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UniProtKB - Q91ZZ5 (RXFP2_MOUSE)
Protein
Relaxin receptor 2
Gene
Rxfp2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).
By similarityCaution
By homology with the human sequence, it is uncertain whether Met-1 is the initiator.Curated
GO - Molecular functioni
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: MGI
- protein-hormone receptor activity Source: MGI
GO - Biological processi
- activation of adenylate cyclase activity Source: GO_Central
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- hormone-mediated signaling pathway Source: GO_Central
- male gonad development Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell population proliferation Source: MGI
- oocyte maturation Source: MGI
- positive regulation of cAMP-mediated signaling Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-444821, Relaxin receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Relaxin receptor 2Alternative name(s): G-protein coupled receptor 106 G-protein coupled receptor affecting testicular descent Leucine-rich repeat-containing G-protein coupled receptor 8 Relaxin family peptide receptor 2 |
Gene namesi | Name:Rxfp2 Synonyms:Gpr106, Great, Lgr8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2153463, Rxfp2 |
VEuPathDBi | HostDB:ENSMUSG00000053368 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 399 | ExtracellularSequence analysisAdd BLAST | 399 | |
Transmembranei | 400 – 420 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 421 – 438 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 439 – 459 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 460 – 478 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 479 – 501 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 502 – 520 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 521 – 541 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 542 – 575 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 576 – 596 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 597 – 622 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 623 – 643 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 644 – 653 | ExtracellularSequence analysis | 10 | |
Transmembranei | 654 – 674 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 675 – 737 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Defects in Rxfp2 seems to be a cause of impaired testicular descent (known as cryptorchidism).1 Publication
Chemistry databases
ChEMBLi | CHEMBL3714702 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069703 | 1 – 737 | Relaxin receptor 2Add BLAST | 737 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 41 | By similarity | ||
Disulfide bondi | 35 ↔ 54 | By similarity | ||
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 48 ↔ 63 | By similarity | ||
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 257 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 361 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 478 ↔ 556 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q91ZZ5 |
PRIDEi | Q91ZZ5 |
ProteomicsDBi | 256552 |
PTM databases
GlyGeni | Q91ZZ5, 6 sites |
iPTMneti | Q91ZZ5 |
PhosphoSitePlusi | Q91ZZ5 |
Expressioni
Tissue specificityi
Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart.
Gene expression databases
Bgeei | ENSMUSG00000053368, Expressed in spermatocyte and 96 other tissues |
Genevisiblei | Q91ZZ5, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 228271, 1 interactor |
STRINGi | 10090.ENSMUSP00000067897 |
Miscellaneous databases
RNActi | Q91ZZ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 64 | LDL-receptor class APROSITE-ProRule annotationAdd BLAST | 38 | |
Repeati | 121 – 142 | LRR 1Add BLAST | 22 | |
Repeati | 145 – 166 | LRR 2Add BLAST | 22 | |
Repeati | 169 – 190 | LRR 3Add BLAST | 22 | |
Repeati | 193 – 214 | LRR 4Add BLAST | 22 | |
Repeati | 217 – 238 | LRR 5Add BLAST | 22 | |
Repeati | 241 – 262 | LRR 6Add BLAST | 22 | |
Repeati | 265 – 286 | LRR 7Add BLAST | 22 | |
Repeati | 289 – 310 | LRR 8Add BLAST | 22 | |
Repeati | 313 – 334 | LRR 9Add BLAST | 22 | |
Repeati | 337 – 358 | LRR 10Add BLAST | 22 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG2087, Eukaryota |
GeneTreei | ENSGT00940000158948 |
InParanoidi | Q91ZZ5 |
OMAi | DNIGWAD |
OrthoDBi | 559381at2759 |
PhylomeDBi | Q91ZZ5 |
TreeFami | TF326185 |
Family and domain databases
CDDi | cd00112, LDLa, 1 hit |
Gene3Di | 3.80.10.10, 2 hits 4.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR008112, Relaxin_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF00057, Ldl_recept_a, 1 hit PF13855, LRR_8, 2 hits |
PRINTSi | PR00237, GPCRRHODOPSN PR01739, RELAXINR |
SMARTi | View protein in SMART SM00192, LDLa, 1 hit SM00369, LRR_TYP, 10 hits |
SUPFAMi | SSF57424, SSF57424, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit PS51450, LRR, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q91ZZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLLLHVILL TEVKDFALAD SSMVAPLCPK GYFPCGNLTK CLPRAFHCDG
60 70 80 90 100
VDDCGNGADE DNCGDTSGWT TIFGTVHGNV NKVTLTQECF LSQYPQHCYC
110 120 130 140 150
RENELECVKA DLKAVPKVSS NVTLLSLKKN KIHRLPVKVF SRYTELRKIY
160 170 180 190 200
LQHNCITHIS RRAFLGLHNL QILYLSHNCI TSLRPGIFKD LHQLAWLILD
210 220 230 240 250
DNPITRISQK SFMGLNSLFF LSMVGNRLEA LPETLCAQMP QLNWVDLANN
260 270 280 290 300
GIKYITNSTF LTCDSLTVLF LPRNQIGFVP EKTFSSLKNL GELDLSSNMI
310 320 330 340 350
TKLPVHLFSD LHLLQKLNLS SNPLLYVHKN QFGSLKQLQS LDLERIEIPN
360 370 380 390 400
ISTGMFQPMK NLSHIYLKTF RYCSYVPHVR ICMPSTDGIS SSEDLLANGI
410 420 430 440 450
LRVSVWVIAF ITCVGNFLVI AVRSLIKAEN TTHAMSIKIL CCADCLMGVY
460 470 480 490 500
LFSVGVFDIK YRGQYQKYAL LWMESVPCRL LGFLATLSTE VSVLLLTFLT
510 520 530 540 550
LEKFLVIVFP FSNLRLGKRQ TAVALASIWV VGFLIAAVPF TREDYFGNFY
560 570 580 590 600
GKNGVCFPLH YDQAEDFGSR GYSLGIFLGV NLLAFLVIVI SYVTMFCSIH
610 620 630 640 650
KTALQTAEVR SHIGKEVAVA NRFFFIVFSD AICWIPVFVV KILSLLQVEI
660 670 680 690 700
PGTITSWIVV FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKPIFKV
710 720 730
KKKSLSASIV WTDESSLKLG VLSKIALGDS IMKPVSP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q0U9 | E9Q0U9_MOUSE | Relaxin receptor 2 | Rxfp2 | 713 | Annotation score: | ||
A0A0J9YV81 | A0A0J9YV81_MOUSE | Relaxin receptor 2 | Rxfp2 | 727 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 222 | S → P in AAL08943 (PubMed:11353515).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF346501 mRNA Translation: AAL08943.1 AC077689 Genomic DNA No translation available. BC120741 mRNA Translation: AAI20742.1 |
CCDSi | CCDS19886.1 |
RefSeqi | NP_001276493.1, NM_001289564.1 NP_001276495.1, NM_001289566.1 NP_536716.2, NM_080468.2 |
Genome annotation databases
Ensembli | ENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368 |
GeneIDi | 140498 |
KEGGi | mmu:140498 |
UCSCi | uc009ato.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF346501 mRNA Translation: AAL08943.1 AC077689 Genomic DNA No translation available. BC120741 mRNA Translation: AAI20742.1 |
CCDSi | CCDS19886.1 |
RefSeqi | NP_001276493.1, NM_001289564.1 NP_001276495.1, NM_001289566.1 NP_536716.2, NM_080468.2 |
3D structure databases
AlphaFoldDBi | Q91ZZ5 |
SMRi | Q91ZZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228271, 1 interactor |
STRINGi | 10090.ENSMUSP00000067897 |
Chemistry databases
ChEMBLi | CHEMBL3714702 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q91ZZ5, 6 sites |
iPTMneti | Q91ZZ5 |
PhosphoSitePlusi | Q91ZZ5 |
Proteomic databases
PaxDbi | Q91ZZ5 |
PRIDEi | Q91ZZ5 |
ProteomicsDBi | 256552 |
Protocols and materials databases
Antibodypediai | 22835, 324 antibodies from 29 providers |
Genome annotation databases
Ensembli | ENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368 |
GeneIDi | 140498 |
KEGGi | mmu:140498 |
UCSCi | uc009ato.1, mouse |
Organism-specific databases
CTDi | 122042 |
MGIi | MGI:2153463, Rxfp2 |
VEuPathDBi | HostDB:ENSMUSG00000053368 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota KOG2087, Eukaryota |
GeneTreei | ENSGT00940000158948 |
InParanoidi | Q91ZZ5 |
OMAi | DNIGWAD |
OrthoDBi | 559381at2759 |
PhylomeDBi | Q91ZZ5 |
TreeFami | TF326185 |
Enzyme and pathway databases
Reactomei | R-MMU-418555, G alpha (s) signalling events R-MMU-444821, Relaxin receptors |
Miscellaneous databases
BioGRID-ORCSi | 140498, 4 hits in 72 CRISPR screens |
ChiTaRSi | Rxfp2, mouse |
PROi | PR:Q91ZZ5 |
RNActi | Q91ZZ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053368, Expressed in spermatocyte and 96 other tissues |
Genevisiblei | Q91ZZ5, MM |
Family and domain databases
CDDi | cd00112, LDLa, 1 hit |
Gene3Di | 3.80.10.10, 2 hits 4.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR002172, LDrepeatLR_classA_rpt IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR008112, Relaxin_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF00057, Ldl_recept_a, 1 hit PF13855, LRR_8, 2 hits |
PRINTSi | PR00237, GPCRRHODOPSN PR01739, RELAXINR |
SMARTi | View protein in SMART SM00192, LDLa, 1 hit SM00369, LRR_TYP, 10 hits |
SUPFAMi | SSF57424, SSF57424, 1 hit |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit PS51450, LRR, 10 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RXFP2_MOUSE | |
Accessioni | Q91ZZ5Primary (citable) accession number: Q91ZZ5 Secondary accession number(s): Q0VB90 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families