Protein Wnt-5b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ZFIN <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• ameboidal-type cell migration Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Wnt5 signaling in vertebrate pancreas development."
    Kim H.J., Schleiffarth J.R., Jessurun J., Sumanas S., Petryk A., Lin S., Ekker S.C.
    BMC Biol 3:23-23(2005) [PubMed] [Europe PMC] [Abstract]
• angiogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "A role for planar cell polarity signaling in angiogenesis."
    Cirone P., Lin S., Griesbach H.L., Zhang Y., Slusarski D.C., Crews C.M.
    Angiogenesis 11:347-360(2008) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cartilage morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "A role of glypican4 and wnt5b in chondrocyte stacking underlying craniofacial cartilage morphogenesis."
    Sisson B.E., Dale R.M., Mui S.R., Topczewska J.M., Topczewski J.
    Mech Dev 138:279-290(2015) [PubMed] [Europe PMC] [Abstract]
  • "Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification."
    Ling I.T., Rochard L., Liao E.C.
    Dev Biol 421:219-232(2017) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell migration involved in gastrulation Source: ZFINInferred from mutant phenotypeⁱ
  • "RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling."
    Zhu S., Liu L., Korzh V., Gong Z., Low B.C.
    Cell Signal 18:359-372(2006) [PubMed] [Europe PMC] [Abstract]
• chondrocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation."
    Piotrowski T., Schilling T.F., Brand M., Jiang Y.J., Heisenberg C.P., Beuchle D., Grandel H., van Eeden F.J., Furutani-Seiki M., Granato M., Haffter P., Hammerschmidt M., Kane D.A., Kelsh R.N., Mullins M.C., Odenthal J., Warga R.M., Nusslein-Volhard C.
    Development 123:345-356(1996) [PubMed] [Europe PMC] [Abstract]
• convergent extension Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response."
    Gerdes J.M., Liu Y., Zaghloul N.A., Leitch C.C., Lawson S.S., Kato M., Beachy P.A., Beales P.L., DeMartino G.N., Fisher S., Badano J.L., Katsanis N.
    Nat Genet 39:1350-1360(2007) [PubMed] [Europe PMC] [Abstract]
• convergent extension involved in axis elongation Source: ZFINInferred from mutant phenotypeⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]
• convergent extension involved in gastrulation Source: ZFINInferred from mutant phenotypeⁱ
  • "The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation."
    Kilian B., Mansukoski H., Barbosa F.C., Ulrich F., Tada M., Heisenberg C.P.
    Mech Dev 120:467-476(2003) [PubMed] [Europe PMC] [Abstract]
  • "Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements."
    Jopling C., den Hertog J.
    EMBO Rep. 6:426-431(2005) [PubMed] [Europe PMC] [Abstract]
  • "Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects."
    Jopling C., van Geemen D., den Hertog J.
    PLoS Genet 3:e225-e225(2007) [PubMed] [Europe PMC] [Abstract]
• dorsal convergence Source: ZFINInferred from mutant phenotypeⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]
• embryonic body morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Wnt5 is required for tail formation in the zebrafish embryo."
    Rauch G.J., Hammerschmidt M., Blader P., Schauerte H.E., Strahle U., Ingham P.W., McMahon A.P., Haffter P.
    Cold Spring Harb Symp Quant Biol 62:227-234(1997) [PubMed] [Europe PMC] [Abstract]
• embryonic cranial skeleton morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio."
    Hammerschmidt M., Pelegri F., Mullins M.C., Kane D.A., Brand M., van Eeden F.J.M., Furutani-Seiki M., Granato M., Haffter P., Heisenberg C.-P., Jiang Y.-J., Kelsh R.N., Odenthal J., Warga R.M., Nuesslein-Volhard C.
    Development 123:143-151(1996) [PubMed] [Europe PMC] [Abstract]
• embryonic viscerocranium morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression."
    Wu B.T., Wen S.H., Hwang S.P., Huang C.J., Kuan Y.S.
    J Cell Sci 128:2328-2339(2015) [PubMed] [Europe PMC] [Abstract]
• endochondral ossification Source: ZFINInferred from mutant phenotypeⁱ
  • "Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification."
    Ling I.T., Rochard L., Liao E.C.
    Dev Biol 421:219-232(2017) [PubMed] [Europe PMC] [Abstract]
• endocrine pancreas development Source: ZFINInferred from mutant phenotypeⁱ
  • "Wnt5 signaling in vertebrate pancreas development."
    Kim H.J., Schleiffarth J.R., Jessurun J., Sumanas S., Petryk A., Lin S., Ekker S.C.
    BMC Biol 3:23-23(2005) [PubMed] [Europe PMC] [Abstract]
• fin regeneration Source: ZFINInferred from mutant phenotypeⁱ
  • "Distinct Wnt signaling pathways have opposing roles in appendage regeneration."
    Stoick-Cooper C.L., Weidinger G., Riehle K.J., Hubbert C., Major M.B., Fausto N., Moon R.T.
    Development 134:479-489(2007) [PubMed] [Europe PMC] [Abstract]
  • "Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins."
    Lee Y., Hami D., De Val S., Kagermeier-Schenk B., Wills A.A., Black B.L., Weidinger G., Poss K.D.
    Dev Biol 331:270-280(2009) [PubMed] [Europe PMC] [Abstract]
• lymphangiogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Lymphatic vessels arise from specialized angioblasts within a venous niche."
    Nicenboim J., Malkinson G., Lupo T., Asaf L., Sela Y., Mayseless O., Gibbs-Bar L., Senderovich N., Hashimshony T., Shin M., Jerafi-Vider A., Avraham-Davidi I., Krupalnik V., Hofi R., Almog G., Astin J.W., Golani O., Ben-Dor S.

    , Crosier P.S., Herzog W., Lawson N.D., Hanna J.H., Yanai I., Yaniv K.
    Nature 522:56-61(2015) [PubMed] [Europe PMC] [Abstract]
• midbrain-hindbrain boundary morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase."
    Gutzman J.H., Graeden E., Brachmann I., Yamazoe S., Chen J.K., Sive H.
    Biol Open 7:0-0(2018) [PubMed] [Europe PMC] [Abstract]
• muscle cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.3

    "Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish."
    Lou Q., He J., Hu L., Yin Z.
    Biochim. Biophys. Acta 1823:1024-1032(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• neuromast development Source: ZFINInferred from mutant phenotypeⁱ
  • "Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system."
    Louwette S., Labarque V., Wittevrongel C., Thys C., Metz J., Gijsbers R., Debyser Z., Arnout J., Van Geet C., Freson K.
    FASEB J 26:2125-2136(2012) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• ossification Source: ZFINInferred from mutant phenotypeⁱ
  • "Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification."
    Ling I.T., Rochard L., Liao E.C.
    Dev Biol 421:219-232(2017) [PubMed] [Europe PMC] [Abstract]
• otolith development Source: ZFINInferred from mutant phenotypeⁱ
  • "Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system."
    Louwette S., Labarque V., Wittevrongel C., Thys C., Metz J., Gijsbers R., Debyser Z., Arnout J., Van Geet C., Freson K.
    FASEB J 26:2125-2136(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of convergent extension involved in gastrulation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.3

    "Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish."
    Lou Q., He J., Hu L., Yin Z.
    Biochim. Biophys. Acta 1823:1024-1032(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• positive regulation of non-canonical Wnt signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.3

    "Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish."
    Lou Q., He J., Hu L., Yin Z.
    Biochim. Biophys. Acta 1823:1024-1032(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• post-anal tail morphogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio."
    Hammerschmidt M., Pelegri F., Mullins M.C., Kane D.A., Brand M., van Eeden F.J.M., Furutani-Seiki M., Granato M., Haffter P., Heisenberg C.-P., Jiang Y.-J., Kelsh R.N., Odenthal J., Warga R.M., Nuesslein-Volhard C.
    Development 123:143-151(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of Wnt signaling pathway, calcium modulating pathway Source: ZFINInferred from mutant phenotypeⁱ
  • "Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning."
    Freisinger C.M., Fisher R.A., Slusarski D.C.
    PLoS Genet 6:e1001020-e1001020(2010) [PubMed] [Europe PMC] [Abstract]
• release of sequestered calcium ion into cytosol Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: ZFINInferred from mutant phenotypeⁱ
  • "Wnt5 is required for tail formation in the zebrafish embryo."
    Rauch G.J., Hammerschmidt M., Blader P., Schauerte H.E., Strahle U., Ingham P.W., McMahon A.P., Haffter P.
    Cold Spring Harb Symp Quant Biol 62:227-234(1997) [PubMed] [Europe PMC] [Abstract]
• somite development Source: ZFINInferred from genetic interactionⁱ
  • "Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning."
    Freisinger C.M., Fisher R.A., Slusarski D.C.
    PLoS Genet 6:e1001020-e1001020(2010) [PubMed] [Europe PMC] [Abstract]
• thrombocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system."
    Louwette S., Labarque V., Wittevrongel C., Thys C., Metz J., Gijsbers R., Debyser Z., Arnout J., Van Geet C., Freson K.
    FASEB J 26:2125-2136(2012) [PubMed] [Europe PMC] [Abstract]
• unidimensional cell growth Source: ZFINInferred from mutant phenotypeⁱ
  • "The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation."
    Kilian B., Mansukoski H., Barbosa F.C., Ulrich F., Tada M., Heisenberg C.P.
    Mech Dev 120:467-476(2003) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway, calcium modulating pathway Source: ZFINInferred from direct assayⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cytokine activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ZFINInferred from physical interactionⁱ
  • "Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement."
    Lin S., Baye L.M., Westfall T.A., Slusarski D.C.
    J Cell Biol 190:263-278(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MDVRMNQGHL LLAVTLIVCN SQLLVVANSW WSLAMNPIQR PEMYIIGAQP 
        60         70         80         90        100
LCSQLTGLSQ GQRKLCQLYQ DHMVYIGEGA KTGIKECQYQ FRQRRWNCST 
       110        120        130        140        150
VDNTSVFGRV MHIGSRETAF TYAVSAAGVV NAVSRACREG ELSTCGCSRA 
       160        170        180        190        200
ARPRDLPRDW LWGGCGDNVN YGYRFAREFV DAREREKNYP RGSVEHARTL 
       210        220        230        240        250
MNLQNNEAGR MAVYNLANVA CKCHGVSGSC SLKTCWLQLA DFRRVGEFLK 
       260        270        280        290        300
EKYDSAAAMR INRRGKLELV NNRFNPPTGE DLVYIDPSPD YCLRNETTGS 
       310        320        330        340        350
LGTQGRLCNK TSEGMDGCEL MCCGRGYDQF KTYKHERCHC KFHWCCYVKC 
       360 
KRCTSLVDQF VCK                                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families