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UniProtKB - Q92085 (PA2NB_NAJSP)
Protein
Neutral phospholipase A2 B
Gene
N/A
Organism
Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)
Status
Functioni
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
By similarityCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+PROSITE-ProRule annotationEC:3.1.1.4PROSITE-ProRule annotation
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 54 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 56 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 58 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 74 | By similarity | 1 | |
Metal bindingi | 75 | CalciumBy similarity | 1 | |
Active sitei | 120 | By similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: UniProtKB-KW
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Toxin |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Neutral phospholipase A2 B (EC:3.1.1.4)Short name: svPLA2 Alternative name(s): NAJPLA-2B Short name: NPLA Phosphatidylcholine 2-acylhydrolase |
Organismi | Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix) |
Taxonomic identifieri | 33626 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Elapinae › Naja |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000022932 | 22 – 27 | By similarity | 6 | |
ChainiPRO_0000022933 | 28 – 146 | Neutral phospholipase A2 BAdd BLAST | 119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 98 | By similarity | ||
Disulfide bondi | 53 ↔ 145 | By similarity | ||
Disulfide bondi | 55 ↔ 71 | By similarity | ||
Disulfide bondi | 70 ↔ 126 | By similarity | ||
Disulfide bondi | 77 ↔ 119 | By similarity | ||
Disulfide bondi | 87 ↔ 112 | By similarity | ||
Disulfide bondi | 105 ↔ 117 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q92085-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPAHLLILA AVCVSPLGAS SNRPMPLNLY QFKNMVQCTV PNRSWWHFAD
60 70 80 90 100
YGCYCGRGGS GTPVDDLDRC CQIHDNCYNE AEKISRCWPY FKTYSYECSQ
110 120 130 140
GTLTCKGGNN ACAAAVCDCD RLAAICFAGA PYNDNNYNID LKARCQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42005 mRNA Translation: AAA66028.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L42005 mRNA Translation: AAA66028.1 |
3D structure databases
SMRi | Q92085 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2NB_NAJSP | |
Accessioni | Q92085Primary (citable) accession number: Q92085 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |