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Protein

Acetylserotonin O-methyltransferase

Gene

ASMT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).By similarity

Catalytic activityi

S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.

Pathwayi: melatonin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes melatonin from serotonin.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serotonin N-acetyltransferase (AANAT), Acetylserotonin O-methyltransferase (ASMT)
  2. no protein annotated in this organism
This subpathway is part of the pathway melatonin biosynthesis, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes melatonin from serotonin, the pathway melatonin biosynthesis and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei148S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei165S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei211S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei253S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei256Proton donor/acceptorBy similarity1
Binding sitei257SubstrateBy similarity1
Binding sitei303SubstrateBy similarity1
Binding sitei307SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processMelatonin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayi
UPA00837;UER00815

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylserotonin O-methyltransferase (EC:2.1.1.4)
Alternative name(s):
Hydroxyindole O-methyltransferase
Short name:
HIOMT
Gene namesi
Name:ASMT
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839811 – 346Acetylserotonin O-methyltransferaseAdd BLAST346

Proteomic databases

PaxDbiQ92056

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026872

Structurei

3D structure databases

ProteinModelPortaliQ92056
SMRiQ92056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 238S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3178 Eukaryota
ENOG410XS7T LUCA
HOGENOMiHOG000247024
HOVERGENiHBG001526
InParanoidiQ92056
KOiK00543
PhylomeDBiQ92056

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR031725 ASMT_dimerisation
IPR016461 O-MeTrfase_COMT
IPR001077 O_MeTrfase_2
IPR029063 SAM-dependent_MTases
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF16864 Dimerisation2, 1 hit
PF00891 Methyltransf_2, 1 hit
PIRSFiPIRSF005739 O-mtase, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51683 SAM_OMT_II, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q92056-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTEDLDYP QIIFQYSNGF LVSKVMFTAC ELGVFDLLLQ SGRPLSLDVI
60 70 80 90 100
AARLGTSIMG MERLLDACVG LKLLAVELRR EGAFYRNTEI SNIYLTKSSP
110 120 130 140 150
KSQYHIMMYY SNTVYLCWHY LTDAVREGRN QYERAFGISS KDLFGARYRS
160 170 180 190 200
EEEMLKFLAG QNSIWSICGR DVLTAFDLSP FTQIYDLGGG GGALAQECVF
210 220 230 240 250
LYPNCTVTIY DLPKVVQVAK ERLVPPEERR IAFHEGDFFK DSIPEADLYI
260 270 280 290 300
LSKILHDWDD KKCRQLLAEV YKACRPGGGV LLVESLLSED RSGPVETQLY
310 320 330 340
SLNMLVQTEG KERTAVEYSE LLGAAGFREV QVRRTGKLYD AVLGRK
Length:346
Mass (Da):39,136
Last modified:November 1, 1997 - v1
Checksum:i3EB370E4488CC5E8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1NFG5F1NFG5_CHICK
Acetylserotonin O-methyltransferase
ASMT
346Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62309 mRNA Translation: CAA44189.1
PIRiS21265
RefSeqiNP_990674.1, NM_205343.1
UniGeneiGga.1821

Genome annotation databases

GeneIDi396286
KEGGigga:396286

Similar proteinsi

Entry informationi

Entry nameiASMT_CHICK
AccessioniPrimary (citable) accession number: Q92056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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