1
Natural varianti79V → F in allele CYP2K1v2. 1
Natural varianti256I → T in allele CYP2K1v2. 1
Natural varianti261G → S in allele CYP2K1v2. 1
Natural varianti372N → D in allele CYP2K1v2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11528 mRNA Translation: AAA52078.1
AF045052 mRNA Translation: AAC28309.1
PIRiS45644
UniGeneiOmy.30070

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11528 mRNA Translation: AAA52078.1
AF045052 mRNA Translation: AAC28309.1
PIRiS45644
UniGeneiOmy.30070

3D structure databases

ProteinModelPortaliQ92090
SMRiQ92090
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92090

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG015789

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2K1_ONCMY
AccessioniPrimary (citable) accession number: Q92090
Secondary accession number(s): O93304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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