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Protein

Gap junction gamma-1 protein

Gene

gjc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Participates in a developmental pathway for formation of the notochord and tail.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-43.4
Short name:
Cx43.4
Gap junction alpha-7 protein
Gene namesi
Name:gjc1
Synonyms:cx43.4, gja7
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-38 cx43.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 171CytoplasmicSequence analysisAdd BLAST76
Transmembranei172 – 194HelicalSequence analysisAdd BLAST23
Topological domaini195 – 228ExtracellularSequence analysisAdd BLAST34
Transmembranei229 – 251HelicalSequence analysisAdd BLAST23
Topological domaini252 – 380CytoplasmicSequence analysisAdd BLAST129

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578291 – 380Gap junction gamma-1 proteinAdd BLAST380

Proteomic databases

PaxDbiQ92052

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015225

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiQ92052
PhylomeDBiQ92052

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q92052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWSFLTRLL DEISNHSTFV GKIWLTLFII FRIVLTVVGG ESIYYDEQSK
60 70 80 90 100
FVCNTQQPGC ENVCYDAFAP LSHVRFWVFQ IILITTPTIM YLGFAMHKIA
110 120 130 140 150
RSNDVEYRPV NRKRMPMINR GRNRDYEEAE DNGEEDPMIM EEIVPEKEKA
160 170 180 190 200
PEKSAVKHDG RRRIKRDGLM KVYILQLLSR IIFEVGFLFG QYILYGFEVA
210 220 230 240 250
PSYVCTRSPC PHTVDCFVSR PTEKTIFLLI MYAVSCLCLS LTVLEILHLG
260 270 280 290 300
LSGIRDAFRR RARHQSVQRP RAPICRQVPT APPGYHTALK KDKLSLGMKP
310 320 330 340 350
EYNLDSGRES FGDESSSRDI DRLRRHLKLA QQHLDLAYQN GESSPSRSSS
360 370 380
PESNGTAVEQ NRLNFAQEKQ GSKCEKGIHA
Length:380
Mass (Da):43,578
Last modified:November 1, 1996 - v1
Checksum:i7560894FC06C6C90
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0UYC0B0UYC0_DANRE
Gap junction protein
cx43.4
380Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122R → A in AAB36619 (PubMed:8806823).Curated1
Sequence conflicti207R → P in AAB36619 (PubMed:8806823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96712 mRNA Translation: CAA65473.1
L46801 mRNA Translation: AAB36619.1
UniGeneiDr.18287

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96712 mRNA Translation: CAA65473.1
L46801 mRNA Translation: AAB36619.1
UniGeneiDr.18287

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000015225

Proteomic databases

PaxDbiQ92052

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990415-38 cx43.4

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiQ92052
PhylomeDBiQ92052

Miscellaneous databases

PROiPR:Q92052

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXG1_DANRE
AccessioniPrimary (citable) accession number: Q92052
Secondary accession number(s): Q92053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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